Search Results - "NAGARATHNAM, D"

Cytotoxicities of Some Flavonoid Analogues by Cushman, Mark, Nagarathnam, Dhanapalan

“…An array of 55 flavones having a variety of substituents was evaluated for cytotoxicity in five cancer cell cultures: A-549 lung carcinoma, MCF-7 breast…”
Get full text

GABA(B) receptors function as a heteromeric assembly of the subunits GABA(B)R1 and GABA(B)R2 by Jones, K A, Borowsky, B, Tamm, J A, Craig, D A, Durkin, M M, Dai, M, Yao, W J, Johnson, M, Gunwaldsen, C, Huang, L Y, Tang, C, Shen, Q, Salon, J A, Morse, K, Laz, T, Smith, K E, Nagarathnam, D, Noble, S A, Branchek, T A, Gerald, C

“…The principal inhibitory neurotransmitter GABA (gamma-aminobutyric acid) exerts its effects through two ligand-gated channels, GABA(A) and GABA(C) receptors,…”
Get full text

In vitro and in vivo evaluation of dihydropyrimidinone C-5 amides as potent and selective alpha(1A) receptor antagonists for the treatment of benign prostatic hyperplasia by Barrow, J C, Nantermet, P G, Selnick, H G, Glass, K L, Rittle, K E, Gilbert, K F, Steele, T G, Homnick, C F, Freidinger, R M, Ransom, R W, Kling, P, Reiss, D, Broten, T P, Schorn, T W, Chang, R S, O'Malley, S S, Olah, T V, Ellis, J D, Barrish, A, Kassahun, K, Leppert, P, Nagarathnam, D, Forray, C

“…alpha(1) Adrenergic receptors mediate both vascular and lower urinary tract tone, and alpha(1) receptor antagonists such as terazosin (1b) are used to treat…”
Get full text

Design and synthesis of novel alpha(1)(a) adrenoceptor-selective antagonists. 1. Structure-activity relationship in dihydropyrimidinones by Nagarathnam, D, Miao, S W, Lagu, B, Chiu, G, Fang, J, Murali Dhar, T G, Zhang, J, Tyagarajan, S, Marzabadi, M R, Zhang, F, Wong, W C, Sun, W, Tian, D, Wetzel, J M, Forray, C, Chang, R S, Broten, T P, Ransom, R W, Schorn, T W, Chen, T B, O'Malley, S, Kling, P, Schneck, K, Bendesky, R, Harrell, C M

“…Dihydropyrimidinones such as compound 12 exhibited high binding affinity and subtype selectivity for the cloned human alpha(1a) receptor. Systematic…”
Get full text

Synthesis and evaluation of stilbene and dihydrostilbene derivatives as potential anticancer agents that inhibit tubulin polymerization by Cushman, Mark, Nagarathnam, Dhanapalan, Gopal, D, Chakraborti, Asit K, Lin, Chii M, Hamel, Ernest

“…An array of cis-, trans-, and dihydrostilbenes and some N-arylbenzylamines were synthesized and evaluated for their cytotoxicity in the five cancer cell…”
Get full text

Synthesis and evaluation of analogs of (Z)-1-(4-methoxyphenyl)-2-(3,4,5-trimethoxyphenyl)ethene as potential cytotoxic and antimitotic agents by Cushman, Mark, Nagarathnam, Dhanapalan, Gopal, D, He, Hu Ming, Lin, Chii M, Hamel, Ernest

“…A series of stilbenes has been prepared and tested for cytotoxicity in the five human cancer cell lines A-549 non-small cell lung, MCF-7 breast, HT-29 colon,…”
Get full text

Substituted aminobenzimidazole pyrimidines as cyclin-dependent kinase inhibitors by Verma, Sharad, Nagarathnam, Dhanapalan, Shao, Jianxing, Zhang, Lei, Zhao, Jin, Wang, Yamin, Li, Tindy, Mull, Eric, Enyedy, Istvan, Wang, Chunguang, Zhu, Qingming, Altieri, Martha, Jordan, Jerold, Dang, Thu-Thi-Anh, Reddy, Sanjeeva

“…Substituted aminobenzimidazole pyrimidines were synthesized and are shown to display potent biochemical activity against CDK1. Docking studies carried out with…”
Get full text

Synthesis and protein-tyrosine kinase inhibitory activities of flavonoid analogs by Cushman, Mark, Nagarathnam, Dhanapalan, Burg, Debra L, Geahlen, Robert L

“…Treatment of o-hydroxyacetophenones 2a-e with excess lithium bis(trimethylsilyl)amide followed by dialkyl carbonates gave alkyl…”
Get full text

Design and synthesis of novel alpha(1)(a) adrenoceptor-selective antagonists. 2. Approaches to eliminate opioid agonist metabolites via modification of linker and 4-methoxycarbonyl-4-phenylpiperidine moiety by Murali Dhar, T G, Nagarathnam, D, Marzabadi, M R, Lagu, B, Wong, W C, Chiu, G, Tyagarajan, S, Miao, S W, Zhang, F, Sun, W, Tian, D, Shen, Q, Zhang, J, Wetzel, J M, Forray, C, Chang, R S, Broten, T P, Schorn, T W, Chen, T B, O'Malley, S, Ransom, R, Schneck, K, Bendesky, R, Harrell, C M, Vyas, K P

“…We have previously described compound 1a as a high-affinity subtype selective alpha(1a) antagonist. In vitro and in vivo evaluation of compound 1a showed its…”
Get full text

Design and synthesis of novel alpha(1)(a) adrenoceptor-selective antagonists. 3. Approaches to eliminate opioid agonist metabolites by using substituted phenylpiperazine side chains by Lagu, B, Tian, D, Nagarathnam, D, Marzabadi, M R, Wong, W C, Miao, S W, Zhang, F, Sun, W, Chiu, G, Fang, J, Forray, C, Chang, R S, Ransom, R W, Chen, T B, O'Malley, S, Zhang, K, Vyas, K P, Gluchowski, C

“…Dihydropyrimidinones, such as 1, represent a novel class of alpha(1a) adrenoceptor antagonists with potential for the treatment of benign prostatic hyperplasia…”
Get full text

A facile preparation of 2-(2-arylethyl)- and 2-(aminomethyl)indoles by Nagarathnam, Dhanapalan

“…An important process for the acid catalyzed cleavage of the benzoyl group from 3‐benzoylindoles in high yield is identified and its application for the facile…”
Get full text

Design and synthesis of novel alpha(1)(a) adrenoceptor-selective antagonists. 4. Structure-activity relationship in the dihydropyrimidine series by Wong, W C, Sun, W, Lagu, B, Tian, D, Marzabadi, M R, Zhang, F, Nagarathnam, D, Miao, S W, Wetzel, J M, Peng, J, Forray, C, Chang, R S, Chen, T B, Ransom, R, O'Malley, S, Broten, T P, Kling, P, Vyas, K P, Zhang, K, Gluchowski, C

“…We have previously disclosed dihydropyridines such as 1a,b as selective alpha(1a) antagonists as a potential treatment for benign prostatic hyperplasia (BPH)…”
Get full text

A facile synthesis of 3-substituted indoles by Nagarathnam, Dhanapalan

“…1‐Benzoyl‐3‐bromomethylindole (2a) or 1‐benzenesulfonyl‐3‐bromomethylindole (2b) reacts with C, N, O, and P‐containing nucleophiles to give potential…”
Get full text

A short and facile synthetic route to hydroxylated flavones. New syntheses of apigenin, tricin, and luteolin by Nagarathnam, Dhanapalan, Cushman, Mark

Get full text

Phenylacetamides as selective alpha-1A adrenergic receptor antagonists by Patane, M A, DiPardo, R M, Newton, R C, Price, R P, Broten, T P, Chang, R S, Ransom, R W, Di Salvo, J, Nagarathnam, D, Forray, C, Gluchowski, C, Bock, M G

“…A novel class of potent and selective alpha-1a receptor antagonists has been identified. The structures of these antagonists were derived from truncating the…”
Get full text

Phenylacetamides as selective α-1A adrenergic receptor antagonists by Patane, Michael A., DiPardo, Robert M., Newton, Randall C., Price, RoseAnn P., Broten, Theodore P., Chang, Raymond S.L., Ransom, Richard W., Di Salvo, Jerry, Nagarathnam, Dhanapalan, Forray, Carlos, Gluchowski, Charles, Bock, Mark G.

“…A novel class of potent and selective α-1a receptor antagonists has been identified. The structures of these antagonists were derived from truncating the…”
Get full text

Synthesis and evaluation of furo[3,4-d]pyrimidinones as selective α1a-Adrenergic receptor antagonists by LAGU, B, DAKE TIAN, KANYIN ZHANG, GLUCHOWSKI, C, CHIU, G, NAGARATHNAM, D, FANG, J, QUANRONG SHEN, FORRAY, C, RANSOM, R. W, CHANG, R. S. L, VYAS, K. P

Get full text

Design and Synthesis of Novel alpha sub(1a) Adrenoceptor-Selective Antagonists. 4. Structure-Activity Relationship in the Dihydropyrimidine Series by Wong, Wai C, Sun, Wanying, Lagu, B, Tian, D, Marzabadi, M R, Zhang, Fengqi, Nagarathnam, D, Miao, S W, Wetzel, J M, Peng, Jian, ray, C, Chang, RSL, Chen, T B, Ransom, R

“…We have previously disclosed dihydropyridines such as 1a,b as selective alpha sub(1a) antagonists as a potential treatment for benign prostatic hyperplasia…”
Get full text

In vitro studies on L-771,688 (SNAP 6383), a new potent and selective alpha1A-adrenoceptor antagonist by Chang, R S, Chen, T B, O'Malley, S S, Pettibone, D J, DiSalvo, J, Francis, B, Bock, M G, Freidinger, R, Nagarathnam, D, Miao, S W, Shen, Q, Lagu, B, Murali Dhar, T G, Tyagarajan, S, Marzabadi, M R, Wong, W C, Gluchowski, C, Forray, C

“…L-771,688 (SNAP 6383, methyl(4S)-4-(3, 4-difluorophenyl)-6-[(methyloxy)methyl]-2-oxo-3-[(¿3-[4-(2-pyridin yl)-1-piperidinyl]propyl¿amino)carbonyl]-1,2,3,…”
Get full text

De novo design of a novel oxazolidinone analogue as a potent and selective alpha1A adrenergic receptor antagonist with high oral bioavailability by Lagu, B, Tian, D, Jeon, Y, Li, C, Wetzel, J M, Nagarathnam, D, Shen, Q, Forray, C, Chang, R S, Broten, T P, Ransom, R W, Chan, T B, O'Malley, S S, Schorn, T W, Rodrigues, A D, Kassahun, K, Pettibone, D J, Freidinger, R O, Gluchowski, C

Get full text