Search Results - "NAGAO, Shizuko"
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Gut microbiome-derived phenyl sulfate contributes to albuminuria in diabetic kidney disease
Published in Nature communications (23-04-2019)“…Diabetic kidney disease is a major cause of renal failure that urgently necessitates a breakthrough in disease management. Here we show using untargeted…”
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Mitochondrial Abnormality Facilitates Cyst Formation in Autosomal Dominant Polycystic Kidney Disease
Published in Molecular and cellular biology (01-12-2017)“…Autosomal dominant polycystic kidney disease (ADPKD) constitutes the most inherited kidney disease. Mutations in the PKD1 and PKD2 genes, encoding the…”
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3
High Levels of Dietary Lard or Sucrose May Aggravate Lysosomal Renal Injury in Non-Obese, Streptozotocin-Injected CD-1 Mice Provided Isocaloric Diets
Published in Journal of Nutritional Science and Vitaminology (31-08-2021)“…Daily fat and sugar intake has increased in Japan, while total energy intake has decreased. However, the number of type 2 diabetes mellitus patients has…”
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4
Strategy for generation of replication-competent recombinant rotaviruses expressing multiple foreign genes
Published in Journal of general virology (12-04-2021)“…With the recent establishment of robust reverse genetics systems for rotavirus, rotavirus is being developed as a vector to express foreign genes. However,…”
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5
Treatment of tubular damage in high-fat-diet-fed obese mice using sodium-glucose co-transporter inhibitors
Published in PloS one (13-02-2023)“…A long-term high-fat diet (HFD) causes obesity and changes in renal lipid metabolism and lysosomal dysfunction in mice, causing renal damage. Sodium-glucose…”
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Generation of Recombinant Authentic Live Attenuated Human Rotavirus Vaccine Strain RIX4414 (Rotarix ® ) from Cloned cDNAs Using Reverse Genetics
Published in Viruses (25-07-2024)“…The live attenuated human rotavirus vaccine strain RIX4414 (Rotarix ) is used worldwide to prevent severe rotavirus-induced diarrhea in infants. This strain…”
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Distinct oxylipin alterations in diverse models of cystic kidney diseases
Published in Biochimica et biophysica acta. Molecular and cell biology of lipids (01-12-2017)“…Cystic kidney diseases are characterized by multiple renal cysts and are the leading cause of inherited renal disease. Oxylipins are bioactive lipids derived…”
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Examination of postmortem changes in the lungs, trachea, and bronchi in a rat model imaged with small-animal computed tomography
Published in Fujita Medical Journal (01-05-2023)“…Objectives: As less autopsies are performed, the need for postmortem computed tomography (PMCT) as an alternative is increasing. It is important to know how…”
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9
Rotavirus incapable of NSP6 expression can cause diarrhea in suckling mice
Published in Journal of general virology (31-05-2022)“…The group A rotavirus (RVA) genome comprising 11 double-stranded RNAs encodes six structural proteins (VP1-VP4, VP6, and VP7) and six non-structural proteins…”
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10
Increased salt intake does not worsen the progression of renal cystic disease in high water-loaded PCK rats
Published in PloS one (14-03-2019)“…The anti-diuretic hormone arginine vasopressin is thought to be a detrimental factor in polycystic kidney disease (PKD). We previously reported that high water…”
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Increased water intake decreases progression of polycystic kidney disease in the PCK rat
Published in Journal of the American Society of Nephrology (01-08-2006)“…Renal enlargement in polycystic kidney disease (PKD) is caused by the proliferation of mural epithelial cells and transepithelial fluid secretion into the…”
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Beneficial effect of combined treatment with octreotide and pasireotide in PCK rats, an orthologous model of human autosomal recessive polycystic kidney disease
Published in PloS one (18-05-2017)“…Increased intracellular cyclic AMP (cAMP) in renal tubular epithelia accelerates the progression of polycystic kidney disease (PKD). Thus, decreasing cAMP…”
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13
A new murine ileostomy model: recycling stool prevents intestinal atrophy in the distal side of ileostomy
Published in Fujita Medical Journal (2021)“…Objectives: Proximal stoma creation in neonates results in growth failure and distal intestinal atrophy. “Recycling stool” consists of stool injection from the…”
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14
Animal Models for Human Polycystic Kidney Disease
Published in Experimental Animals (2012)“…Polycystic kidney disease (PKD) is a hereditary disorder with abnormal cellular proliferation, fluid accumulation in numerous cysts, remodeling of…”
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15
Cyclic AMP activates B-Raf and ERK in cyst epithelial cells from autosomal-dominant polycystic kidneys
Published in Kidney international (01-06-2003)“…Cyclic AMP activates B-Raf and ERK in cyst epithelial cells from autosomal-dominant polycystic kidneys. The proliferation of mural epithelial cells is a major…”
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16
Telmisartan ameliorates fibrocystic liver disease in an orthologous rat model of human autosomal recessive polycystic kidney disease
Published in PloS one (06-12-2013)“…Human autosomal recessive polycystic kidney disease (ARPKD) produces kidneys which are massively enlarged due to multiple cysts, hypertension, and congenital…”
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Renal Cyclooxygenase Products are Higher and Lipoxygenase Products are Lower in Early Disease in the pcy Mouse Model of Adolescent Nephronophthisis
Published in Lipids (01-01-2014)“…Nephronophthisis (NPHP) is a pediatric form of hereditary polycystic kidney disease (PKD), and is the leading cause of end stage renal disease in children. The…”
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Epithelial-to-mesenchymal transition in cyst lining epithelial cells in an orthologous PCK rat model of autosomal-recessive polycystic kidney disease
Published in American journal of physiology. Renal physiology (01-02-2011)“…In polycystic kidney disease (PKD), cyst lining cells show polarity abnormalities. Recent studies have demonstrated loss of cell contact in cyst cells,…”
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19
Effects of transgenic Pit-1 overexpression on calcium phosphate and bone metabolism
Published in Journal of bone and mineral metabolism (01-03-2010)“…The type III inorganic phosphate (Pi) transporter Pit-1 was previously found to be preferentially expressed in developing long bones. Several studies also…”
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Phosphate overload induces podocyte injury via type III Na-dependent phosphate transporter
Published in American journal of physiology. Renal physiology (01-04-2011)“…Uptake of P(i) at the cellular membrane is essential for the maintenance of cell viability. However, phosphate overload is also stressful for cells and can…”
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