Search Results - "NAKAKI, Toshio"

Glutathione in Cellular Redox Homeostasis: Association with the Excitatory Amino Acid Carrier 1 (EAAC1) by Aoyama, Koji, Nakaki, Toshio

“…Reactive oxygen species (ROS) are by-products of the cellular metabolism of oxygen consumption, produced mainly in the mitochondria. ROS are known to be highly…”
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Impaired glutathione synthesis in neurodegeneration by Aoyama, Koji, Nakaki, Toshio

“…Glutathione (GSH) was discovered in yeast cells in 1888. Studies of GSH in mammalian cells before the 1980s focused exclusively on its function for the…”
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Regulation of Neuronal Glutathione Synthesis by Aoyama, Koji, Watabe, Masahiko, Nakaki, Toshio

“…The brain is among the major organs generating large amounts of reactive oxygen species and is especially susceptible to oxidative stress. Glutathione (GSH)…”
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Protein kinase CK2 regulates the formation and clearance of aggresomes in response to stress by Watabe, Masahiko, Nakaki, Toshio

“…Misfolded protein aggregates elicit a stress response, and their clearance is crucial for cell survival. These aggregates are transported by cytoplasmic…”
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Neuroprotection afforded by circadian regulation of intracellular glutathione levels: A key role for miRNAs by Kinoshita, Chisato, Aoyama, Koji, Nakaki, Toshio

“…Circadian rhythms are approximately 24-h oscillations of physiological and behavioral processes that allow us to adapt to daily environmental cycles. Like many…”
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A purine derivative, paraxanthine, promotes cysteine uptake for glutathione synthesis by Matsumura, Nobuko, Kinoshita, Chisato, Bhadhprasit, Wattanaporn, Nakaki, Toshio, Aoyama, Koji

“…Purine derivatives such as caffeine and uric acid have neuroprotective activities and are negatively correlated with the incidence of both Alzheimer's disease…”
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Neuroprotective properties of the excitatory amino acid carrier 1 (EAAC1) by Aoyama, Koji, Nakaki, Toshio

“…Extracellular glutamate should be maintained at low levels to conserve optimal neurotransmission and prevent glutamate neurotoxicity in the brain. Excitatory…”
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Rhythmic oscillations of the microRNA miR-96-5p play a neuroprotective role by indirectly regulating glutathione levels by Kinoshita, Chisato, Aoyama, Koji, Matsumura, Nobuko, Kikuchi-Utsumi, Kazue, Watabe, Masahiko, Nakaki, Toshio

“…Glutathione (GSH) is a key antioxidant that plays an important neuroprotective role in the brain. Decreased GSH levels are associated with neurodegenerative…”
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MicroRNA: A Key Player for the Interplay of Circadian Rhythm Abnormalities, Sleep Disorders and Neurodegenerative Diseases by Kinoshita, Chisato, Okamoto, Yayoi, Aoyama, Koji, Nakaki, Toshio

“…Circadian rhythms are endogenous 24-h oscillators that regulate the sleep/wake cycles and the timing of biological systems to optimize physiology and behavior…”
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A simple and effective method for detecting precipitated proteins in MALDI−TOF MS by Oshikane, Hiroyuki, Watabe, Masahiko, Nakaki, Toshio

“…MALDI−TOF MS has developed rapidly into an essential analytical tool for the life sciences. Cinnamic acid derivatives are generally employed in routine…”
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Inhibition of GTRAP3-18 may increase neuroprotective glutathione (GSH) synthesis by Aoyama, Koji, Nakaki, Toshio

“…Glutathione (GSH) is a tripeptide consisting of glutamate, cysteine, and glycine; it has a variety of functions in the central nervous system. Brain GSH…”
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Mitochondrial complex I inhibitor rotenone inhibits and redistributes vesicular monoamine transporter 2 via nitration in human dopaminergic SH-SY5Y cells by Watabe, Masahiko, Nakaki, Toshio

“…Parkinson's disease is a progressive neurodegenerative disorder characterized by selective degeneration of nigrostriatal dopaminergic neurons. Long-term…”
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Mitochondrial complex I inhibitor rotenone-elicited dopamine redistribution from vesicles to cytosol in human dopaminergic SH-SY5Y cells by Watabe, Masahiko, Nakaki, Toshio

“…Parkinson's disease is a chronic neurodegenerative disorder characterized by loss of dopaminergic neurons in the substantia nigra. Rotenone, a pesticide,…”
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Modulation of neuronal glutathione synthesis by EAAC1 and its interacting protein GTRAP3-18 by Aoyama, Koji, Watabe, Masahiko, Nakaki, Toshio

“…Glutathione (GSH) plays essential roles in different processes such as antioxidant defenses, cell signaling, cell proliferation, and apoptosis in the central…”
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GTRAP3‐18 regulates food intake and body weight by interacting with pro‐opiomelanocortin by Aoyama, Koji, Bhadhprasit, Wattanaporn, Watabe, Masahiko, Wang, Fan, Matsumura, Nobuko, Nakaki, Toshio

“…Pro‐opiomelanocortin (POMC)‐expressing neurons provide α‐melanocyte‐stimulating hormone (α‐MSH), which stimulates melanocortin 4 receptor to induce hypophagia…”
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Oxidative stress on EAAC1 is involved in MPTP-induced glutathione depletion and motor dysfunction by Aoyama, Koji, Matsumura, Nobuko, Watabe, Masahiko, Nakaki, Toshio

“…Excitatory amino acid carrier 1 (EAAC1) is a glutamate transporter expressed on mature neurons in the CNS, and is the primary route for uptake of the neuronal…”
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Inhibition of miR-96-5p in the mouse brain increases glutathione levels by altering NOVA1 expression by Kinoshita, Chisato, Kikuchi-Utsumi, Kazue, Aoyama, Koji, Suzuki, Ryo, Okamoto, Yayoi, Matsumura, Nobuko, Omata, Daiki, Maruyama, Kazuo, Nakaki, Toshio

“…Glutathione (GSH) is an important antioxidant that plays a critical role in neuroprotection. GSH depletion in neurons induces oxidative stress and thereby…”
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A Dominant Role of GTRAP3-18 in Neuronal Glutathione Synthesis by Watabe, Masahiko, Aoyama, Koji, Nakaki, Toshio

“…Glutathione is an essential reductant which protects cells and is reduced in neurodegenerative disorders such as Parkinson's and Alzheimer's diseases. Neurons…”
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Oral Flavonoid Supplementation Attenuates Atherosclerosis Development in Apolipoprotein E–Deficient Mice by Hishikawa, Keiichi, Nakaki, Toshio, Fujita, Toshiro

“…OBJECTIVE—Caffeic acid phenethyl ester (CAPE), a natural flavonoid, specifically blocks activation of nuclear factor-κB (NF-κB). We examined the effects of…”
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Increased neuronal glutathione and neuroprotection in GTRAP3-18 -deficient mice by Aoyama, Koji, Wang, Fan, Matsumura, Nobuko, Kiyonari, Hiroshi, Shioi, Go, Tanaka, Karo, Kinoshita, Chisato, Kikuchi-Utsumi, Kazue, Watabe, Masahiko, Nakaki, Toshio

“…Abstract Glutathione (GSH) is an important neuroprotective molecule in the brain. The strategy to increase neuronal GSH level is a promising approach to the…”
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