Search Results - "NAGATSUKA, S"

Progressive loss of cortical acetylcholinesterase activity in association with cognitive decline in Alzheimer's disease: A positron emission tomography study by Shinotoh, Hitoshi, Namba, Hiroki, Fukushi, Kiyoshi, Nagatsuka, Shin-Ichiro, Tanaka, Noriko, Aotsuka, Akiyo, Ota, Tsuneyoshi, Tanada, Shuji, Irie, Toshiaki

“…We measured brain acetylcholinesterase activity in 30 patients with Alzheimer's disease (AD) and 14 age‐matched controls by positron emission tomography (PET)…”
Get full text

Effect of donepezil on brain acetylcholinesterase activity in patients with AD measured by PET by SHINOTOH, H, AOTSUKA, A, FUKUSHI, K, NAGATSUKA, S, TANAKA, N, OTA, T, TANADA, S, IRIE, T

“…Acetylcholinesterase (AChE) activities in the brain of three patients with AD were measured once before and once during donepezil treatment (5 mg/d in two…”
Get full text

Positron emission tomographic measurement of acetylcholinesterase activity reveals differential loss of ascending cholinergic systems in Parkinson's disease and progressive supranuclear palsy by Shinotoh, Hitoshi, Namba, Hiroki, Yamaguchi, Mika, Fukushi, Kiyoshi, Nagatsuka, Shin-Ichiro, Iyo, Masaomi, Asahina, Masto, Hattori, Takamichi, Tanada, Shuzi, Irie, Toshiaki

“…We measured brain acetylcholinesterase activity in 16 patients with Parkinson's disease (PD), 12 patients with progressive supranuclear palsy (PSP), and 13…”
Get full text

Observation of electromagnetically induced transparency for a squeezed vacuum with the time domain method by Arikawa, M, Honda, K, Akamatsu, D, Yokoil, Y, Akiba, K, Nagatsuka, S, Furusawa, A, Kozuma, M

“…A probe light in a squeezed vacuum state was injected into cold 87Rb atoms with an intense control light in a coherent state. A sub-MHz window was created due…”
Get full text

Acetylcholinesterase imaging: its use in therapy evaluation and drug design by Shinotoh, Hitoshi, Fukushi, Kiyoshi, Nagatsuka, Shin-ichiro, Irie, Toshiaki

“…Several cholinesterase (ChE) inhibitors have been labeled with carbon-11 for visualizing binding sites on acetylcholinesterase (AChE) by positron emission…”
Get more information

The amygdala and Alzheimer's disease: positron emission tomographic study of the cholinergic system by Shinotoh, H, Fukushi, K, Nagatsuka, S, Tanaka, N, Aotsuka, A, Ota, T, Namba, H, Tanada, S, Irie, T

“…The primary transmitter deficit is cholinergic in Alzheimer's disease (AD), and the amygdala receives a major cholinergic projection from the nucleus basalis…”
Get full text

Human cerebral acetylcholinesterase activity measured with positron emission tomography: procedure, normal values and effect of age by Namba, H, Iyo, M, Fukushi, K, Shinotoh, H, Nagatsuka, S, Suhara, T, Sudo, Y, Suzuki, K, Irie, T

“…The regional cerebral metabolic rate of [11C]N-methyl-4-piperidyl acetate, which is nearly proportional to regional cerebral acetylcholinesterase (AChE)…”
Get full text

Brain Acetylcholinesterase Activity: Validation of a PET Tracer in a Rat Model of Alzheimer's Disease by Irie, Toshiaki, Fukushi, Kiyoshi, Namba, Hiroki, Iyo, Masaomi, Tamagami, Hiroshi, Nagatsuka, Shin-ichiro, Ikota, Nobuo

“…We developed three radioactive acetylcholine analogs--N[14C]methyl-4-piperidyl acetate ([14C]MP4A), propionate ([14C]MP4P) and isobutyrate ([14C]MP4IB)--as…”
Get full text

Brain acetylcholinesterase activity in Alzheimer disease measured by positron emission tomography by SHINOTOH, H, NAMBA, H, FUKUSHI, K, NAGATSUKA, S.-I, TANAKA, N, AOTSUKA, A, TANADA, S, IRIE, T

“…Brain acetylcholinesterase activity was measured in 14 patients with Alzheimer disease and 14 age-matched control subjects by positron emission tomography with…”
Get full text

Transcriptome analysis of human liver in chimeric PXB-Mouse® for risk marker identification associated with drug-induced liver injury by Enomoto, H., Tachiki, H., Shimada, T., Nagatsuka, S., Nakashima, M.

Get full text

Kinetic Analysis of [ C]MP4A Using a High-Radioactivity Brain Region That Represents an Integrated Input Function for Measurement of Cerebral Acetylcholinesterase Activity Without Arterial Blood Sampling by Nagatsuka, Shin-Ichiro, Fukushi, Kiyoshi, Shinotoh, Hitoshi, Namba, Hiroki, Iyo, Masaomi, Tanaka, Noriko, Aotsuka, Akiyo, Ota, Tsuneyoshi, Tanada, Shuji, Irie, Toshiaki

“…N-[11C]methylpiperidin-4-yl acetate ([11C]MP4A) is an acetylcholine analog. It has been used successfully for the quantitative measurement of…”
Get full text

Identification of microRNA as possible risk marker for drug-induced liver injury using chimeric PXB-Mouse® with highly humanized liver by Kitahara, T., Shimada, T., Nagatsuka, S., Enomoto, H., Tachiki, H., Sasaki, H.

Get full text

Nonvolatile Memory With Extremely Low-Leakage Indium-Gallium-Zinc-Oxide Thin-Film Transistor by Inoue, H., Matsuzaki, T., Nagatsuka, S., Okazaki, Y., Sasaki, T., Noda, K., Matsubayashi, D., Ishizu, T., Onuki, T., Isobe, A., Shionoiri, Y., Kato, K., Okuda, T., Koyama, J., Yamazaki, S.

“…Emerging nonvolatile memory with an oxide-semiconductor-based thin-film transistor (TFT) using indium-gallium-zinc-oxide (IGZO) was developed. The memory is…”
Get full text

Identification of possible biomarker genes for drug-induced liver injury using chimeric PXB-mouse® with highly humanized liver by Enomoto, H., Tachiki, H., Shimada, T., Nagatsuka, S.-I., Nakashima, M.

Get full text

Precision of Kinetic Parameters in Irreversibly Trapped Radiotracers by Nagatsuka, S., Fukushi, K., Namba, H., Iyo, M., Shinotoh, H., Tanada, S., Irie, T.

“…In radiotracers of metabolic trapping or irreversible binding type, reliable range of estimated parameter representing such process is quite limited…”
Get full text

Brain Acetylcholinesterase Activity in Progressive Supranuclear Palsy and Parkinson's Disease by Shinotoh, H., Yamaguchi, M., Namba, H., Fukushi, K., Nagatsuka, S., Hattori, T., Tanada, S., Irie, T.

“…Dysfunction of brain cholinergic system has been demonstrated in autopsied brains of progressive supranuclear palsy (PSP) and Parkinson's disease (PD). We have…”
Get full text

In vivo mapping of brain cholinergic function in Parkinson's disease and progressive supranuclear palsy by Shinotoh, H, Namba, H, Yamaguchi, M, Fukushi, K, Nagatsuka, S, Iyo, M, Asahina, M, Hattori, T, Tanada, S, Irie, T

Get more information

Preserved acetylcholinesterase activity in aged cerebral cortex by Namba, Hiroki, lyo, Masaomi, Shinotoh, Hitoshi, Nagatsuka, Sin-ichiro, Fukushi, Kiyoshi, Irie, Toshiaki

Get full text

Expression of Neurokinin B Receptor in the Gingival Squamous Cell Carcinoma Bone Microenvironment by Yoshida, Shoko, Shimo, Tsuyoshi, Takabatake, Kiyofumi, Murase, Yurika, Obata, Kyoichi, Okui, Tatsuo, Kunisada, Yuki, Ibaragi, Soichiro, Nagatsuka, Hitoshi, Sasaki, Akira

“…Gingival squamous cell carcinoma (SCC) frequently invades the maxillary or mandibular bone, and bone destruction is known as a key prognostic factor in…”
Get full text

Measurement of acetylcholinesterase by positron emission tomography in the brains of healthy controls and patients with Alzheimer's disease by Iyo, M, Namba, H, Fukushi, K, Shinotoh, H, Nagatsuka, S, Suhara, T, Sudo, Y, Suzuki, K, Irie, T

“…Acetylcholinesterase activity, a marker for degeneration of the central cholinergic system, has consistently been reported, in necropsy brain studies, to be…”
Get more information