Search Results - "NAGATSU, YOSHIO"

Biomimetic Oxidation of 2-Methylimidazole Derivative with a Chemical Model System for Cytochrome P-450 by Miyachi, Hiroyuki, Nagatsu, Yoshio

“…A chemical model system for cytochrome P-450, consisting of tetraphenylporphyrin manganese chloride (TPPMnCl) and iodosylbenzene, efficiently oxidized…”
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Synthesis of Metabolites and Related Compounds of 3-Isobutyryl-2-isopropylpyrazolo[1, 5-α]pyridine (Ibudilast). II. Metabolites of Pyridine Ring by AWANO, Katsuya, IWASE, Kazuhiko, NAGATSU, Yoshio, SUZUE, Seigo

“…Novel 6-hydroxylated or methanesulfonylated pyrazolo[1, 5-α]pyridine derivatives as an authentic reference of metabolites for…”
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Facile prepartion of unstable metabolic intermediates; Epoxide(s) of pyrazolo[1,5-a]pyridine derivatives by the cytochrome P-450 chemical model by NAGATSU, Yoshio, HIGUCHI, Tsunehiko, HIROBE, Masaaki

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METABOLISM OF FLEROXACIN IN HUMANS AND VARIOUS EXPERIMENTAL ANIMALS by KAWAHARA, FUMIO, OOIE, TSUYOSHI, NAGATSU, YOSHIO, UCHIDA, HIROSHI

“…Metabolites of fleroxacin in urine of dogs and rabbits wereisolated and identified using TLC, UV, HPLC, NMR and mass spectrometry. Fleroxacin and its major…”
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ABSORPTION, DISTRIBUTION AND EXCRETION OF 14C-FLEROXACIN IN RATS AND RABBITS by NAGATSU, YOSHIO, MUKAI, MASAAKI, TAKAGI, KOICHI, UCHIDA, HIROSHI

“…We studied the biological disposition and fate of fleroxacin in rats and rabbits using 14C-labeled fleroxacin. Fleroxacin was absorbed from the small intestine…”
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STUDIES ON THE METABOLISM OF 14C-LABELLED AM-715 by NAGATSU, YOSHIO, ENDO, KYOHEI, IRIKURA, TSUTOMU

“…The metabolism of l-ethyl-6-fluoro-1, 4-dihydro-4-oxo-7-(1-piperaziny1)-3-quinolinecarboxylic acid (AM-715) was studied in rats, a dog and monkeys following an…”
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STUDIES ON THE FATE OF 14C-LABELLED AM-715 by NAGATSU, YOSHIO, ENDO, KYOHEI, IRIKURA, TSUTOMU

“…Absorption, distribution and excretion of 1-ethyl-6-fluoro-1, 4-dihydro-4-oxo-7-(1-piperaz1ny1)-3-quinolinecarboxylic acid (AM-715) were studied in rats, mice,…”
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鎮痛剤に関する研究(第14報)1-n-Butyryl-4-cinnamyl[γ-14C]piperazine Hydrochloride(BCP-14C)のラットにおける吸収, 排泄, 体内分布および代謝について by 入倉, 勉, 永津, 芳雄, 馬場, 茂雄, 曾根, 久雄

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Application of Chemical P-450 Model Systems to Study Drug Metabolism. III by NAGATSU, Yoshio, HIGUCHI, Tsunehiko, HIROBE, Masaaki

“…Oxidation of 3-isobutyryl-2-isopropylpyrazolo[1, 5-α]pyridine (IBPP) was carried out with various chemical model systems for cytochrome P-450 in comparison…”
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同位体による薬物代謝の研究(第18報)イオンクラスター法による1-Butyryl-4-cinnamylpiperazineの尿中代謝産物の検索 by 馬場, 茂雄, 森下, 信一, 永津, 芳雄

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Application of Chemical P-450 Model Systems to Study Drug Metabolism. III. : Metabolism of 3-Isobutyryl-2-isopropylpyrazolo[1, 5-α]pyridine by NAGATSU, Yoshio, HIGUCHI, Tsunehiko, HIROBE, Masaaki

“…Oxidation of 3-isobutyryl-2-isopropylpyrazolo[1, 5-α]pyridine (IBPP) was carried out with various chemical model systems for cytochrome P-450 in comparison…”
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FACILE PREPARATION OF UNSTABLE METABOLIC INTERMEDIATES : EPOXIDE(S) OF PYRAZOLO[1, 5-a]PYRIDINE DERIVATIVES BY THE CYTOCHROME P-450 CHEMICAL MODEL by NAGATSU, Yoshio, HIGUCHI, Tsunehiko, HIROBE, Masaaki

“…Biomimetic oxidation of bioactive pyrazolo[1, 5-a]pyridine derivatives carried out with the chemical model for cytochrome P-450, afforded 6, 7-epoxides in…”
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Studies on Drug Metabolism by Use of Isotopes. XVIII.1) Ion Cluster Technique for Detection of Urinary Metabolites of 1-Butyryl-4-cinnamylpiperazine by BABA, SHIGEO, MORISITA, SHIN-ICHI, NAGATSU, YOSHIO

“…The structural elucidation of several unidentified metabolites of 1-butyryl-4-cin-namylpiperazine (I) in mice and guinea pigs was made by the ion cluster…”
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Studies on Analgesic Drugs. XIV. Absorption, Excretion, Distribution and Metabolism of 1-n-Butyryl-4-cinnamyl [γ-14C] piperazine Hydrochloride (BCP-14C) in the Rat by IRIKURA, TSUTOMU, NAGATSU, YOSHIO, BABA, SHIGEO, SONE, HISAO

“…In order to study the metabolic fate of 1-butyryl-4-cinnamylpiperazine hydrochloride (BCP), a new analgesic drug, 1-butyryl-4-cinnamyl [γ-14C] piperazine…”
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