Search Results - "NAINA VINAY MUDUGAL"
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An IPTG Inducible Conditional Expression System for Mycobacteria
Published in PloS one (06-08-2015)“…Conditional expression strains serve as a valuable tool to study the essentiality and to establish the vulnerability of a target under investigation in a drug…”
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Assessment of Mycobacterium tuberculosis Pantothenate Kinase Vulnerability through Target Knockdown and Mechanistically Diverse Inhibitors
Published in Antimicrobial agents and chemotherapy (01-06-2014)“…Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenate, the first committed and rate-limiting step toward coenzyme A (CoA) biosynthesis. In…”
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Pyrazolopyrimidines Establish MurC as a Vulnerable Target in Pseudomonas aeruginosa and Escherichia coli
Published in ACS chemical biology (17-10-2014)“…The bacterial peptidoglycan biosynthesis pathway provides multiple targets for antibacterials, as proven by the clinical success of β-lactam and glycopeptide…”
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Genetic and chemical validation identifies Mycobacterium tuberculosis topoisomerase I as an attractive anti-tubercular target
Published in Tuberculosis (Edinburgh, Scotland) (01-09-2015)“…Summary DNA topoisomerases perform the essential function of maintaining DNA topology in prokaryotes. DNA gyrase, an essential enzyme that introduces negative…”
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An IPTG Inducible Conditional Expression System for Mycobacteria: e0134562
Published in PloS one (01-08-2015)“…Conditional expression strains serve as a valuable tool to study the essentiality and to establish the vulnerability of a target under investigation in a drug…”
Get full text
Journal Article