Search Results - "NAIR, Vasu"

Inosine monophosphate dehydrogenase (IMPDH) as a target in drug discovery by Shu, Qingning, Nair, Vasu

“…Inosine monophosphate dehydrogenase (IMPDH) is a key enzyme of de novo purine nucleotide biosynthesis and is viewed as an important target in the quest for…”
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Integrase Inhibitor Prodrugs: Approaches to Enhancing the Anti-HIV Activity of β-Diketo Acids by Nair, Vasu, Okello, Maurice

“…HIV integrase, encoded at the 3'-end of the HIV pol gene, is essential for HIV replication. This enzyme catalyzes the incorporation of HIV DNA into human DNA,…”
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HIV integrase inhibitors as therapeutic agents in AIDS by Nair, Vasu, Chi, Guochen

“…HIV‐1 integrase is a protein of Mr 32 000 encoded at the 3′‐end of the pol gene. Integration of HIV DNA into the host cell chromosomal DNA apparently occurs by…”
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Synthesis of a novel carbocyclic analog of bredinin by Nair, Vasu, Zhang, Fan

“…The natural nucleoside antibiotic, bredinin, exhibits antiviral and other biological activities. While various nucleosides related to bredinin have been…”
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Inosine Monophosphate Dehydrogenase as a Probe in Antiviral Drug Discovery by Nair, Vasu, Shu, Qingning

“…Inosine monophosphate (IMP) dehydrogenase (IMPDH) is a significant enzyme in the purine nucleotide biosynthetic pathway. IMPDH is viewed as an important…”
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Novel inhibitors of HIV integrase: the discovery of potential anti-HIV therapeutic agents by Nair, Vasu

“…The viral enzyme, HIV integrase (MW 32 kDa), is one of the three key enzymes of the pol gene of HIV. HIV integrase is involved in the integration of HIV DNA…”
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Novel HIV Integrase Inhibitors with Anti-HIV Activity: Insights into Integrase Inhibition from Docking Studies by Cox, Arthur G, Nair, Vasu

“…The mechanism of integrase is generally accepted to be dependant on the presence of two divalent metal ions in the active site. However, the only available…”
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Inhibition of inosine monophosphate dehydrogenase (IMPDH) by 2-[2-( Z)-Fluorovinyl]inosine 5′-Monophosphate by Nair, Vasu, Kamboj, Ramesh C

“…Inosine 5′-monophosphate dehydrogenase (IMPDH; EC 1.1.1.205) isolated from Escherichia coli B3 cells was strongly inhibited by 2-[2-( Z)-fluorovinyl]inosine…”
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Synthesis and antiviral studies of a novel isodideoxynucleoside: an analogue of the antiviral compound, tiazofurin by Nair, Vasu, Wenzel, Thomas

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A highly efficient procedure for the oxidation of the 5'-position of adenosine analogues by Halligan, Kathleen, Nair, Vasu

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A new method for the phosphorylation of nucleosides by Taktakishvili, Michael, Nair, Vasu

“…A new phosphorylating reagent, 2- O-(4,4′-dimethoxytrityl)ethylsulfonylethan-2′-yl-phosphate ( 1), was developed for the phosphorylation of primary and…”
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Synthesis of novel bicarbocyclic nucleosides by Nair, Vasu, Jeon, Geun-Sook

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Synthesis of the 5'-C-phosphonate of 4(S)-(6-amino-9H-purin-9-yl) tetrahydro-2(S)-furanmethanol [S,S-IsoddA] by Nair, Vasu, Sharma, Pawan K.

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Anti-Human Immunodeficiency Virus Activities of Nucleosides and Nucleotides: Correlation with Molecular Electrostatic Potential Data by MICKLE, Travis, NAIR, Vasu

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Total synthesis of hydroxymethyl isonucleosides as potential antiviral agents by Nair, Vasu, Chun, Byoung-Kwon

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Synthesis and antiviral evaluation of 2-amino-1,6-dihydro-6-oxo-9-[4-bis(hydroxymethyl) -2-cyclopenten-1-yl]-9H-purine: an analog of the anti-HIV compound Carbovir by Sharma, Pawan K., Nair, Vasu

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Isodideoxynucleosides: a conceptually new class of nucleoside antiviral agents by Nair, Vasu, Nuesca, Zoraida M

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Synthesis of Biomimetic Analogs of Neomycin B: Potential Inhibitors of the HIV RNA Rev Response Element by Nishizono, Naozumi, Nair, Vasu

“…The aminoglycosidic antibiotic, neomycin B, is an inhibitor of the binding of Rev to RRE. This paper reports on the synthesis of analogs of neomycin B as…”
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Notable difference in anti-HIV activity of integrase inhibitors as a consequence of geometric and enantiomeric configurations by Okello, Maurice, Mishra, Sanjay, Nishonov, Malik, Nair, Vasu

“…While some examples are known of integrase inhibitors that exhibit potent anti-HIV activity, there are very few cases reported of integrase inhibitors that…”
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A heterocyclic molecule with significant activity against dengue virus by Nair, Vasu, Chi, Guochen, Shu, Qingning, Julander, Justin, Smee, Donald F.

“…There are no specific approved drugs or vaccines for the treatment or prevention of infectious dengue virus and there are very few compounds known that inhibit…”
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