Search Results - "NAGAI, Yoshinori"

Allergic diseases: From bench to clinic - Contribution of the discovery of interleukin-5 by Yanagibashi, Tsutomu, Satoh, Mitsuo, Nagai, Yoshinori, Koike, Masamichi, Takatsu, Kiyoshi

“…T helper 2 cells produce a number of cytokines including inteleukin (IL)-5, IL-4 and IL-13. Group 2 innate lymphoid cells (ILC2s) also produce IL-5 under…”
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Isoliquiritigenin is a potent inhibitor of NLRP3 inflammasome activation and diet‐induced adipose tissue inflammation by Honda, Hiroe, Nagai, Yoshinori, Matsunaga, Takayuki, Okamoto, Naoki, Watanabe, Yasuharu, Tsuneyama, Koichi, Hayashi, Hiroaki, Fujii, Isao, Ikutani, Masashi, Hirai, Yoshikatsu, Muraguchi, Atsushi, Takatsu, Kiyoshi

“…Isoliquiritigenin, a component of Glycyrrhiza uralensis, is a potent inhibitor of the NLRP3 inflammasome, and suppresses diet‐induced obesity, adipose tissue…”
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Bidirectional crosstalk between neutrophils and adipocytes promotes adipose tissue inflammation by Watanabe, Yasuharu, Nagai, Yoshinori, Honda, Hiroe, Okamoto, Naoki, Yanagibashi, Tsutomu, Ogasawara, Masaru, Yamamoto, Seiji, Imamura, Ryu, Takasaki, Ichiro, Hara, Hiromitsu, Sasahara, Masakiyo, Arita, Makoto, Hida, Shigeaki, Taniguchi, Shun'ichiro, Suda, Takashi, Takatsu, Kiyoshi

“…Chronic activation of the IL‐1β system in adipose tissue on metabolic disorders is well demonstrated. However, a mechanism for its expression and activation in…”
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Regulatory Mechanisms for Adipose Tissue M1 and M2 Macrophages in Diet-Induced Obese Mice by FUJISAKA, Shiho, USUI, Isao, KOBAYASHI, Masashi, TOBE, Kazuyuki, BUKHARI, Agussalim, IKUTANI, Masashi, OYA, Takeshi, KANATANI, Yukiko, TSUNEYAMA, Koichi, NAGAI, Yoshinori, TAKATSU, Kiyoshi, URAKAZE, Masaharu

“…Regulatory Mechanisms for Adipose Tissue M1 and M2 Macrophages in Diet-Induced Obese Mice Shiho Fujisaka 1 , Isao Usui 1 , Agussalim Bukhari 1 , Masashi…”
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CD206+ M2-like macrophages regulate systemic glucose metabolism by inhibiting proliferation of adipocyte progenitors by Nawaz, Allah, Aminuddin, Aminuddin, Kado, Tomonobu, Takikawa, Akiko, Yamamoto, Seiji, Tsuneyama, Koichi, Igarashi, Yoshiko, Ikutani, Masashi, Nishida, Yasuhiro, Nagai, Yoshinori, Takatsu, Kiyoshi, Imura, Johji, Sasahara, Masakiyo, Okazaki, Yukiko, Ueki, Kohjiro, Okamura, Tadashi, Tokuyama, Kumpei, Ando, Akira, Matsumoto, Michihiro, Mori, Hisashi, Nakagawa, Takashi, Kobayashi, Norihiko, Saeki, Kumiko, Usui, Isao, Fujisaka, Shiho, Tobe, Kazuyuki

“…Adipose tissue resident macrophages have important roles in the maintenance of tissue homeostasis and regulate insulin sensitivity for example by secreting…”
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Effect of Wheat-Derived Arabinoxylan on the Gut Microbiota Composition and Colonic Regulatory T Cells by Chudan, Seita, Ishibashi, Riko, Nishikawa, Miyu, Tabuchi, Yoshiaki, Nagai, Yoshinori, Ikushiro, Shinichi, Furusawa, Yukihiro

“…The health benefits of wheat-derived arabinoxylan, a commonly consumed dietary fiber, have been studied for decades. However, its effect on the gut…”
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Bofutsushosan improves gut barrier function with a bloom of Akkermansia muciniphila and improves glucose metabolism in mice with diet-induced obesity by Fujisaka, Shiho, Usui, Isao, Nawaz, Allah, Igarashi, Yoshiko, Okabe, Keisuke, Furusawa, Yukihiro, Watanabe, Shiro, Yamamoto, Seiji, Sasahara, Masakiyo, Watanabe, Yoshiyuki, Nagai, Yoshinori, Yagi, Kunimasa, Nakagawa, Takashi, Tobe, Kazuyuki

“…Obesity and insulin resistance are associated with dysbiosis of the gut microbiota and impaired intestinal barrier function. Herein, we report that…”
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Beneficial Effects of Dietary Fiber in Young Barley Leaf on Gut Microbiota and Immunity in Mice by Chudan, Seita, Kurakawa, Takuto, Nishikawa, Miyu, Nagai, Yoshinori, Tabuchi, Yoshiaki, Ikushiro, Shinichi, Furusawa, Yukihiro

“…The health benefits of young barley leaves, rich in dietary fiber, have been studied for several decades; however, their beneficial effects on the intestinal…”
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Eplerenone prevented obesity-induced inflammasome activation and glucose intolerance by Wada, Tsutomu, Ishikawa, Akari, Watanabe, Eri, Nakamura, Yuto, Aruga, Yusuke, Hasegawa, Hayate, Onogi, Yasuhiro, Honda, Hiroe, Nagai, Yoshinori, Takatsu, Kiyoshi, Ishii, Yoko, Sasahara, Masakiyo, Koya, Daisuke, Tsuneki, Hiroshi, Sasaoka, Toshiyasu

“…Obesity-associated activation of the renin-angiotensin-aldosterone system is implicated in the pathogenesis of insulin resistance; however, influences of…”
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Inflammation-induced endothelial cell-derived extracellular vesicles modulate the cellular status of pericytes by Yamamoto, Seiji, Niida, Shumpei, Azuma, Erika, Yanagibashi, Tsutomu, Muramatsu, Masashi, Huang, Ting Ting, Sagara, Hiroshi, Higaki, Sayuri, Ikutani, Masashi, Nagai, Yoshinori, Takatsu, Kiyoshi, Miyazaki, Kenji, Hamashima, Takeru, Mori, Hisashi, Matsuda, Naoyuki, Ishii, Yoko, Sasahara, Masakiyo

“…Emerging lines of evidence have shown that extracellular vesicles (EVs) mediate cell-to-cell communication by exporting encapsulated materials, such as…”
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Activation and regulation of the pattern recognition receptors in obesity-induced adipose tissue inflammation and insulin resistance by Watanabe, Yasuharu, Nagai, Yoshinori, Takatsu, Kiyoshi

“…Obesity-associated chronic tissue inflammation is a key contributing factor to type 2 diabetes mellitus, and a number of studies have clearly demonstrated that…”
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Isoliquiritigenin Attenuates Adipose Tissue Inflammation and Metabolic Syndrome by Modifying Gut Bacteria Composition in Mice by Ishibashi, Riko, Furusawa, Yukihiro, Honda, Hiroe, Watanabe, Yasuharu, Fujisaka, Shiho, Nishikawa, Miyu, Ikushiro, Shinichi, Kurihara, Shin, Tabuchi, Yoshiaki, Tobe, Kazuyuki, Takatsu, Kiyoshi, Nagai, Yoshinori

“…Scope Isoliquiritigenin (ILG) has been reported to attenuate adipose tissue inflammation and metabolic disorder; however, the underlying mechanisms remain to…”
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Effect of soluble oat fiber on intestinal microenvironment and TNBS-induced colitis by Chudan, Seita, Ishibashi, Riko, Nishikawa, Miyu, Tabuchi, Yoshiaki, Nagai, Yoshinori, Ikushiro, Shinichi, Furusawa, Yukihiro

“…Soluble oat fibers, including β-glucan, have been shown to alter the gut microbiome composition and ameliorate DSS-induced colitis; however, the beneficial…”
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Toll-like Receptors on Hematopoietic Progenitor Cells Stimulate Innate Immune System Replenishment by Nagai, Yoshinori, Garrett, Karla P., Ohta, Shoichiro, Bahrun, Uleng, Kouro, Taku, Akira, Shizuo, Takatsu, Kiyoshi, Kincade, Paul W.

“…Toll-like receptors (TLRs) are best known for their ability to recognize microbial or viral components and initiate innate immune responses. We showed here…”
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Isoliquiritigenin Attenuates Adipose Tissue Inflammation in vitro and Adipose Tissue Fibrosis through Inhibition of Innate Immune Responses in Mice by Watanabe, Yasuharu, Nagai, Yoshinori, Honda, Hiroe, Okamoto, Naoki, Yamamoto, Seiji, Hamashima, Takeru, Ishii, Yoko, Tanaka, Miyako, Suganami, Takayoshi, Sasahara, Masakiyo, Miyake, Kensuke, Takatsu, Kiyoshi

“…Isoliquiritigenin (ILG) is a flavonoid derived from Glycyrrhiza uralensis and potently suppresses NLRP3 inflammasome activation resulting in the improvement of…”
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A subset of cerebrovascular pericytes originates from mature macrophages in the very early phase of vascular development in CNS by Yamamoto, Seiji, Muramatsu, Masashi, Azuma, Erika, Ikutani, Masashi, Nagai, Yoshinori, Sagara, Hiroshi, Koo, Bon-Nyeo, Kita, Satomi, O’Donnell, Erin, Osawa, Tsuyoshi, Takahashi, Hiroyuki, Takano, Ken-ichi, Dohmoto, Mitsuko, Sugimori, Michiya, Usui, Isao, Watanabe, Yasuhide, Hatakeyama, Noboru, Iwamoto, Takahiro, Komuro, Issei, Takatsu, Kiyoshi, Tobe, Kazuyuki, Niida, Shumpei, Matsuda, Naoyuki, Shibuya, Masabumi, Sasahara, Masakiyo

“…Pericytes are believed to originate from either mesenchymal or neural crest cells. It has recently been reported that pericytes play important roles in the…”
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Betulin Attenuates TGF-β1- and PGE2-Mediated Inhibition of NK Cell Activity to Suppress Tumor Progression and Metastasis in Mice by Ogasawara, Masaru, Yamasaki-Yashiki, Shino, Hamada, Masahiro, Yamaguchi-Miyamoto, Tomomi, Kawasuji, Toru, Honda, Hiroe, Yanagibashi, Tsutomu, Ikutani, Masashi, Watanabe, Yasuharu, Fujimoto, Ryota, Matsunaga, Takayuki, Nakajima, Noriyuki, Nagai, Yoshinori, Takatsu, Kiyoshi

“…Transforming growth factor (TGF)-β1 and prostaglandin E2 (PGE2) are humoral factors critically involved in the induction of immunosuppression in the…”
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The Impact of Low‐Viscosity Soluble Dietary Fibers on Intestinal Microenvironment and Experimental Colitis: A Possible Preventive Application of Alpha‐Cyclodextrin in Intestinal Inflammation by Yamanouchi, Yuka, Chudan, Seita, Ishibashi, Riko, Ohue‐Kitano, Ryuji, Nishikawa, Miyu, Tabuchi, Yoshiaki, Kimura, Ikuo, Nagai, Yoshinori, Ikushiro, Shinichi, Furusawa, Yukihiro

“…Scope The purpose of this study is to compare the impact of four low‐viscosity soluble dietary fibers (DFs) on the intestinal microenvironment, in terms of…”
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Impact of Vancomycin Treatment and Gut Microbiota on Bile Acid Metabolism and the Development of Non-Alcoholic Steatohepatitis in Mice by Kasai, Kaichi, Igarashi, Naoya, Tada, Yuki, Kani, Koudai, Takano, Shun, Yanagibashi, Tsutomu, Usui-Kawanishi, Fumitake, Fujisaka, Shiho, Watanabe, Shiro, Ichimura-Shimizu, Mayuko, Takatsu, Kiyoshi, Tobe, Kazuyuki, Tsuneyama, Koichi, Furusawa, Yukihiro, Nagai, Yoshinori

“…The potential roles of the gut microbiota in the pathogenesis of non-alcoholic fatty liver disease, including non-alcoholic steatohepatitis (NASH), have…”
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Roles of Macrophages in Advanced Liver Fibrosis, Identified Using a Newly Established Mouse Model of Diet-Induced Non-Alcoholic Steatohepatitis by Tada, Yuki, Kasai, Kaichi, Makiuchi, Nana, Igarashi, Naoya, Kani, Koudai, Takano, Shun, Honda, Hiroe, Yanagibashi, Tsutomu, Watanabe, Yasuharu, Usui-Kawanishi, Fumitake, Furusawa, Yukihiro, Ichimura-Shimizu, Mayuko, Tabuchi, Yoshiaki, Takatsu, Kiyoshi, Tsuneyama, Koichi, Nagai, Yoshinori

“…Macrophages play critical roles in the pathogenesis of non-alcoholic steatohepatitis (NASH). However, it is unclear which macrophage subsets are critically…”
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