Search Results - "NAJAJREH, Y"

  • Showing 1 - 18 results of 18
Refine Results
  1. 1

    Novel PDGFβR antisense encapsulated in polymeric nanospheres for the treatment of restenosis by COHEN-SACKS, H, NAJAJREH, Y, TCHAIKOVSKI, V, GAO, G, ELAZER, V, DAHAN, R, GATI, I, KANAAN, M, WALTENBERGER, J, GOLOMB, G

    Published in Gene therapy (01-12-2002)
    “…Nanospheres composed of the biocompatible and biodegradable polymer, poly-DL-lactide/glycolide and containing platelet-derived growth factor β-receptor…”
    Get full text
    Journal Article
  2. 2
  3. 3
  4. 4

    Novel Apoptosis-Inducing trans-Platinum Piperidine Derivatives:  Synthesis and Biological Characterization by Khazanov, Elena, Barenholz, Yechezkel, Gibson, Dan, Najajreh, Yousef

    Published in Journal of medicinal chemistry (21-11-2002)
    “…The synthesis, chemical characterization, and interaction with cells of new sterically hindered trans- and cis-diaminedichloroplatinum(II) complexes are…”
    Get full text
    Journal Article
  5. 5

    Novel Soluble Cationic trans-Diaminedichloroplatinum(II) Complexes that Are Active against Cisplatin Resistant Ovarian Cancer Cell Lines by Najajreh, Yousef, Perez, Jose Manuel, Navarro-Ranninger, Carmen, Gibson, Dan

    Published in Journal of medicinal chemistry (21-11-2002)
    “…Positively charged, water soluble cis/trans-[PtCl2(piperazine)(Am1)] (where Am1 = NH3, n-butylamine, isopropylamine, 4-picoline, piperidine, and piperazine)…”
    Get full text
    Journal Article
  6. 6

    Oleic Acid Is the Active Component in the Mushroom Daedalea gibbosa Inhibiting Bcr-Abl Kinase Autophosphorylation Activity by KHAMAISIE, Hazem, SUSSAN, Sherbel, TAL, Michael, NAJAJREH, Yousef, RUTHARDT, Martin, MAHAJNA, Jamal

    Published in Anticancer research (2011)
    “…The hallmark of chronic myeloid leukemia (CML) is the abnormal activity of p210(Bcr-Abl) kinase. Selective kinase inhibitors such as imatinib or nilotinib have…”
    Get full text
    Journal Article
  7. 7

    Activation of trans geometry in bifunctional mononuclear platinum complexes by a piperidine ligand. Mechanistic studies on antitumor action by Kasparkova, Jana, Novakova, Olga, Marini, Victoria, Najajreh, Yousef, Gibson, Dan, Perez, Jose-Manuel, Brabec, Viktor

    Published in The Journal of biological chemistry (28-11-2003)
    “…A paradigm for the structure-pharmacological activity relationship of bifunctional platinum antitumor drugs is that the trans isomer of antitumor cisplatin…”
    Get full text
    Journal Article
  8. 8

    Structural characterization and DNA interactions of new cytotoxic transplatin analogues containing one planar and one nonplanar heterocyclic amine ligand by Najajreh, Yousef, Kasparkova, Jana, Marini, Victoria, Gibson, Dan, Brabec, Viktor

    Published in Journal of biological inorganic chemistry (01-11-2005)
    “…trans-Diaminedicholoroplatinum(II) complexes with one planar and one non-planar heterocyclic amine ligand were designed as new potential antitumor drugs. The…”
    Get full text
    Journal Article
  9. 9

    p185BCR/ABL has a lower sensitivity than p210BCR/ABL to the allosteric inhibitor GNF-2 in Philadelphia chromosome-positive acute lymphatic leukemia by MIAN, Afsar A, METODIEVA, Anna, NAJAJREH, Yousef, OTTMANN, Oliver G, MAHAJNA, Jamal, RUTHARDT, Martin

    Published in Haematologica (Roma) (01-02-2012)
    “…Background The t(9;22) translocation leads to the formation of the chimeric breakpoint cluster region/c-abl oncogene 1 (BCR/ABL) fusion gene on der22, the…”
    Get full text
    Journal Article
  10. 10

    Structure and Unique Interactions with DNA of a Cationic Trans-Platinum Complex with the Nonplanar Bicyclic Piperidinopiperidine Ligand by Najajreh, Yousef, Prilutski, Dmitri, Ardeli-Tzaraf, Yael, Perez, Jose Manuel, Khazanov, Elena, Barenholz, Yechezkel, Kasparkova, Jana, Brabec, Viktor, Gibson, Dan

    Published in Angewandte Chemie International Edition (06-05-2005)
    “…Circumventing cisplatin resistance: The trans‐[PtCl2(NH3)(pip‐pip)]+ ion (see structure; red Pt, blue N, green Cl, gray C) is a cytotoxic compound with a…”
    Get full text
    Journal Article
  11. 11

    Water soluble cationic trans-platinum complexes which induce programmed cell death in the protozoan parasite Leishmania infantum by Nguewa, Paul A., Fuertes, Miguel A., Iborra, Salvador, Najajreh, Yousef, Gibson, Dani, Martínez, Enrique, Alonso, Carlos, Pérez, José M.

    Published in Journal of inorganic biochemistry (01-03-2005)
    “…We have evaluated the cytotoxic properties against the protozoan Leishmania infantum of four water soluble cationic trans-Pt(II)Cl 2 compounds containing as…”
    Get full text
    Journal Article
  12. 12

    Ligand effects on the binding of cis- and trans-[PtCl(2)Am(1)Am(2)] to proteins by Najajreh, Yousef, Peleg-Shulman, Tal, Moshel, Ofra, Farrell, Nicholas, Gibson, Dan

    Published in Journal of biological inorganic chemistry (01-01-2003)
    “…As part of a systematic study of the basic principles that govern the formation and reactivity of Pt-protein adducts, we report the effect of substituting the…”
    Get full text
    Journal Article
  13. 13

    Decreased levels of osteopontin and bone sialoprotein II are correlated with reduced proliferation, colony formation, and migration of GFP-MDA-MB-231 cells by Adwan, Hassan, Bäuerle, Tobias, Najajreh, Yousef, Elazer, Victoria, Golomb, Gershon, Berger, Martin R

    Published in International journal of oncology (01-05-2004)
    “…MDA-MB-231 human breast cancer cells transfected with GFP were used as model to determine the reduction in proliferation, colony formation, and migration in…”
    Get more information
    Journal Article
  14. 14

    Preparation, cytotoxicity and interactions with nucleophiles of three isomeric transplatinum complexes containing methylpiperidine ligands by Jawbry, Seba, Freikman, Inna, Najajreh, Yousef, Perez, Jose Manuel, Gibson, Dan

    Published in Journal of inorganic biochemistry (01-10-2005)
    “…Three isomeric complexes, trans-[PtCl 2(NH 3)(2-methylpiperidine)], trans-[PtCl 2(NH 3)(3-methylpiperidine)] and trans-[PtCl 2(NH 3)(4-methylpiperidine)], were…”
    Get full text
    Journal Article
  15. 15

    Effects of a Piperidine Ligand on DNA Modification by Antitumor Cisplatin Analogues by Kasparkova, Jana, Novakova, Olga, Najajreh, Yousef, Gibson, Dan, Perez, Jose-Manuel, Brabec, Viktor

    Published in Chemical research in toxicology (01-11-2003)
    “…Replacement of the ammine group in antitumor cisplatin by a heterocyclic ligand (piperidine, piperazine, or 4-picoline) results in reduction of cytotoxicity in…”
    Get full text
    Journal Article
  16. 16

    Novel PDGFbetaR antisense encapsulated in polymeric nanospheres for the treatment of restenosis by Cohen-Sacks, H, Najajreh, Y, Tchaikovski, V, Gao, G, Elazer, V, Dahan, R, Gati, I, Kanaan, M, Waltenberger, J, Golomb, G

    Published in Gene therapy (01-12-2002)
    “…Nanospheres composed of the biocompatible and biodegradable polymer, poly-DL-lactide/glycolide and containing platelet-derived growth factor beta-receptor…”
    Get full text
    Journal Article
  17. 17

    Novel PDGFssR antisense encapsulated in polymeric nanospheres for the treatment of restenosis by Cohen-Sacks, H, Najajreh, Y, Tchaikovski, V, Gao, G, Elazer, V, Dahan, R, Gati, I, Kanaan, M, Waltenberger, J, Golomb, G

    Published in Gene therapy (01-12-2002)
    “…Nanospheres composed of the biocompatible and biodegradable polymer, poly-DL-lactide/glycolide and containing platelet-derived growth factor beta -receptor…”
    Get full text
    Journal Article
  18. 18

    Novel PDGF[beta]R antisense encapsulated in polymeric nanospheres for the treatment of restenosis by Cohen-Sacks, H, Najajreh, Y, Tchaikovski, V, Gao, G, Elazer, V, Dahan, R, Gati, I, Kanaan, M, Waltenberger, J, Golomb, G

    Published in Gene therapy (01-12-2002)
    “…Nanospheres composed of the biocompatible and biodegradable polymer, poly-DL-lactide/glycolide and containing platelet-derived growth factor beta-receptor…”
    Get full text
    Journal Article