Search Results - "NAKAJIMA, Mitsunari"

Cloperastine Reduces IL-6 Expression via Akt/GSK3/Nrf2 Signaling in Monocytes/Macrophages and Ameliorates Symptoms in a Mouse Sepsis Model Induced by Lipopolysaccharide by Kawamura, Ayumi, Sawamoto, Atsushi, Okuyama, Satoshi, Nakajima, Mitsunari

“…Cloperastine (CLP) is a drug with a central antitussive effect that is used to treat bronchitis. Therefore, we have attempted to examine the anti-inflammatory…”
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T-Cell Activation-Inhibitory Assay to Screen Caloric Restriction Mimetics Drugs for Drug Repositioning by Ishikawa, Shouma, Sawamoto, Atsushi, Okuyama, Satoshi, Nakajima, Mitsunari

“…We previously reported a screening method for caloric restriction mimetics (CRM), a group of plant-derived compounds capable of inducing good health and…”
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Ibudilast Reduces IL-6 Levels and Ameliorates Symptoms in Lipopolysaccharide-Induced Sepsis Mice by Kadota, Naoko, Yoshida, Akari, Sawamoto, Atsushi, Okuyama, Satoshi, Nakajima, Mitsunari

“…In Japan, ibudilast (IBD) is a therapeutic agent used to treat asthma, allergic conjunctivitis, and dizziness caused by cerebrovascular disease. Previously, we…”
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Identification of the characteristic components in walnut and anti-inflammatory effect of glansreginin A as an indicator for quality evaluation by Haramiishi, Rie, Okuyama, Satoshi, Yoshimura, Morio, Nakajima, Mitsunari, Furukawa, Yoshiko, Ito, Hideyuki, Amakura, Yoshiaki

“…Walnut is a nutritious food material, but only a few studies have been conducted on the mechanisms of its functions and the technique for quality evaluation…”
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3,5,6,7,8,3',4'-Heptamethoxyflavone, a Citrus Flavonoid, Ameliorates Corticosterone-Induced Depression-like Behavior and Restores Brain-Derived Neurotrophic Factor Expression, Neurogenesis, and Neuroplasticity in the Hippocampus by Sawamoto, Atsushi, Okuyama, Satoshi, Yamamoto, Kana, Amakura, Yoshiaki, Yoshimura, Morio, Nakajima, Mitsunari, Furukawa, Yoshiko

“…We previously reported that the citrus flavonoid 3,5,6,7,8,3',4'-heptamethoxyflavone (HMF) increased the expression of brain-derived neurotrophic factor (BDNF)…”
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Anti-inflammatory and neuroprotective effects of auraptene, a citrus coumarin, following cerebral global ischemia in mice by Okuyama, Satoshi, Minami, Sona, Shimada, Naoko, Makihata, Nahomi, Nakajima, Mitsunari, Furukawa, Yoshiko

“…Cerebral ischemia causes delayed neuronal cell death in the hippocampus resulting in sequential cognitive impairments. Hyper-activated inflammation following…”
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Neuroprotective effect of Citrus kawachiensis (Kawachi Bankan) peels, a rich source of naringin, against global cerebral ischemia/reperfusion injury in mice by Okuyama, Satoshi, Yamamoto, Kana, Mori, Hirotomo, Sawamoto, Atsushi, Amakura, Yoshiaki, Yoshimura, Morio, Tamanaha, Arisa, Ohkubo, Yuu, Sugawara, Kuniaki, Sudo, Masahiko, Nakajima, Mitsunari, Furukawa, Yoshiko

“…Cerebral ischemia/reperfusion is known to induce the generation of reactive oxygen species and inflammatory responses. Numerous studies have demonstrated that…”
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Suppressive effects of the peel of Citrus kawachiensis (Kawachi Bankan) on astroglial activation, tau phosphorylation, and inhibition of neurogenesis in the hippocampus of type 2 diabetic db/db mice by Okuyama, Satoshi, Shinoka, Wakana, Nakamura, Kumi, Kotani, Maho, Sawamoto, Atsushi, Sugawara, Kuniaki, Sudo, Masahiko, Nakajima, Mitsunari, Furukawa, Yoshiko

“…We previously reported that the dried peel powder of Citrus kawachiensis exerted anti-inflammatory effects in the brain in several animal models. Hyperglycemia…”
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The peel of Citrus kawachiensis (kawachi bankan) ameliorates microglial activation, tau hyper-phosphorylation, and suppression of neurogenesis in the hippocampus of senescence-accelerated mice by Okuyama, Satoshi, Kotani, Yoshimi, Yamamoto, Kana, Sawamoto, Atsushi, Sugawara, Kuniaki, Sudo, Masahiko, Ohkubo, Yuu, Tamanaha, Arisa, Nakajima, Mitsunari, Furukawa, Yoshiko

“…Abstract We previously reported that the dried peel powder of Citrus kawachiensis, one of the citrus products of Ehime, Japan, exerted anti-inflammatory…”
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3,5,6,7,8,3',4'-Heptamethoxyflavone Ameliorates Depressive-Like Behavior and Hippocampal Neurochemical Changes in Chronic Unpredictable Mild Stressed Mice by Regulating the Brain-Derived Neurotrophic Factor: Requirement for ERK Activation by Sawamoto, Atsushi, Okuyama, Satoshi, Amakura, Yoshiaki, Yoshimura, Morio, Yamada, Takashi, Yokogoshi, Hidehiko, Nakajima, Mitsunari, Furukawa, Yoshiko

“…We previously reported that the subcutaneous administration of 3,5,6,7,8,3',4'-heptamethoxyflavone (HMF), a citrus polymethoxyflavone, attenuated…”
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Auraptene/Naringin-Rich Fruit Juice of Citrus kawachiensis (Kawachi Bankan) Prevents Ischemia-Induced Neuronal Cell Death in Mouse Brain through Anti-Inflammatory Responses by OKUYAMA, Satoshi, KATOH, Mako, KANZAKI, Tomoko, KOTANI, Yoshimi, AMAKURA, Yoshiaki, YOSHIMURA, Morio, FUKUDA, Naohiro, TAMAI, Takahisa, SAWAMOTO, Atsushi, NAKAJIMA, Mitsunari, FURUKAWA, Yoshiko

“…Cerebral ischemia/reperfusion leads to delayed neuronal cell death, resulting in brain damage. Auraptene (AUR) and naringin (NGIN), which exert neuroprotective…”
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Isolation and Characterization of Neuroprotective Components from Citrus Peel and Their Application as Functional Food by Furukawa, Yoshiko, Okuyama, Satoshi, Amakura, Yoshiaki, Sawamoto, Atsushi, Nakajima, Mitsunari, Yoshimura, Morio, Igase, Michiya, Fukuda, Naohiro, Tamai, Takahisa, Yoshida, Takashi

“…The elderly experience numerous physiological alterations. In the brain, aging causes degeneration or loss of distinct populations of neurons, resulting in…”
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Citrus Auraptene Induces Expression of Brain-Derived Neurotrophic Factor in Neuro2a Cells by Furukawa, Yoshiko, Washimi, Yu-Suke, Hara, Ryu-Ichi, Yamaoka, Mizuki, Okuyama, Satoshi, Sawamoto, Atsushi, Nakajima, Mitsunari

“…(1) Background: Our published data have indicated that 1) auraptene (AUR), a citrus ingredient, has neuroprotective effects on the mouse brain, owing to its…”
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Auraptene Acts as an Anti-Inflammatory Agent in the Mouse Brain by Okuyama, Satoshi, Morita, Mayu, Kaji, Miki, Amakura, Yoshiaki, Yoshimura, Morio, Shimamoto, Koji, Ookido, Yu, Nakajima, Mitsunari, Furukawa, Yoshiko

“…The anti-inflammatory activity of auraptene (AUR), a citrus coumarin, in peripheral tissues is well-known, and we previously demonstrated that AUR exerts…”
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Effects of Carbazole Derivatives on Neurite Outgrowth and Hydrogen Peroxide-Induced Cytotoxicity in Neuro2a Cells by Furukawa, Yoshiko, Sawamoto, Atsushi, Yamaoka, Mizuki, Nakaya, Makiko, Hieda, Yuhzo, Choshi, Tominari, Hatae, Noriyuki, Okuyama, Satoshi, Nakajima, Mitsunari, Hibino, Satoshi

“…Many studies have demonstrated that oxidative stress plays an important role in several ailments including neurodegenerative diseases and cerebral ischemic…”
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Effects of Citrus kawachiensis Peel in Frailty-like Model Mice Induced by Low Protein Nutrition Disorders by Omasa, Toshiki, Okuyama, Satoshi, Sawamoto, Atsushi, Nakajima, Mitsunari, Furukawa, Yoshiko

“…"Frailty" caused by a decline in physiological reserve capacity, chronic inflammation, and oxidative stress in the elderly has recently become a major social…”
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Citrus Auraptene Induces Glial Cell Line-Derived Neurotrophic Factor in C6 Cells by Furukawa, Yoshiko, Hara, Ryu-Ichi, Nakaya, Makiko, Okuyama, Satoshi, Sawamoto, Atsushi, Nakajima, Mitsunari

“…We previously demonstrated that auraptene (AUR), a natural coumarin derived from citrus plants, exerts anti-inflammatory effects in the brain, resulting in…”
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Auraptene and Other Prenyloxyphenylpropanoids Suppress Microglial Activation and Dopaminergic Neuronal Cell Death in a Lipopolysaccharide-Induced Model of Parkinson's Disease by Okuyama, Satoshi, Semba, Tomoki, Toyoda, Nobuki, Epifano, Francesco, Genovese, Salvatore, Fiorito, Serena, Taddeo, Vito Alessandro, Sawamoto, Atsushi, Nakajima, Mitsunari, Furukawa, Yoshiko

“…In patients with Parkinson's disease (PD), hyperactivated inflammation in the brain, particularly microglial hyperactivation in the substantia nigra (SN), is…”
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Activation of Extracellular Signal-Regulated Kinase 2 and cAMP Response Element-Binding Protein in Cultured Neurons by the Macrocyclic Ellagitannin Oenothein B by Okuyama, Satoshi, Yoshimura, Morio, Amakura, Yoshiaki, Nakajima, Mitsunari, Furukawa, Yoshiko

“…(1) Background: The findings of our recent in vivo study indicated that the oral administration of oenothein B, a unique macrocyclic ellagitannin, activated…”
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Continual Treatment with the Peels of Citrus kawachiensis (Kawachi Bankan) Protects against Dopaminergic Neuronal Cell Death in a Lipopolysaccharide-Induced Model of Parkinson’s Disease by OKUYAMA, Satoshi, KANZAKI, Tomoko, KOTANI, Yoshimi, KATOH, Mako, SAWAMOTO, Atsushi, NAKAJIMA, Mitsunari, FURUKAWA, Yoshiko

“…Our previous study showed that the subcutaneous administration of auraptene (AUR) suppresses inflammatory responses including the hyperactivation of microglia…”
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