Search Results - "NAGAI, YOKO"

Analysis of endometrial microbiota by 16S ribosomal RNA gene sequencing among infertile patients: a single‐center pilot study by Kyono, Koichi, Hashimoto, Tomoko, Nagai, Yoko, Sakuraba, Yoshiyuki

“…Purpose The present study aimed to analyze the endometrial and vaginal microbiome among a Japanese infertile population by sequencing and the impact of the…”
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Comprehensive preclinical pharmacokinetic evaluations of trastuzumab deruxtecan (DS-8201a), a HER2-targeting antibody-drug conjugate, in cynomolgus monkeys by Nagai, Yoko, Oitate, Masataka, Shiozawa, Hideyuki, Ando, Osamu

“…Trastuzumab deruxtecan (DS-8201a) is an antibody-drug conjugate (ADC) composed of a monoclonal antibody targeting human epidermal growth factor receptor 2…”
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Characterization of Microbiota in Endometrial Fluid and Vaginal Secretions in Infertile Women with Repeated Implantation Failure by Sakuraba, Yoshiyuki, Arai, Wataru, Nagai, Yoko, Kitaya, Kotaro, Ishikawa, Tomomoto

“…Studies suggest that persisting intrauterine bacterial infectious conditions such as chronic endometritis potentially impair the embryo implantation process…”
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Somatic inflammatory gene mutations in human ulcerative colitis epithelium by Nanki, Kosaku, Fujii, Masayuki, Shimokawa, Mariko, Matano, Mami, Nishikori, Shingo, Date, Shoichi, Takano, Ai, Toshimitsu, Kohta, Ohta, Yuki, Takahashi, Sirirat, Sugimoto, Shinya, Ishimaru, Kazuhiro, Kawasaki, Kenta, Nagai, Yoko, Ishii, Ryota, Yoshida, Kosuke, Sasaki, Nobuo, Hibi, Toshifumi, Ishihara, Soichiro, Kanai, Takanori, Sato, Toshiro

“…With ageing, normal human tissues experience an expansion of somatic clones that carry cancer mutations 1 – 7 . However, whether such clonal expansion exists…”
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A pilot study and case reports on endometrial microbiota and pregnancy outcome: An analysis using 16S rRNA gene sequencing among IVF patients, and trial therapeutic intervention for dysbiotic endometrium by Kyono, Koichi, Hashimoto, Tomoko, Kikuchi, Suguru, Nagai, Yoko, Sakuraba, Yoshiyuki

“…Purpose The present study aimed to analyze the pregnancy outcomes of IVF patients presenting Lactobacillus‐dominated microbiota (LDM) or…”
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Galvanic Skin Response (GSR)/Electrodermal/Skin Conductance Biofeedback on Epilepsy: A Systematic Review and Meta-Analysis by Nagai, Yoko, Jones, Christopher Iain, Sen, Arjune

“…Dynamic changes in psychophysiological arousal are directly expressed in the sympathetic innervation of the skin. This activity can be measured as tonic and…”
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Unveiling the intra-tumor fate of trastuzumab deruxtecan in a xenograft model to support its mechanism of action by Nagai, Yoko, Oitate, Masataka, Shibayama, Takahiro, Takakusa, Hideo, Watanabe, Nobuaki

“…Trastuzumab deruxtecan (T-DXd) is an antibody–drug conjugate used for cancer treatment comprising an anti-human epidermal growth factor receptor type 2 (HER2)…”
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Abnormal cleavage is involved in the self-correction of bovine preimplantation embryos by Nagai, Hiroki, Okada, Mai, Nagai, Yoko, Sakuraba, Yoshiyuki, Okae, Hiroaki, Suzuki, Ryosuke, Sugimura, Satoshi

“…Chromosome instability leading to aneuploidy during early cleavage is well known in humans and cattle. Partial compaction (PC), which occurs only in some…”
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Discovery of 3-amino-4-{(3S)-3-[(2-ethoxyethoxy)methyl]piperidin-1-yl}thieno[2,3-b]pyridine-2-carboxamide (DS96432529): A potent and orally active bone anabolic agent by Saito, Keiji, Shinozuka, Tsuyoshi, Nakao, Akira, Kunikata, Tomonori, Nakai, Daisuke, Nagai, Yoko, Naito, Satoru

“…[Display omitted] The continuing investigation of SAR of 3-aminothieno[2,3-b]pyridine-2-carboxamide derivatives has been described. In this study,…”
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A Zone Classification System for Risk Assessment of Idiosyncratic Drug Toxicity Using Daily Dose and Covalent Binding by NAKAYAMA, Shintaro, ATSUMI, Ryo, TAKAKUSA, Hideo, KOBAYASHI, Yoshimasa, KURIHARA, Atsushi, NAGAI, Yoko, NAKAI, Daisuke, OKAZAKI, Osamu

“…The risk of idiosyncratic drug toxicity (IDT) is of great concern to the pharmaceutical industry. Current hypotheses based on retrospective studies suggest…”
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Analysis of vaginal and endometrial microbiota communities in infertile women with a history of repeated implantation failure by Ichiyama, Takuhiko, Kuroda, Keiji, Nagai, Yoko, Urushiyama, Daichi, Ohno, Motoharu, Yamaguchi, Takashi, Nagayoshi, Motoi, Sakuraba, Yoshiyuki, Yamasaki, Fumio, Hata, Kenichiro, Miyamoto, Shingo, Itakura, Atsuo, Takeda, Satoru, Tanaka, Atsushi

“…Purpose To identify specific bacterial communities in vaginal and endometrial microbiotas as biomarkers of implantation failure by comprehensively analyzing…”
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Slow breathing and hypoxic challenge: cardiorespiratory consequences and their central neural substrates by Critchley, Hugo D, Nicotra, Alessia, Chiesa, Patrizia A, Nagai, Yoko, Gray, Marcus A, Minati, Ludovico, Bernardi, Luciano

“…Controlled slow breathing (at 6/min, a rate frequently adopted during yoga practice) can benefit cardiovascular function, including responses to hypoxia. We…”
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Next-generation sequencing of 16S rRNA for identification of invasive bacterial pathogens in a formalin-fixed paraffin-embedded placental specimen: a case report of perinatal fulminant Streptococcus pyogenes infection by Mariya, Tasuku, Sato, Toyotaka, Fujibe, Yuya, Ishido, Manami, Shimada, Hiroshi, Kubo, Terufumi, Nagai, Yoko, Arai, Wataru, Tanaka, Suguru E., Ashikawa, Kyota, Sakuraba, Yoshiyuki, Ishioka, Shinichi, Yokota, Shin-ichi, Saito, Tsuyoshi

“…Intrauterine infection is one of the most important causes of maternal death. In perinatal emergency, we often miss an opportunity to obtain culture specimens…”
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Synthesis and structure-activity relationship of 4-alkoxy-thieno[2,3-b]pyridine derivatives as potent alkaline phosphatase enhancers for osteoporosis treatment by Saito, Keiji, Shinozuka, Tsuyoshi, Nakao, Akira, Kiho, Toshihiro, Kunikata, Tomonori, Shiiki, Takeshi, Nagai, Yoko, Naito, Satoru

“…[Display omitted] The synthesis and structure-activity relationships of a novel series of 3-aminothieno[2,3-b]pyridine-2-carboxamides were explored. Our…”
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Divergent Conceptualization of Embodied Emotions in the English and Chinese Languages by Zhou, Pin, Critchley, Hugo, Nagai, Yoko, Wang, Chao

“…Traditional cognitive linguistic theories acknowledge that human emotions are embodied, yet they fail to distinguish the dimensions that reflect the direction…”
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Why I tense up when you watch me: Inferior parietal cortex mediates an audience’s influence on motor performance by Yoshie, Michiko, Nagai, Yoko, Critchley, Hugo D., Harrison, Neil A.

“…The presence of an evaluative audience can alter skilled motor performance through changes in force output. To investigate how this is mediated within the…”
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Emotional Appraisal Is Influenced by Cardiac Afferent Information by GRAY, Marcus A, MINATI, Ludovico, KEMP, Andrew H, BEACHER, Felix D, NAGAI, Yoko, HARRISON, Neil A, CRITCHLEY, Hugo D

“…Influential models highlight the central integration of bodily arousal with emotion. Some emotions, notably disgust, are more closely coupled to visceral state…”
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Dissecting axes of autonomic control in humans: Insights from neuroimaging by Critchley, Hugo D, Nagai, Yoko, Gray, Marcus A, Mathias, Christopher J

“…Abstract The combination of functional brain imaging with measurement of peripheral autonomic responses in humans can provide insight into the embodiment of…”
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Biofeedback Therapy and Sweat by Nagai, Yoko

“…Biofeedback training is a technique through which one can learn to control usually uncontrollable inner body functions, such as brain waves, heart rate or…”
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Association between insulin resistance and plasma amino acid profile in non‐diabetic Japanese subjects by Yamada, Chizumi, Kondo, Masumi, Kishimoto, Noriaki, Shibata, Takeo, Nagai, Yoko, Imanishi, Tadashi, Oroguchi, Takashige, Ishii, Naoaki, Nishizaki, Yasuhiro

“…Aims/Introduction Elevation of the branched‐chain amino acids (BCAAs), valine, leucine and isoleucine; and the aromatic amino acids, tyrosine and…”
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