Search Results - "NAKAE, J"

The LXXLL motif of murine forkhead transcription factor FoxO1 mediates Sirt1-dependent transcriptional activity by Nakae, Jun, Cao, Yongheng, Daitoku, Hiroaki, Fukamizu, Akiyoshi, Ogawa, Wataru, Yano, Yoshihiko, Hayashi, Yoshitake

“…The forkhead transcription factor FoxO1 has been identified as a negative regulator of insulin/IGF-1 signaling. Its function is inhibited by phosphorylation…”
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Insulin/Foxo1 Pathway Regulates Expression Levels of Adiponectin Receptors and Adiponectin Sensitivity by Tsuchida, Atsushi, Yamauchi, Toshimasa, Ito, Yusuke, Hada, Yusuke, Maki, Toshiyuki, Takekawa, Sato, Kamon, Junji, Kobayashi, Masaki, Suzuki, Ryo, Hara, Kazuo, Kubota, Naoto, Terauchi, Yasuo, Froguel, Philippe, Nakae, Jun, Kasuga, Masato, Accili, Domenico, Tobe, Kazuyuki, Ueki, Kohjiro, Nagai, Ryozo, Kadowaki, Takashi

“…Adiponectin/Acrp30 is a hormone secreted by adipocytes, which acts as an antidiabetic and antiatherogenic adipokine. We reported previously that AdipoR1 and…”
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P53 Continuous activation of IGF signaling inhibits myogenic differentiation of L6 myoblasts by Hakuno, F, Kaneko, G, Yamauchi, Y, Chida, K, Nakae, J, Takahashi, S.-I

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OR8,4 Overexpression of IRS-1 suppresses initiation of myogenesis through exclusion of Foxo1 from the nucleus in the PI 3-kinase-dependent mechanism by Yamauchi, Y, Kaneko, G, Okajima, H, Kadowaki, T, Yamanouchi, K, Nakae, J, Hakuno, F, Takahashi, S-I

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Targeted gene mutations define the roles of insulin and IGF-I receptors in mouse embryonic development by Accili, D, Nakae, J, Kim, J J, Park, B C, Rother, K I

“…Insulin-like growth factors (IGFs) and their receptors regulate embryonic and post-natal growth. Genetic evidence derived from targeted mouse mutants indicates…”
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Truncation at the C-terminus of the DAX-1 protein impairs its biological actions in patients with X-linked adrenal hypoplasia congenita by NAKAE, J, TAJIMA, T, FUJIEDA, K, KUSUDA, S, KOHDA, N, OKABE, T, SHINOHARA, N, KATO, M, MURASHITA, M, MUKAI, T, IMANAKA, K

“…The DAX-1 [DSS (dosage-sensitive sex)-AHC critical region in the X, gene 1] gene has been reported to be responsible for X-linked adrenal hypoplasia congenita…”
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The FoxO transcription factors and metabolic regulation by Nakae, Jun, Oki, Miyo, Cao, Yongheng

“…Forkhead transcription factors FoxOs are conserved beyond species and regulated by insulin signaling pathway. FoxOs have diverse functions on differentiation,…”
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Tissue-specific insulin resistance in type 2 diabetes: lessons from gene-targeted mice by Nakae, J, Kido, Y, Accili, D

“…Type 2 diabetes is caused by genetic and environmental factors that affect the ability of the organism to respond to insulin. This impairment results from…”
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Distinct and Overlapping Functions of Insulin and IGF-I Receptors by Nakae, Jun, Kido, Yoshiaki, Accili, Domenico

“…Targeted gene mutations have established distinct, yet overlapping, developmental roles for receptors of the insulin/IGF family. IGF-I receptor mediates IGF-I…”
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Two mutations of the Gsα gene in two Japanese patients with sporadic pseudohypoparathyroidism type Ia by Ishikawa, Y., Tajima, T., Nakae, J., Nagashima, T., Satoh, K., Okuhara, K., Fujieda, K.

“…Pseudohypoparathyroidism Ia (PHP-Ia), is an inherited disease with clinical hypoparathyroidism caused by parathyroid hormone resistance (PTH), and shows the…”
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The Forkhead Transcription Factor Foxo1 Regulates Adipocyte Differentiation by Nakae, Jun, Kitamura, Tadahiro, Kitamura, Yukari, Biggs, William H., Arden, Karen C., Accili, Domenico

“…An outstanding question in adipocyte biology is how hormonal cues are relayed to the nucleus to activate the transcriptional program that promotes…”
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Clinical review 125: The insulin receptor and its cellular targets by Kido, Y, Nakae, J, Accili, D

“…The pleiotropic actions of insulin are mediated by a single receptor tyrosine kinase. Structure/function relationships of the insulin receptor have been…”
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The forkhead transcription factor Foxo1 (Fkhr) confers insulin sensitivity onto glucose-6-phosphatase expression by Nakae, J, Kitamura, T, Silver, D L, Accili, D

“…Type 2 diabetes is characterized by the inability of insulin to suppress glucose production in the liver and kidney. Insulin inhibits glucose production by…”
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Differential regulation of gene expression by insulin and IGF-1 receptors correlates with phosphorylation of a single amino acid residue in the forkhead transcription factor FKHR by Nakae, Jun, Barr, Valarie, Accili, Domenico

“…The transcription factor FKHR is inhibited by phosphorylation in response to insulin and IGF‐1 through Akt kinase. Here we show that FKHR phosphorylation in…”
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Regulation of insulin action and pancreatic β-cell function by mutated alleles of the gene encoding forkhead transcription factor Foxo1 by Accili, Domenico, Nakae, Jun, Biggs, William H, Kitamura, Tadahiro, Cavenee, Webster K, Wright, Christopher V.E, Arden, Karen C

“…Type 2 diabetes results from impaired action and secretion of insulin. It is not known whether the two defects share a common pathogenesis. We show that…”
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The forkhead transcription factor Foxo1 links insulin signaling to Pdx1 regulation of pancreatic beta cell growth by Kitamura, Tadahiro, Nakae, Jun, Kitamura, Yukari, Kido, Yoshiaki, Biggs, 3rd, William H, Wright, Christopher V E, White, Morris F, Arden, Karen C, Accili, Domenico

“…Diabetes is caused by an absolute (type 1) or relative (type 2) deficiency of insulin-producing beta cells. The mechanisms governing replication of terminally…”
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Involvement of SIK3 in glucose and lipid homeostasis in mice by Uebi, Tatsuya, Itoh, Yumi, Hatano, Osamu, Kumagai, Ayako, Sanosaka, Masato, Sasaki, Tsutomu, Sasagawa, Satoru, Doi, Junko, Tatsumi, Keita, Mitamura, Kuniko, Morii, Eiichi, Aozasa, Katsuyuki, Kawamura, Tomohiro, Okumura, Meinoshin, Nakae, Jun, Takikawa, Hajime, Fukusato, Toshio, Koura, Minako, Nish, Mayumi, Hamsten, Anders, Silveira, Angela, Bertorello, Alejandro M, Kitagawa, Kazuo, Nagaoka, Yasuo, Kawahara, Hidehisa, Tomonaga, Takeshi, Naka, Tetsuji, Ikegawa, Shigeo, Tsumaki, Noriyuki, Matsuda, Junichiro, Takemori, Hiroshi

“…Salt-inducible kinase 3 (SIK3), an AMP-activated protein kinase-related kinase, is induced in the murine liver after the consumption of a diet rich in fat,…”
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Insulin Stimulates Phosphorylation of the Forkhead Transcription Factor FKHR on Serine 253 through a Wortmannin-sensitive Pathway by Nakae, J, Park, B C, Accili, D

“…In the nematode Caenorhabditis elegans , mutations of the insulin/insulin-like growth factor-1 receptor homologue Daf-2 gene cause developmental arrest at the…”
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Transgenic rescue of insulin receptor-deficient mice by Okamoto, Haruka, Nakae, Jun, Kitamura, Tadahiro, Park, Byung-Chul, Dragatsis, Ioannis, Accili, Domenico

“…The role of different tissues in insulin action and their contribution to the pathogenesis of diabetes remain unclear. To examine this question, we have used…”
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Inhibition of Foxo1 function is associated with improved fasting glycemia in diabetic mice by Altomonte, Jennifer, Richter, Anja, Harbaran, Sonal, Suriawinata, Jenny, Nakae, Jun, Thung, Swan N, Meseck, Marcia, Accili, Domenico, Dong, Hengjiang

“…Excessive hepatic glucose production is a contributing factor to fasting hyperglycemia in diabetes. Insulin suppresses hepatic glucose production by inhibiting…”
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