Search Results - "NAGAOKA, ISAO"

Recent advances in the research and management of sepsis-associated DIC by Iba, Toshiaki, Connors, Jean Marie, Nagaoka, Isao, Levy, Jerrold H

“…Disseminated intravascular coagulation (DIC) is a common and life-threatening complication in sepsis. Sepsis-associated DIC is recognized as the systemic…”
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Therapeutic Potential of Cathelicidin Peptide LL-37, an Antimicrobial Agent, in a Murine Sepsis Model by Nagaoka, Isao, Tamura, Hiroshi, Reich, Johannes

“…Among the mechanisms put-up by the host to defend against invading microorganisms, antimicrobial peptides represent the first line. In different species of…”
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Prevention of Metabolic Syndrome by Phytochemicals and Vitamin D by Santa, Kazuki, Kumazawa, Yoshio, Nagaoka, Isao

“…In recent years, attention has focused on the roles of phytochemicals in fruits and vegetables in maintaining and improving the intestinal environment and…”
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Phytochemicals and Vitamin D for a Healthy Life and Prevention of Diseases by Santa, Kazuki, Watanabe, Kenji, Kumazawa, Yoshio, Nagaoka, Isao

“…A variety of phytocompounds contained in medical plants have been used as medication, including Kampo (traditional Japanese) medicine. Phytochemicals are one…”
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The Potential Use of Vitamin D3 and Phytochemicals for Their Anti-Ageing Effects by Santa, Kazuki, Kumazawa, Yoshio, Watanabe, Kenji, Nagaoka, Isao

“…Unlike other vitamins, vitamin D3 is synthesised in skin cells in the body. Vitamin D3 has been known as a bone-related hormone. Recently, however, it has been…”
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Lipopolysaccharides and Cellular Senescence: Involvement in Atherosclerosis by Suzuki, Kaori, Susaki, Etsuo A., Nagaoka, Isao

“…Atherosclerosis is a chronic inflammatory disease of the vascular walls related to aging. Thus far, the roles of cellular senescence and bacterial infection in…”
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Bone Marrow Adipocytes Facilitate Fatty Acid Oxidation Activating AMPK and a Transcriptional Network Supporting Survival of Acute Monocytic Leukemia Cells by Tabe, Yoko, Yamamoto, Shinichi, Saitoh, Kaori, Sekihara, Kazumasa, Monma, Norikazu, Ikeo, Kazuho, Mogushi, Kaoru, Shikami, Masato, Ruvolo, Vivian, Ishizawa, Jo, Hail, Jr, Numsen, Kazuno, Saiko, Igarashi, Mamoru, Matsushita, Hiromichi, Yamanaka, Yasunari, Arai, Hajime, Nagaoka, Isao, Miida, Takashi, Hayashizaki, Yoshihide, Konopleva, Marina, Andreeff, Michael

“…Leukemia cells in the bone marrow must meet the biochemical demands of increased cell proliferation and also survive by continually adapting to fluctuations in…”
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Human Cathelicidin Peptide LL-37 Induces Cell Death in Autophagy-Dysfunctional Endothelial Cells by Suzuki, Kaori, Ohkuma, Mari, Someya, Akimasa, Mita, Tomoya, Nagaoka, Isao

“…Human cathelicidin LL-37 is an antimicrobial peptide that has a broad spectrum of antimicrobial activities but also acts on host cells to exert…”
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Chondroprotective action of glucosamine, a chitosan monomer, on the joint health of athletes by Nagaoka, Isao, Tsuruta, Akifumi, Yoshimura, Masafumi

“…It has been reported that cartilage metabolism (type II collagen degradation) is enhanced in endurance athletes with intense joint loading. Notably,…”
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Antimicrobial cathelicidin peptide LL-37 inhibits the pyroptosis of macrophages and improves the survival of polybacterial septic mice by Hu, Zhongshuang, Murakami, Taisuke, Suzuki, Kaori, Tamura, Hiroshi, Reich, Johannes, Kuwahara-Arai, Kyoko, Iba, Toshiaki, Nagaoka, Isao

“…LL-37 is the only known member of the cathelicidin family of antimicrobial peptides in humans. In addition to its broad spectrum of antimicrobial activities,…”
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Antimicrobial cathelicidin peptide LL-37 inhibits the LPS/ATP-induced pyroptosis of macrophages by dual mechanism by Hu, Zhongshuang, Murakami, Taisuke, Suzuki, Kaori, Tamura, Hiroshi, Kuwahara-Arai, Kyoko, Iba, Toshiaki, Nagaoka, Isao

“…Pyroptosis is a caspase-1 dependent cell death, associated with proinflammatory cytokine production, and is considered to play a crucial role in sepsis…”
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Glucosamine Downregulates the IL-1β-Induced Expression of Proinflammatory Cytokine Genes in Human Synovial MH7A Cells by O-GlcNAc Modification-Dependent and -Independent Mechanisms by Someya, Akimasa, Ikegami, Takako, Sakamoto, Koji, Nagaoka, Isao

“…Osteoarthritis (OA) is one of the major joint diseases, and the synovial inflammation is involved in the pathogenesis and progression of OA. Glucosamine (GlcN)…”
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Antimicrobial peptide LL-37 ameliorates a murine sepsis model via the induction of microvesicle release from neutrophils by Kumagai, Yumi, Murakami, Taisuke, Kuwahara-Arai, Iba, Toshiaki, Reich, Johannes, Nagaoka, Isao

“…Sepsis is a life-threatening disease caused by systemic dys-regulated inflammatory response to infection. We previously revealed that LL-37, a human…”
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An Antimicrobial Cathelicidin Peptide, Human CAP18/LL-37, Suppresses Neutrophil Apoptosis via the Activation of Formyl-Peptide Receptor-Like 1 and P2X7 by Nagaoka, Isao, Tamura, Hiroshi, Hirata, Michimasa

“…Peptide antibiotics possess the potent antimicrobial activities against invading microorganisms and contribute to the innate host defense. An antibacterial…”
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Anti-Inflammatory Action of Dexmedetomidine on Human Microglial Cells by Yamazaki, Sho, Yamaguchi, Keisuke, Someya, Akimasa, Nagaoka, Isao, Hayashida, Masakazu

“…Neuroinflammation, where inflammatory cytokines are produced in excess, contributes to the pathogenesis of delirium. Microglial cells play a central role in…”
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Is the neutrophil a 'prima donna' in the procoagulant process during sepsis? by Iba, Toshiaki, Miki, Takahiro, Hashiguchi, Naoyuki, Tabe, Yoko, Nagaoka, Isao

“…Activation of the coagulation system is a fundamental host defense mechanism. Microorganisms that have invaded the body are trapped and disposed of in clots…”
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Comparative analysis of COVID-19 responses in Japan and Africa: diet, phytochemicals, vitamin D, and gut microbiota in reducing mortality-A systematic review and meta-analysis by Santa, Kazuki, Tamaki, Raita, Watanabe, Kenji, Nagaoka, Isao

“…As the novel coronavirus disease 2019 (COVID-19) pandemic subsides, the clinical sequelae are becoming more problematic. Interestingly, the statistical data…”
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Outstanding Contributions of LAL Technology to Pharmaceutical and Medical Science: Review of Methods, Progress, Challenges, and Future Perspectives in Early Detection and Management of Bacterial Infections and Invasive Fungal Diseases by Tamura, Hiroshi, Reich, Johannes, Nagaoka, Isao

“…The blue blood of the horseshoe crab is a natural, irreplaceable, and precious resource that is highly valued by the biomedical industry. The Limulus amebocyte…”
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The Potential Use of Grape Phytochemicals for Preventing the Development of Intestine-Related and Subsequent Inflammatory Diseases by Santa, Kazuki, Kumazawa, Yoshio, Nagaoka, Isao

“…Grape phytochemicals prevent intestine-related and subsequent other inflammatory diseases. Phytochemicals and vitamin D are useful for the regulation of…”
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Effect of glucosamine on expression of type II collagen, matrix metalloproteinase and sirtuin genes in a human chondrocyte cell line by Igarashi, Mamoru, Sakamoto, Koji, Nagaoka, Isao

“…Glucosamine (GlcN) has been widely used to treat osteoarthritis (OA) in humans. However, the effects of GlcN on genes related to cartilage metabolism are still…”
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