Search Results - "NAIR, THANKAM S."

Lack of the human choline transporter‐like protein SLC44A2 causes hearing impairment and a rare red blood phenotype by Koehl, Bérengère, Vrignaud, Cédric, Mikdar, Mahmoud, Nair, Thankam S, Yang, Lucy, Landry, Seyve, Laiguillon, Guy, Giroux‐Lathuile, Claudine, Anselme‐Martin, Sophie, El Kenz, Hanane, Hermine, Olivier, Mohandas, Narla, Cartron, Jean Pierre, Colin, Yves, Detante, Olivier, Marlu, Raphaël, Le Van Kim, Caroline, Carey, Thomas E, Azouzi, Slim, Peyrard, Thierry

“…Blood phenotypes are defined by the presence or absence of specific blood group antigens at the red blood cell (RBC) surface, due to genetic polymorphisms…”
Get full text

Characteristics of head and neck squamous cell carcinoma cell Lines reflect human tumor biology independent of primary etiologies and HPV status by Nair, Thankam S., Thomas, Trey B., Yang, Lucy, Kakaraparthi, Bala Naveen, Morris, Anna C., Clark, Alanna M., Campredon, Lora P., Brouwer, Andrew F., Eisenberg, Marisa C., Meza, Rafael, Carey, Thomas E.

“…Explanations for the differences in clinical outcomes in head and neck squamous cell carcinomas (HNSCCs) when compared by similar tumor location, stage, nodal…”
Get full text

Galanin Receptor Subtype 2 Suppresses Cell Proliferation and Induces Apoptosis in p53 Mutant Head and Neck Cancer Cells by KANAZAWA, Takeharu, KOMMAREDDI, Pavan K, IWASHITA, Toshihide, KUMAR, Bhavna, MISAWA, Kiyoshi, MISAWA, Yuki, JANG, Ilwhan, NAIR, Thankam S, IINO, Yukiko, CAREY, Thomas E

“…Purpose: Galanin and its three receptors (GALR1-3) are expressed in many normal tissues, but silenced in some tumors. Contradictory roles for galanin and its…”
Get full text

Slc44a2 deletion alters tetraspanin and N-cadherin expression: Reduced adhesion and enhanced proliferation in cultured mesenchymal lung cells by Nair, Thankam S., Kakaraparthi, Bala Naveen, Yang, Lucy, Lu, Lillian, Thomas, Trey B., Morris, Anna C., Kommareddi, Pavan, Kanicki, Ariane, Carey, Thomas E.

“…[Display omitted] •Slc44a2 is required for strong adhesion of cultured lung mesenchymal cells.•Absent or reduced Slc44a2 diminishes CD9 membrane foci in…”
Get full text

Characterization of hemostasis in mice lacking the novel thrombosis susceptibility gene Slc44a2 by Tilburg, Julia, Adili, Reheman, Nair, Thankam S., Hawley, Megan E., Tuk, David C., Jackson, Madeline, Spronk, Henri M., Versteeg, Henri H., Carey, Thomas E., van Vlijmen, Bart J.M., Maracle, Chrissta X., Holinstat, Michael

“…Recent genome wide association studies (GWAS) identified a novel susceptibility locus for thrombosis, harbouring the SLC44A2 gene which encodes the Solute…”
Get full text

SLC44A2 single nucleotide polymorphisms, isoforms, and expression: Association with severity of Meniere's disease? by Nair, Thankam S., Kommareddi, Pavan K., Galano, Maria M., Miller, Danielle M., Kakaraparthi, Bala Naveen, Telian, Steven A., Arts, H. Alex, El-Kashlan, Hussam, Kilijanczyk, Alyse, Lassig, Amy Anne D., Graham, Martin P., Fisher, Susan G., Stoll, Stefan W., Nair, Rajan P., Elder, James T., Carey, Thomas E.

“…SLC44A2 was discovered as the target of an antibody that causes hearing loss. Knockout mice develop age related hearing loss, loss of sensory cells and spiral…”
Get full text

Age-related changes in expression of CTL2/SLC44A2 and its isoforms in the mouse inner ear by Beyer, Lisa A., Galano, Maria M., Nair, Thankam S., Kommareddi, Pavan K., Sha, Su-Hua, Raphael, Yehoash, Carey, Thomas E.

“…The membrane glycoprotein CTL2/SLC44A2 is expressed by supporting cells in the inner ear and has been identified as a target of antibodies that may induce…”
Get full text

Autoantibodies to recombinant human CTL2 in autoimmune hearing loss by Kommareddi, Pavan K., Nair, Thankam S., Vallurupalli, Mounica, Telian, Steven A., Alexander Arts, H., El-Kashlan, Hussam K., Sataloff, Robert T., Carey, Thomas E.

“…Objectives/Hypothesis: Choline transporter‐like protein 2 (CTL2), a 68–72 kDa inner‐ear membrane glycoprotein, is a candidate target antigen in autoimmune…”
Get full text

Identification and Characterization of Choline Transporter-Like Protein 2, an Inner Ear Glycoprotein of 68 and 72 kDa That Is the Target of Antibody-Induced Hearing Loss by Nair, Thankam S, Kozma, Kelley E, Hoefling, Nickoleta L, Kommareddi, Pavan K, Ueda, Yo, Gong, Tzy-Wen, Lomax, Margaret I, Lansford, Christopher D, Telian, Steven A, Satar, Bulent, Arts, H. Alexander, El-Kashlan, Hussam K, Berryhill, Wayne E, Raphael, Yehoash, Carey, Thomas E

“…The Kresge Hearing Research Institute-3 (KHRI-3) antibody binds to a guinea pig inner ear supporting cell antigen (IESCA) and causes hearing loss. To gain…”
Get full text

Corticosteroid Response and Supporting Cell Antibody in Autoimmune Hearing Loss by Zeitoun, Hisham, Beckman, Jennifer Gray, Arts, H. Alexander, Lansford, Christopher D, Lee, David S, El-Kashlan, Hussam K, Telian, Steven A, Denny, Dawn E, Ramakrishnan, Anna, Nair, Thankam S, Disher, Michael J, Sataloff, Robert T, Fisher, Susan G, Carey, Thomas E

“…OBJECTIVE To determine whether antibodies to supporting cells are associated with response to corticosteroids in patients with autoimmune sensorineural hearing…”
Get full text

KHRI-3 monoclonal antibody-induced damage to the inner ear: antibody staining of nascent scars by Nair, Thankam S, Prieskorn, Diane M, Miller, Josef M, Dolan, David F, Raphael, Yehoash, Carey, Thomas E

“…Intracochlear infusion of the KHRI-3 monoclonal antibody results in in vivo binding to guinea pig inner ear supporting cells, loss of hair cells and hearing…”
Get full text

In vivo binding and hearing loss after intracochlear infusion of KHRI-3 antibody by Nair, Thankam S, Prieskorn, Diane M, Miller, Josef M, Mori, Atsuko, Gray, Jennifer, Carey, Thomas E

“…The IgG1 mouse monoclonal antibody (MAb) KHRI-3, binds to an antigen of 65–68 kDa expressed on inner ear supporting cells in guinea pigs. We previously showed…”
Get full text

Abstract 2720: Cidofovir modulates HPV E6 and E7 as well as p53, Rb and MDM2 in HPV16 naturally transformed head and neck squamous cell carcinoma and enhances chemosensitivity to Cisplatin by Park, Jung Je, Kommareddi, Pavan K, Nair, Thankam S., Seo, Ji Hyun, Jeon, Sea-Yuong, Kim, Sang Yoon, Prince, Mark E., Bradford, Carol R., Carey, Thomas E.

“…Purpose: The increasing incidence of oropharyngeal head and neck squamous cell carcinoma (HNSCC) is largely associated with sexually transmitted infection with…”
Get full text

Age-related changes in expression of CTL2/SLC44 by Beyer, Lisa A, Galano, Maria M, Nair, Thankam S, Kommareddi, Pavan K, Sha, Su-Hua, Raphael, Yehoash, Carey, Thomas E, Chen, Zhangli, Hu, Guangshu, Glasberg, Brian R, Moore, Brian CJ

“…The membrane glycoprotein CTL2/SLC44T2: Hearing Research A model for calculating auditory excitation patterns and loudness for steady sounds for normal hearing…”
Get full text

Human Autoantibodies and Monoclonal Antibody KHRI-3 Bind to a Phylogenetically Conserved Inner-ear-supporting Cell Antigen by DISHER, MICHAEL J., RAMAKRISHNAN, ANNA, NAIR, THANKAM S., MILLER, JOSEF M., TELIAN, STEVEN A., ARTS, H. ALEXANDER, SATALOFF, ROBERT T., ALTSCHULER, RICHARD A., RAPHAEL, YEHOASH, CAREY, THOMAS E.

“…Autoimmunity is thought to be one cause of sensorineural hearing loss (SNHL). Sera from patients with rapidly progressive hearing loss have been shown to…”
Get full text

β4 integrin transfection of UM-UC-2 (human bladder carcinoma) cells : Stable expression of a spontaneous cytoplasmic truncation mutant with rapid loss of clones expressing intact β4 by SANG YOON KIM, BACHMAN, N. J, NAIR, T. S, GOLDSMITH, S, LIEBERT, M, GROSSMAN, H. B, LOMAX, M. I, CAREY, T. E

Get full text

Human Autoantibodies and Monoclonal Antibody KHRI‐3 Bind to a Phylogenetically Conserved Inner‐ear‐supporting Cell Antigena by DISHER, MICHAEL J., RAMAKRISHNAN, ANNA, NAIR, THANKAM S., MILLER, JOSEF M., TELIAN, STEVEN A., ARTS, H. ALEXANDER, SATALOFF, ROBERT T., ALTSCHULER, RICHARD A., RAPHAEL, YEHOASH, CAREY, THOMAS E.

Get full text

Monoclonal antibody induced hearing loss by Nair, Thankam S., Raphael, Yehoash, Dolan, David F., Parrett, Timothy J., Perlman, Larry S., Brahmbhatt, Vivek R., Wang, Yu, Hou, Xiaoming, Ganjei, Gholizadeh, Nuttall, Alfred L., Altschuler, Richard A., Carey, Thomas E.

“…Monoclonal antibodies KHRI-3 and KHRI-5 identify antigens expressed on inner ear supporting cells and auditory hair cells respectively. To determine if these…”
Get full text

Monoclonal antibodies to inner ear antigens: I. Antigens expressed by supporting cells of the guinea pig cochlea by Zajic, G, Nair, T S, Ptok, M, Van Waes, C, Altschuler, R A, Schacht, J, Carey, T E

“…Murine monoclonal antibodies against guinea pig cochlear epithelium were generated with the goal of identifying cochlea-specific antigens and elucidating their…”
Get more information

Monoclonal antibodies to inner ear antigens: II. Antigens expressed in sensory cell stereocilia by Ptok, M, Nair, T S, Altschuler, R A, Schacht, J, Carey, T E

“…To develop biological reagents for investigating structure-function relationships in the organ of Corti, we have raised monoclonal antibodies, (MAb) to inner…”
Get more information