Search Results - "NAKAJIMA, Yuka"
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Spermidine activates mitochondrial trifunctional protein and improves antitumor immunity in mice
Published in Science (American Association for the Advancement of Science) (28-10-2022)“…Spermidine (SPD) delays age-related pathologies in various organisms. SPD supplementation overcame the impaired immunotherapy against tumors in aged mice by…”
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Comparing the Effect of Animal-Rearing Education in Japan with Conventional Animal-Assisted Education
Published in Frontiers in veterinary science (07-06-2017)“…An increasing number of teachers are introducing animals into their class so that pupils foster cognitive, physiological, and social skills through their…”
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Computational screening of cryoprotective agents for regenerative medical products using quantum chemistry and molecular dynamics simulations
Published in Cryobiology (01-06-2021)“…Cryoprotective agents (CPAs) are essential for the cryopreservation of cells. Thus far, dimethyl sulfoxide (DMSO) has been widely used as a CPA; however, DMSO…”
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NML-mediated rRNA base methylation links ribosomal subunit formation to cell proliferation in a p53-dependent manner
Published in Journal of cell science (15-06-2016)“…Ribosomal RNAs (rRNAs) act as scaffolds and ribozymes in ribosomes, and these functions are modulated by post-transcriptional modifications. However, the…”
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Japan’s Low-growth Economy from the Viewpoint of Energy Quality
Published in International journal of energy economics and policy (19-01-2022)“…To investigate the possible cause of Japan’s low-growth economy, we analyze the correlation between the quality of energy and economic production such as…”
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Beneficial Effects of the Genus Aloe on Wound Healing, Cell Proliferation, and Differentiation of Epidermal Keratinocytes
Published in PloS one (13-10-2016)“…Aloe has been used as a folk medicine because it has several important therapeutic properties. These include wound and burn healing, and Aloe is now used in a…”
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BNIP3 upregulation via stimulation of ERK and JNK activity is required for the protection of keratinocytes from UVB-induced apoptosis
Published in Cell death & disease (02-02-2017)“…The human skin has an important role in barrier function. Ultraviolet rays (UV) from sunlight exposure can cause cell apoptosis in the skin epidermis,…”
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Analysis of the effect of brexpiprazole on sleep architecture in patients with schizophrenia: A preliminary study
Published in Neuropsychopharmacology reports (01-03-2023)“…Background Brexpiprazole is an atypical antipsychotic drug widely used in Japan for the treatment of schizophrenia. Previous studies have investigated the…”
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The ubiquitin ligase CHIP acts as an upstream regulator of oncogenic pathways
Published in Nature cell biology (01-03-2009)“…CHIP is a U-box-type ubiquitin ligase that induces ubiquitylation and degradation of its substrates, which include several oncogenic proteins. The relationship…”
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Estrogen and antiestrogens alter breast cancer invasiveness by modulating the transforming growth factor‐β signaling pathway
Published in Cancer science (01-08-2011)“…In the later stages of breast cancer, estrogen receptor (ER)α‐negative cancers typically have higher histological grades than ERα‐positive cancers, and…”
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Nucleomethylin deficiency impairs embryonic erythropoiesis
Published in Journal of biochemistry (Tokyo) (01-05-2018)“…Nucleomethylin (NML) has been shown to contribute to ribosome formation through regulating transcription and post-transcriptional modification of rRNA. Based…”
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A Newly Developed Method-Based Xanthine Oxidoreductase Activities in Various Human Liver Diseases
Published in Biomedicines (14-05-2023)“…Studies evaluating xanthine oxidoreductase (XOR) activities in comprehensive liver diseases are scarce, and different etiologies have previously been combined…”
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Hepatic rRNA Transcription Regulates High-Fat-Diet-Induced Obesity
Published in Cell reports (Cambridge) (01-05-2014)“…Ribosome biosynthesis is a major intracellular energy-consuming process. We previously identified a nucleolar factor, nucleomethylin (NML), which regulates…”
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The E3 ubiquitin ligase activity of Trip12 is essential for mouse embryogenesis
Published in PloS one (18-10-2011)“…Protein ubiquitination is a post-translational protein modification that regulates many biological conditions. Trip12 is a HECT-type E3 ubiquitin ligase that…”
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Nonalcoholic fatty liver disease in Japanese patients with severe obesity who received laparoscopic Roux-en-Y gastric bypass surgery (LRYGB) in comparison to non-Japanese patients
Published in Journal of gastroenterology (2008)“…Background. The number of patients with morbid obesity is increasing worldwide. However, the prevalence of morbid obesity is still low in Japan, and therefore…”
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Spatial and temporal expression of two transcriptional isoforms of Lhx3, a LIM class homeobox gene, during embryogenesis of two phylogenetically remote ascidians, Halocynthia roretzi and Ciona intestinalis
Published in Gene Expression Patterns (01-02-2010)“…Lhx3 genes are members of one of the six subfamilies of the LIM class homeobox genes. In ascidians, Lhx3 is known to play a critical role in endoderm…”
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Critical role of the CD44lowCD62Llow CD8⁺ T cell subset in restoring antitumor immunity in aged mice
Published in Proceedings of the National Academy of Sciences - PNAS (08-06-2021)“…CD8⁺ T cells play a central role in antitumor immune responses that kill cancer cells directly. In aged individuals, CD8⁺ T cell immunity is strongly…”
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Bromocriptine inhibits salsolinol‐induced prolactin release in male goats
Published in Animal science journal (01-01-2012)“…The secretion of prolactin (PRL) is under the dominant and tonic inhibitory control of dopamine (DA); however, we have recently found that salsolinol (SAL), an…”
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Photophysical Properties of Intramolecular Charge-Transfer Excited Singlet State of Aminofluorenone Derivatives
Published in The journal of physical chemistry. A, Molecules, spectroscopy, kinetics, environment, & general theory (30-04-1998)“…Photophysical properties of fluorenone and 12 aminofluorenone derivatives were investigated systematically by fluorescence quantum yield and picosecond…”
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