Search Results - "NAGAO, Koji"

Medium-chain fatty acids: Functional lipids for the prevention and treatment of the metabolic syndrome by Nagao, Koji, Yanagita, Teruyoshi

“…Metabolic syndrome is a cluster of metabolic disorders, such as abdominal obesity, dyslipidemia, hypertension and impaired fasting glucose, that contribute to…”
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Exosomes maintain cellular homeostasis by excreting harmful DNA from cells by Takahashi, Akiko, Okada, Ryo, Nagao, Koji, Kawamata, Yuka, Hanyu, Aki, Yoshimoto, Shin, Takasugi, Masaki, Watanabe, Sugiko, Kanemaki, Masato T, Obuse, Chikashi, Hara, Eiji

“…Emerging evidence is revealing that exosomes contribute to many aspects of physiology and disease through intercellular communication. However, the biological…”
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Identification of genes regulated by lipids from seaweed Susabinori (Pyropia yezoensis) involved in the improvement of hepatic steatosis: Insights from RNA-Seq analysis in obese db/db mice by Iizasa, Sayaka, Nagao, Koji, Tsuge, Keisuke, Nagano, Yukio, Yanagita, Teruyoshi

“…Hepatic steatosis is an early stage in the progression of non-alcoholic fatty liver disease (NAFLD) and can lead to the development of non-alcoholic…”
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SmcHD1 underlies the formation of H3K9me3 blocks on the inactive X chromosome in mice by Ichihara, Saya, Nagao, Koji, Sakaguchi, Takehisa, Obuse, Chikashi, Sado, Takashi

“…Stable silencing of the inactive X chromosome (Xi) in female mammals is crucial for the development of embryos and their postnatal health. SmcHD1 is essential…”
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Defects in dosage compensation impact global gene regulation in the mouse trophoblast by Sakata, Yuka, Nagao, Koji, Hoki, Yuko, Sasaki, Hiroyuki, Obuse, Chikashi, Sado, Takashi

“…RNA, which is responsible for X inactivation, is a key epigenetic player in the embryogenesis of female mammals. Of the several repeats conserved in RNA, the…”
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Eicosapentaenoic acid-containing polar lipids from seaweed Susabinori (Pyropia yezoensis) alleviate hepatic steatosis in obese db/db mice by Yanagita, Teruyoshi, Tsuge, Keisuke, Koga, Misato, Inoue, Nao, Nagao, Koji

“…Nonalcoholic fatty liver disease (NAFLD) is emerging as the most common liver disease in industrialized countries. Because hepatic steatosis is an early…”
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Genome-wide stability of the DNA replication program in single mammalian cells by Takahashi, Saori, Miura, Hisashi, Shibata, Takahiro, Nagao, Koji, Okumura, Katsuzumi, Ogata, Masato, Obuse, Chikashi, Takebayashi, Shin-ichiro, Hiratani, Ichiro

“…Here, we report a single-cell DNA replication sequencing method, scRepli-seq, a genome-wide methodology that measures copy number differences between…”
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Role of SmcHD1 in establishment of epigenetic states required for the maintenance of the X-inactivated state in mice by Sakakibara, Yuki, Nagao, Koji, Blewitt, Marnie, Sasaki, Hiroyuki, Obuse, Chikashi, Sado, Takashi

“…X inactivation in mammals is regulated by epigenetic modifications. Functional deficiency of SmcHD1 has been shown to cause de-repression of X-inactivated…”
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Anti-stress effects of rosemary (Rosmarinus officinalis L.) leaf extract on intestinal goblet cells and immobility of forced-swimming test in BALB/c mice by Kayashima, Tomoko, Nagao, Koji, Umino, Mituki, Kaikiri, Hiroko, Shibata, Sachi, Matsubara, Kiminori

“…We investigated the anti-stress effect of rosemary (Rosmarinus officinalis L.) leaf extract (RLE) on restraint-stressed mice and found that RLE alleviated…”
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Mapping replication timing domains genome wide in single mammalian cells with single-cell DNA replication sequencing by Miura, Hisashi, Takahashi, Saori, Shibata, Takahiro, Nagao, Koji, Obuse, Chikashi, Okumura, Katsuzumi, Ogata, Masato, Hiratani, Ichiro, Takebayashi, Shin-ichiro

“…Replication timing (RT) domains are stable units of chromosome structure that are regulated in the context of development and disease. Conventional genome-wide…”
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Compositionally distinct nuclear pore complexes of functionally distinct dimorphic nuclei in the ciliate Tetrahymena by Iwamoto, Masaaki, Osakada, Hiroko, Mori, Chie, Fukuda, Yasuhiro, Nagao, Koji, Obuse, Chikashi, Hiraoka, Yasushi, Haraguchi, Tokuko

“…The nuclear pore complex (NPC), a gateway for nucleocytoplasmic trafficking, is composed of ∼30 different proteins called nucleoporins. It remains unknown…”
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Human inactive X chromosome is compacted through a PRC2-independent SMCHD1-HBiX1 pathway by Nozawa, Ryu-Suke, Nagao, Koji, Igami, Ken-Taro, Shibata, Sachiko, Shirai, Natsuko, Nozaki, Naohito, Sado, Takashi, Kimura, Hiroshi, Obuse, Chikashi

“…The human inactive X chromosome (Xi) compacts into a silent nuclear compartment, called a Barr body, that is enriched in repressive histone marks. Xi…”
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Dried and Fermented Powders of Edible Algae ( Neopyropia yezoensis ) Attenuate Hepatic Steatosis in Obese Mice by Nagao, Koji, Inoue, Nao, Tsuge, Keisuke, Oikawa, Akira, Kayashima, Tomoko, Yanagita, Teruyoshi

“…Edible algae is used as "Nori", its dried sheet product, in Japanese cuisine. Its lipid components reportedly improve hepatic steatosis in obese / mice. In…”
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Usp7-dependent histone H3 deubiquitylation regulates maintenance of DNA methylation by Yamaguchi, Luna, Nishiyama, Atsuya, Misaki, Toshinori, Johmura, Yoshikazu, Ueda, Jun, Arita, Kyohei, Nagao, Koji, Obuse, Chikashi, Nakanishi, Makoto

“…Uhrf1-dependent histone H3 ubiquitylation plays a crucial role in the maintenance of DNA methylation via the recruitment of the DNA methyltransferase Dnmt1 to…”
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Protein phosphatase 1 acts as a RIF1 effector to suppress DSB resection prior to Shieldin action by Isobe, Shin-Ya, Hiraga, Shin-ichiro, Nagao, Koji, Sasanuma, Hiroyuki, Donaldson, Anne D., Obuse, Chikashi

“…DNA double-strand breaks (DSBs) are repaired mainly by non-homologous end joining (NHEJ) or homologous recombination (HR). RIF1 negatively regulates resection…”
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An annexin A1-FPR1 interaction contributes to necroptosis of keratinocytes in severe cutaneous adverse drug reactions by Saito, Nao, Qiao, Hongjiang, Yanagi, Teruki, Shinkuma, Satoru, Nishimura, Keiko, Suto, Asuka, Fujita, Yasuyuki, Suzuki, Shotaro, Nomura, Toshifumi, Nakamura, Hideki, Nagao, Koji, Obuse, Chikashi, Shimizu, Hiroshi, Abe, Riichiro

“…Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are life-threatening, cutaneous adverse drug reactions that are accompanied by keratinocyte…”
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Time-Course Metabolomic Analysis: Production of Betaine Structural Analogs by Fungal Fermentation of Seaweed by Inoue, Nao, Tsuge, Keisuke, Yanagita, Teruyoshi, Oikawa, Akira, Nagao, Koji

“…Betaine structural analogs are compounds characterized by the presence of positive and negative charges in a single molecule and have been reported to have…”
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Asymmetrical localization of Nup107-160 subcomplex components within the nuclear pore complex in fission yeast by Asakawa, Haruhiko, Kojidani, Tomoko, Yang, Hui-Ju, Ohtsuki, Chizuru, Osakada, Hiroko, Matsuda, Atsushi, Iwamoto, Masaaki, Chikashige, Yuji, Nagao, Koji, Obuse, Chikashi, Hiraoka, Yasushi, Haraguchi, Tokuko

“…The nuclear pore complex (NPC) forms a gateway for nucleocytoplasmic transport. The outer ring protein complex of the NPC (the Nup107-160 subcomplex in humans)…”
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Study of Trans Fatty Acid Formation in Oil by Heating Using Model Compounds by Gotoh, Naohiro, Kagiono, Satoshi, Yoshinaga, Kazuaki, Mizobe, Hoyo, Nagai, Toshiharu, Yoshida, Akihiko, Beppu, Fumiaki, Nagao, Koji

“…The intake of trans fatty acids (TFAs) in foods changes the ratio of low density lipoprotein (LDL) to high density lipoprotein (HDL) cholesterol in blood,…”
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The Cholesterol Metabolite Cholest-5-en-3-One Alleviates Hyperglycemia and Hyperinsulinemia in Obese ( db / db ) Mice by Nagao, Koji, Inoue, Nao, Suzuki, Kunio, Shimizu, Takeshi, Yanagita, Teruyoshi

“…Dietary sterols are catabolized into various substances in the intestinal tract. Dietary 3-oxo derivatives of cholesterol and plant sterols (e.g.,…”
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