Search Results - "NAGASE, Hiroki"

Obesity reduces the anticancer effect of AdipoRon against orthotopic pancreatic cancer in diet-induced obese mice by Takenaga, Keizo, Akimoto, Miho, Koshikawa, Nobuko, Nagase, Hiroki

“…The antidiabetic adiponectin receptor agonist AdipoRon has been shown to suppress the tumour growth of human pancreatic cancer cells. Because obesity and…”
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Concise synthesis of cyclic carbonyl compounds from haloarenes using phenyl formate as the carbonyl source by Konishi, Hideyuki, Nagase, Hiroki, Manabe, Kei

“…Various cyclic carbonyl compounds were concisely synthesized by carbonylative cyclization of haloarenes bearing nucleophilic moieties under Pd catalysis. A…”
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Radiogenomics for predicting p53 status, PD-L1 expression, and prognosis with machine learning in pancreatic cancer by Iwatate, Yosuke, Hoshino, Isamu, Yokota, Hajime, Ishige, Fumitaka, Itami, Makiko, Mori, Yasukuni, Chiba, Satoshi, Arimitsu, Hidehito, Yanagibashi, Hiroo, Nagase, Hiroki, Takayama, Wataru

“…Background Radiogenomics is an emerging field that integrates “Radiomics” and “Genomics”. In the current study, we aimed to predict the genetic information of…”
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MCT4 is induced by metastasis-enhancing pathogenic mitochondrial NADH dehydrogenase gene mutations and can be a therapeutic target by Takenaga, Keizo, Koshikawa, Nobuko, Akimoto, Miho, Tatsumi, Yasutoshi, Lin, Jason, Itami, Makiko, Nagase, Hiroki

“…Pathogenic mitochondrial NADH dehydrogenase ( ND ) gene mutations enhance the invasion and metastasis of various cancer cells, and they are associated with…”
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MIR1246 in body fluids as a biomarker for pancreatic cancer by Ishige, Fumitaka, Hoshino, Isamu, Iwatate, Yosuke, Chiba, Satoshi, Arimitsu, Hidehito, Yanagibashi, Hiroo, Nagase, Hiroki, Takayama, Wataru

“…Pancreatic cancer is an aggressive tumor associated with poor survival, and early detection is important to improve patient outcomes. In the present study, we…”
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Suppression of non‐small‐cell lung cancer A549 tumor growth by an mtDNA mutation‐targeting pyrrole‐imidazole polyamide‐triphenylphosphonium and a senolytic drug by Tsuji, Kohei, Kida, Yuki, Koshikawa, Nobuko, Yamamoto, Seigi, Shinozaki, Yoshinao, Watanabe, Takayoshi, Lin, Jason, Nagase, Hiroki, Takenaga, Keizo

“…Certain somatic mutations in mtDNA were associated with tumor progression and frequently found in a homoplasmic state. We recently reported that…”
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Mitochondria: Endosymbiont bacteria DNA sequence as a target against cancer by Nagase, Hiroki, Watanabe, Takayoshi, Koshikawa, Nobuko, Yamamoto, Seigi, Takenaga, Keizo, Lin, Jason

“…As the energy factory for the cell, the mitochondrion, through its role of adenosine triphosphate production by oxidative phosphorylation, can be regarded as…”
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Cancer cell-derived interleukin-33 decoy receptor sST2 enhances orthotopic tumor growth in a murine pancreatic cancer model by Takenaga, Keizo, Akimoto, Miho, Koshikawa, Nobuko, Nagase, Hiroki

“…Proinflammatory interleukin-33 (IL-33) binds to its receptor ST2L and is involved in inflammation and the malignant behavior of cancer cells. However, the role…”
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Identification of novel mutations in Japanese ovarian clear cell carcinoma patients using optimized targeted NGS for clinical diagnosis by Maru, Yoshiaki, Tanaka, Naotake, Ohira, Miki, Itami, Makiko, Hippo, Yoshitaka, Nagase, Hiroki

“…Abstract Objective Ovarian clear cell carcinoma (OCCC) is an aggressive ovarian cancer with a higher frequency in Japan and often becomes chemorefractory…”
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Intercellular transfer of mitochondrial DNA carrying metastasis-enhancing pathogenic mutations from high- to low-metastatic tumor cells and stromal cells via extracellular vesicles by Takenaga, Keizo, Koshikawa, Nobuko, Nagase, Hiroki

“…Mitochondrial DNA (mtDNA) carrying certain pathogenic mutations or single nucleotide variants (SNVs) enhances the invasion and metastasis of tumor cells, and…”
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Targeting the mutant PIK3CA gene by DNA‐alkylating pyrrole‐imidazole polyamide in cervical cancer by Krishnamurthy, Sakthisri, Yoda, Hiroyuki, Hiraoka, Kiriko, Inoue, Takahiro, Lin, Jason, Shinozaki, Yoshinao, Watanabe, Takayoshi, Koshikawa, Nobuko, Takatori, Atsushi, Nagase, Hiroki

“…PIK3CA is the most frequently mutated oncogene in cervical cancer, and somatic mutations in the PIK3CA gene result in increased activity of PI3K. In cervical…”
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Radiogenomics predicts the expression of microRNA-1246 in the serum of esophageal cancer patients by Hoshino, Isamu, Yokota, Hajime, Ishige, Fumitaka, Iwatate, Yosuke, Takeshita, Nobuyoshi, Nagase, Hiroki, Uno, Takashi, Matsubara, Hisahiro

“…Radiogenomics is a new field that provides clinically useful prognostic predictions by linking molecular characteristics such as the genetic aberrations of…”
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Prediction of the differences in tumor mutation burden between primary and metastatic lesions by radiogenomics by Hoshino, Isamu, Yokota, Hajime, Iwatate, Yosuke, Mori, Yasukuni, Kuwayama, Naoki, Ishige, Fumitaka, Itami, Makiko, Uno, Takashi, Nakamura, Yuki, Tatsumi, Yasutoshi, Shimozato, Osamu, Nagase, Hiroki

“…Tumor mutational burden (TMB) is gaining attention as a biomarker for responses to immune checkpoint inhibitors in cancer patients. In this study, we evaluated…”
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Targeting anaplastic lymphoma kinase (ALK) gene alterations in neuroblastoma by using alkylating pyrrole-imidazole polyamides by Ota, Yoko, Yoda, Hiroyuki, Inoue, Takahiro, Watanabe, Takayoshi, Shinozaki, Yoshinao, Takatori, Atsushi, Nagase, Hiroki

“…Anaplastic lymphoma kinase ( ALK ) aberration is related to high-risk neuroblastomas and is an important therapeutic target. As acquired resistance to ALK…”
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Direct Targeting of MYCN Gene Amplification by Site-Specific DNA Alkylation in Neuroblastoma by Yoda, Hiroyuki, Inoue, Takahiro, Shinozaki, Yoshinao, Lin, Jason, Watanabe, Takayoshi, Koshikawa, Nobuko, Takatori, Atsushi, Nagase, Hiroki

“…Amplification of plays a pivotal role in multiple types of tumors and correlates with poor prognosis in high-risk neuroblastoma. Despite recent advances in the…”
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Acute and chronic effects of exercise on mRNA expression in the skeletal muscle of two mouse models of peripheral artery disease by Nagase, Hiroki, Yao, Shuhei, Ikeda, Shota

“…Endurance exercise improves walking performance in patients with peripheral artery disease (PAD), which is characterized by skeletal muscle dysfunction caused…”
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FGFR2 loss sensitizes MYCN‐amplified neuroblastoma CHP134 cells to CHK1 inhibitor–induced apoptosis by Ando, Kiyohiro, Ohira, Miki, Takada, Ichiro, Cázares‐Ordoñez, Verna, Suenaga, Yusuke, Nagase, Hiroki, Kobayashi, Shinichi, Koshinaga, Tsugumichi, Kamijo, Takehiko, Makishima, Makoto, Wada, Satoshi

“…Checkpoint kinase 1 (CHK1) plays a key role in genome surveillance and integrity throughout the cell cycle. Selective inhibitors of CHK1 (CHK1i) are undergoing…”
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The Road Not Taken with Pyrrole-Imidazole Polyamides: Off-Target Effects and Genomic Binding by Lin, Jason, Nagase, Hiroki

“…The high sequence specificity of minor groove-binding -methylpyrrole- -methylimidazole polyamides have made significant advances in cancer and disease biology,…”
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Anticancer effect of a pyrrole‐imidazole polyamide‐triphenylphosphonium conjugate selectively targeting a common mitochondrial DNA cancer risk variant in cervical cancer cells by Yao, Jihang, Takenaga, Keizo, Koshikawa, Nobuko, Kida, Yuki, Lin, Jason, Watanabe, Takayoshi, Maru, Yoshiaki, Hippo, Yoshitaka, Yamamoto, Seigi, Zhu, Yuyan, Nagase, Hiroki

“…Cervical cancer remains a major threat to women's health, especially in countries with limited medical resources, and new drugs are needed to improve patient…”
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Matters of data openness and KapWeb, a web tool of multi‐cancer survival analysis for cancer survivors by Lin, Jason, Nakamura, Yohko, Mikami, Haruo, Kusakabe, Miho, Saruki, Nobuhiro, Wakao, Fumihiko, Nagase, Hiroki

“…KapWeb is an interactive tool for the determination of cancer survival rates based on case outcomes compiled from more than half a million records from cancer…”
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