Search Results - "NAGARAJAN, Rakesh"

College of American Pathologists' laboratory standards for next-generation sequencing clinical tests by Aziz, Nazneen, Zhao, Qin, Bry, Lynn, Driscoll, Denise K, Funke, Birgit, Gibson, Jane S, Grody, Wayne W, Hegde, Madhuri R, Hoeltge, Gerald A, Leonard, Debra G B, Merker, Jason D, Nagarajan, Rakesh, Palicki, Linda A, Robetorye, Ryan S, Schrijver, Iris, Weck, Karen E, Voelkerding, Karl V

“…The higher throughput and lower per-base cost of next-generation sequencing (NGS) as compared to Sanger sequencing has led to its rapid adoption in clinical…”
Get full text

Identification of Medically Actionable Secondary Findings in the 1000 Genomes by Olfson, Emily, Cottrell, Catherine E, Davidson, Nicholas O, Gurnett, Christina A, Heusel, Jonathan W, Stitziel, Nathan O, Chen, Li-Shiun, Hartz, Sarah, Nagarajan, Rakesh, Saccone, Nancy L, Bierut, Laura J

“…The American College of Medical Genetics and Genomics (ACMG) recommends that clinical sequencing laboratories return secondary findings in 56 genes associated…”
Get full text

Proficiency Testing of Standardized Samples Shows Very High Interlaboratory Agreement for Clinical Next-Generation Sequencing-Based Oncology Assays by Merker, Jason D, Devereaux, Kelly, Iafrate, A John, Kamel-Reid, Suzanne, Kim, Annette S, Moncur, Joel T, Montgomery, Stephen B, Nagarajan, Rakesh, Portier, Bryce P, Routbort, Mark J, Smail, Craig, Surrey, Lea F, Vasalos, Patricia, Lazar, Alexander J, Lindeman, Neal I

“…Next-generation sequencing-based assays are being increasingly used in the clinical setting for the detection of somatic variants in solid tumors, but limited…”
Get full text

Adaptation of Myocardial Substrate Metabolism to a Ketogenic Nutrient Environment by Wentz, Anna E., d’Avignon, D. André, Weber, Mary L., Cotter, David G., Doherty, Jason M., Kerns, Robnet, Nagarajan, Rakesh, Reddy, Naveen, Sambandam, Nandakumar, Crawford, Peter A.

“…Heart muscle is metabolically versatile, converting energy stored in fatty acids, glucose, lactate, amino acids, and ketone bodies. Here, we use mouse models…”
Get full text

High throughput digital quantification of mRNA abundance in primary human acute myeloid leukemia samples by Payton, Jacqueline E, Grieselhuber, Nicole R, Chang, Li-Wei, Murakami, Mark, Geiss, Gary K, Link, Daniel C, Nagarajan, Rakesh, Watson, Mark A, Ley, Timothy J

“…Acute promyelocytic leukemia (APL) is characterized by the t(15;17) chromosomal translocation, which results in fusion of the retinoic acid receptor alpha…”
Get full text

Next-generation sequencing identifies the natural killer cell microRNA transcriptome by Fehniger, Todd A, Wylie, Todd, Germino, Elizabeth, Leong, Jeffrey W, Magrini, Vincent J, Koul, Sunita, Keppel, Catherine R, Schneider, Stephanie E, Koboldt, Daniel C, Sullivan, Ryan P, Heinz, Michael E, Crosby, Seth D, Nagarajan, Rakesh, Ramsingh, Giridharan, Link, Daniel C, Ley, Timothy J, Mardis, Elaine R

“…Natural killer (NK) cells are innate lymphocytes important for early host defense against infectious pathogens and surveillance against malignant…”
Get full text

Regulation of the PMP22 gene through an intronic enhancer by Jones, Erin A, Lopez-Anido, Camila, Srinivasan, Rajini, Krueger, Courtney, Chang, Li-Wei, Nagarajan, Rakesh, Svaren, John

“…Successful myelination of the peripheral nervous system depends upon induction of major protein components of myelin, such as peripheral myelin protein 22…”
Get full text

Array-Based Comparative Genomic Hybridization Identifies CDK4 and FOXM1 Alterations as Independent Predictors of Survival in Malignant Peripheral Nerve Sheath Tumor by JINSHENG YU, DESHMUKH, Hrishikesh, LINDBERG, Guy M, GUTMANN, Rebecca J, EMNETT, Ryan J, SALAVAGGIONE, Lorena, GUTMANN, David H, NAGARAJAN, Rakesh, WATSON, Mark A, PERRY, Arie, PAYTON, Jacqueline E, DUNHAM, Christopher, SCHEITHAUER, Bernd W, TIHAN, Tarik, PRAYSON, Richard A, GUHA, Abhijit, BRIDGE, Julia A, FERNER, Rosalie E

“…Malignant peripheral nerve sheath tumors (MPNST) are highly aggressive sarcomas with variable patient survival and few known prognostically relevant genomic…”
Get full text

EGR2 Mutations in Inherited Neuropathies Dominant-Negatively Inhibit Myelin Gene Expression by Nagarajan, Rakesh, Svaren, John, Le, Nam, Araki, Toshiyuki, Watson, Mark, Milbrandt, Jeffrey

“…The identification of EGR2 mutations in patients with neuropathies and the phenotype Egr2/Krox20−/− have demonstrated that the Egr2 transcription factor is…”
Get full text

Mechanisms of transcriptional regulation by Rb-E2F segregate by biological pathway by YOUNG, Arthur P, NAGARAJAN, Rakesh, LONGMORE, Gregory D

“…The E2F family of transcription factors are critical regulators of the cell cycle and have also been implicated in apoptosis, development, DNA damage…”
Get full text

Locus-wide identification of Egr2/Krox20 regulatory targets in myelin genes by Jang, Sung-Wook, Srinivasan, Rajini, Jones, Erin A, Sun, Guannan, Keles, Sunduz, Krueger, Courtney, Chang, Li-Wei, Nagarajan, Rakesh, Svaren, John

“…J. Neurochem. (2010) 115, 1409-1420. ABSTRACT: Myelination of peripheral nerves by Schwann cells depends upon a gene regulatory network controlled by early…”
Get full text

A systematic model to predict transcriptional regulatory mechanisms based on overrepresentation of transcription factor binding profiles by Chang, Li-Wei, Nagarajan, Rakesh, Magee, Jeffrey A, Milbrandt, Jeffrey, Stormo, Gary D

“…An important aspect of understanding a biological pathway is to delineate the transcriptional regulatory mechanisms of the genes involved. Two important tasks…”
Get full text

Expression and function of PML-RARA in the hematopoietic progenitor cells of Ctsg-PML-RARA mice by Wartman, Lukas D, Welch, John S, Uy, Geoffrey L, Klco, Jeffery M, Lamprecht, Tamara, Varghese, Nobish, Nagarajan, Rakesh, Ley, Timothy J

“…Because PML-RARA-induced acute promyelocytic leukemia (APL) is a morphologically differentiated leukemia, many groups have speculated about whether its…”
Get full text

Deciphering Peripheral Nerve Myelination by Using Schwann Cell Expression Profiling by Nagarajan, Rakesh, Le, Nam, Mahoney, Heather, Araki, Toshiyuki, Milbrandt, Jeffrey

“…Although mutations in multiple genes are associated with inherited demyelinating neuropathies, the molecular components and pathways crucial for myelination…”
Get full text

Analysis of Peripheral Nerve Expression Profiles Identifies a Novel Myelin Glycoprotein, MP11 by Ryu, Elizabeth J, Yang, Mao, Gustin, Jason A, Chang, Li-Wei, Freimuth, Robert R, Nagarajan, Rakesh, Milbrandt, Jeffrey

“…The myelin sheath insulates axons and allows for rapid salutatory conduction in the nervous system of all vertebrates. The formation of peripheral myelin…”
Get full text

Identification of transcriptional regulatory networks specific to pilocytic astrocytoma by Deshmukh, Hrishikesh, Yu, Jinsheng, Shaik, Jahangheer, MacDonald, Tobey J, Perry, Arie, Payton, Jacqueline E, Gutmann, David H, Watson, Mark A, Nagarajan, Rakesh

“…Pilocytic Astrocytomas (PAs) are common low-grade central nervous system malignancies for which few recurrent and specific genetic alterations have been…”
Get full text

Functional Compensation by Egr4 in Egr1-Dependent Luteinizing Hormone Regulation and Leydig Cell Steroidogenesis by Tourtellotte, Warren G., Nagarajan, Rakesh, Bartke, Andrzej, Milbrandt, Jeffrey

“…The Egr family of zinc finger transcription factors, whose members are encoded by Egr1 (NGFI-A), Egr2 (Krox20),Egr3, and Egr4 (NGFI-C) regulate critical…”
Get full text

Expression Profiling of Murine Acute Promyelocytic Leukemia Cells Reveals Multiple Model-Dependent Progression Signatures by Walter, Matthew J., Park, John S., Lau, Steven K. M., Li, Xia, Lane, Andrew A., Nagarajan, Rakesh, Shannon, William D., Ley, Timothy J.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

MicroRNAs modulate Schwann cell response to nerve injury by reinforcing transcriptional silencing of dedifferentiation-related genes by Viader, Andreu, Chang, Li-Wei, Fahrner, Timothy, Nagarajan, Rakesh, Milbrandt, Jeffrey

“…In the peripheral nervous system, Schwann cells (SCs) surrounding damaged axons undergo an injury response that is driven by an intricate transcriptional…”
Get full text

Analysis of congenital hypomyelinating Egr2Lo/Lo nerves identifies Sox2 as an inhibitor of Schwann cell differentiation and myelination by Le, Nam, Nagarajan, Rakesh, Wang, James Y T, Araki, Toshiyuki, Schmidt, Robert E, Milbrandt, Jeffrey

“…Egr2 is a transcription factor required for peripheral nerve myelination in rodents, and mutations in Egr2 are associated with congenital hypomyelinating…”
Get full text