Search Results - "NAJAJREH, Y"
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Novel PDGFβR antisense encapsulated in polymeric nanospheres for the treatment of restenosis
Published in Gene therapy (01-12-2002)“…Nanospheres composed of the biocompatible and biodegradable polymer, poly-DL-lactide/glycolide and containing platelet-derived growth factor β-receptor…”
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2
DNA Binding Mode of the Cis and Trans Geometries of New Antitumor Nonclassical Platinum Complexes Containing Piperidine, Piperazine, or 4-Picoline Ligand in Cell-Free Media. Relations to Their Activity in Cancer Cell Lines
Published in Biochemistry (Easton) (27-05-2003)“…The global modification of mammalian and plasmid DNAs by novel platinum compounds, cis- or trans-[PtCl2(NH3)(Am)], where Am = NH3, nonplanar heterocycle…”
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3
Interactions of cisplatin and transplatin with proteins. Comparison of binding kinetics, binding sites and reactivity of the Pt-protein adducts of cisplatin and transplatin towards biological nucleophiles
Published in Journal of inorganic biochemistry (25-07-2002)“…In this manuscript we report on the interactions of cis-DDP (cisplatin, cis-diamminedichloroplatinum(II)) and trans-DDP (transplatin,…”
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4
Novel Apoptosis-Inducing trans-Platinum Piperidine Derivatives: Synthesis and Biological Characterization
Published in Journal of medicinal chemistry (21-11-2002)“…The synthesis, chemical characterization, and interaction with cells of new sterically hindered trans- and cis-diaminedichloroplatinum(II) complexes are…”
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5
Novel Soluble Cationic trans-Diaminedichloroplatinum(II) Complexes that Are Active against Cisplatin Resistant Ovarian Cancer Cell Lines
Published in Journal of medicinal chemistry (21-11-2002)“…Positively charged, water soluble cis/trans-[PtCl2(piperazine)(Am1)] (where Am1 = NH3, n-butylamine, isopropylamine, 4-picoline, piperidine, and piperazine)…”
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6
Oleic Acid Is the Active Component in the Mushroom Daedalea gibbosa Inhibiting Bcr-Abl Kinase Autophosphorylation Activity
Published in Anticancer research (2011)“…The hallmark of chronic myeloid leukemia (CML) is the abnormal activity of p210(Bcr-Abl) kinase. Selective kinase inhibitors such as imatinib or nilotinib have…”
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7
Activation of trans geometry in bifunctional mononuclear platinum complexes by a piperidine ligand. Mechanistic studies on antitumor action
Published in The Journal of biological chemistry (28-11-2003)“…A paradigm for the structure-pharmacological activity relationship of bifunctional platinum antitumor drugs is that the trans isomer of antitumor cisplatin…”
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8
Structural characterization and DNA interactions of new cytotoxic transplatin analogues containing one planar and one nonplanar heterocyclic amine ligand
Published in Journal of biological inorganic chemistry (01-11-2005)“…trans-Diaminedicholoroplatinum(II) complexes with one planar and one non-planar heterocyclic amine ligand were designed as new potential antitumor drugs. The…”
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9
p185BCR/ABL has a lower sensitivity than p210BCR/ABL to the allosteric inhibitor GNF-2 in Philadelphia chromosome-positive acute lymphatic leukemia
Published in Haematologica (Roma) (01-02-2012)“…Background The t(9;22) translocation leads to the formation of the chimeric breakpoint cluster region/c-abl oncogene 1 (BCR/ABL) fusion gene on der22, the…”
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10
Structure and Unique Interactions with DNA of a Cationic Trans-Platinum Complex with the Nonplanar Bicyclic Piperidinopiperidine Ligand
Published in Angewandte Chemie International Edition (06-05-2005)“…Circumventing cisplatin resistance: The trans‐[PtCl2(NH3)(pip‐pip)]+ ion (see structure; red Pt, blue N, green Cl, gray C) is a cytotoxic compound with a…”
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11
Water soluble cationic trans-platinum complexes which induce programmed cell death in the protozoan parasite Leishmania infantum
Published in Journal of inorganic biochemistry (01-03-2005)“…We have evaluated the cytotoxic properties against the protozoan Leishmania infantum of four water soluble cationic trans-Pt(II)Cl 2 compounds containing as…”
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12
Ligand effects on the binding of cis- and trans-[PtCl(2)Am(1)Am(2)] to proteins
Published in Journal of biological inorganic chemistry (01-01-2003)“…As part of a systematic study of the basic principles that govern the formation and reactivity of Pt-protein adducts, we report the effect of substituting the…”
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13
Decreased levels of osteopontin and bone sialoprotein II are correlated with reduced proliferation, colony formation, and migration of GFP-MDA-MB-231 cells
Published in International journal of oncology (01-05-2004)“…MDA-MB-231 human breast cancer cells transfected with GFP were used as model to determine the reduction in proliferation, colony formation, and migration in…”
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14
Preparation, cytotoxicity and interactions with nucleophiles of three isomeric transplatinum complexes containing methylpiperidine ligands
Published in Journal of inorganic biochemistry (01-10-2005)“…Three isomeric complexes, trans-[PtCl 2(NH 3)(2-methylpiperidine)], trans-[PtCl 2(NH 3)(3-methylpiperidine)] and trans-[PtCl 2(NH 3)(4-methylpiperidine)], were…”
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15
Effects of a Piperidine Ligand on DNA Modification by Antitumor Cisplatin Analogues
Published in Chemical research in toxicology (01-11-2003)“…Replacement of the ammine group in antitumor cisplatin by a heterocyclic ligand (piperidine, piperazine, or 4-picoline) results in reduction of cytotoxicity in…”
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16
Novel PDGFbetaR antisense encapsulated in polymeric nanospheres for the treatment of restenosis
Published in Gene therapy (01-12-2002)“…Nanospheres composed of the biocompatible and biodegradable polymer, poly-DL-lactide/glycolide and containing platelet-derived growth factor beta-receptor…”
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Journal Article -
17
Novel PDGFssR antisense encapsulated in polymeric nanospheres for the treatment of restenosis
Published in Gene therapy (01-12-2002)“…Nanospheres composed of the biocompatible and biodegradable polymer, poly-DL-lactide/glycolide and containing platelet-derived growth factor beta -receptor…”
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18
Novel PDGF[beta]R antisense encapsulated in polymeric nanospheres for the treatment of restenosis
Published in Gene therapy (01-12-2002)“…Nanospheres composed of the biocompatible and biodegradable polymer, poly-DL-lactide/glycolide and containing platelet-derived growth factor beta-receptor…”
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