Search Results - "NAGAHARA, SHUNJI"

Systemic delivery of siRNA specific to tumor mediated by atelocollagen: Combined therapy using siRNA targeting Bcl‐xL and cisplatin against prostate cancer by Mu, Ping, Nagahara, Shunji, Makita, Naoki, Tarumi, Yuzo, Kadomatsu, Kenji, Takei, Yoshifumi

“…The largest obstacle to the effective use of short interfering RNA (siRNA) in an animal body is the ability to deliver it to the target tissue. Here we showed…”
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Efficient Delivery of Small Interfering RNA to Bone-Metastatic Tumors by Using Atelocollagen in vivo by Takeshita, Fumitaka, Minakuchi, Yoshiko, Nagahara, Shunji, Honma, Kimi, Sasaki, Hideo, Hirai, Kotaro, Teratani, Takumi, Namatame, Nachi, Yamamoto, Yusuke, Hanai, Koji, Kato, Takashi, Sano, Akihiko, Ochiya, Takahiro

“…Silencing of gene expression by small interfering RNAs (siRNAs) is rapidly becoming a powerful tool for genetic analysis and represents a potential strategy…”
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Downregulation of Monocyte Chemoattractant Protein-1 Involving Short Interfering RNA Attenuates Hapten-induced Contact Hypersensitivity by Ishimoto, Takuji, Takei, Yoshifumi, Yuzawa, Yukio, Hanai, Koji, Nagahara, Shunji, Tarumi, Yuzo, Matsuo, Seiichi, Kadomatsu, Kenji

“…Contact hypersensitivity (CHS) is a common skin disease, presenting clinically as allergic contact dermatitis. At inflammatory sites in a typical CHS model in…”
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Atelocollagen-Mediated Systemic DDS for Nucleic Acid Medicines by HANAI, KOJI, TAKESHITA, FUMITAKA, HONMA, KIMI, NAGAHARA, SHUNJI, MAEDA, MIHO, MINAKUCHI, YOSHIKO, SANO, AKIHIKO, OCHIYA, TAKAHIRO

“…:  The goal of our research is to provide a practical platform for drug delivery in oligonucleotide therapy. We report here the efficacy of an…”
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Biomaterials for gene delivery: atelocollagen-mediated controlled release of molecular medicines by Ochiya, T, Nagahara, S, Sano, A, Itoh, H, Terada, M

“…Over the last decade, increasing attention has been paid to the development of systems to deliver drugs for long periods at controlled rates. Some of these…”
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Atelocollagen-Based Gene Transfer in Cells Allows High-Throughput Screening of Gene Functions by Honma, Kimi, Ochiya, Takahiro, Nagahara, Shunji, Sano, Akihiko, Yamamoto, Hanako, Hirai, Kotaro, Aso, Yu, Terada, Masaaki

“…We have previously demonstrated that Atelocollagen, used clinically for wound healing, is a reliable safe carrier for gene delivery. To obtain phenotypic…”
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Single‐injection ornithine decarboxylase‐directed antisense therapy using atelocollagen to suppress human cancer growth by Nakazawa, Kunihiko, Nemoto, Takahiro, Hata, Tomoko, Seyama, Yousuke, Nagahara, Shunji, Sano, Akihiko, Itoh, Hiroshi, Nagai, Yutaka, Kubota, Shunichiro

“…BACKGROUND Substantial evidence supports a direct role of ornithine decarboxylase (ODC) in the development and maintenance of human tumors. Although antisense…”
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Potential of atelocollagen-mediated systemic antisense therapeutics for inflammatory disease by Hanai, Koji, Kurokawa, Tomoyo, Minakuchi, Yoshiko, Maeda, Miho, Nagahara, Shunji, Miyata, Teruo, Ochiya, Takahiro, Sano, Akihiko

“…To study the possibility of using atelocollagen as an oligonucleotide (ODN) delivery carrier in vivo, the activity of formulated antisense ODN targeted against…”
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RPN2 gene confers docetaxel resistance in breast cancer by Ochiya, Takahiro, Honma, Kimi, Iwao-Koizumi, Kyoko, Takeshita, Fumitaka, Yamamoto, Yusuke, Yoshida, Teruhiko, Nishio, Kazuto, Nagahara, Shunji, Kato, Kikuya

“…Resistance to drugs is a clinical problem. Downregulating the gene RPN2 , which encodes part of an N -oligosaccharyl transferase complex, sensitized breast…”
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Atelocollagen-mediated Systemic Delivery Prevents Immunostimulatory Adverse Effects of siRNA in Mammals by Inaba, Shinichiro, Nagahara, Shunji, Makita, Naoki, Tarumi, Yuzo, Ishimoto, Takuji, Matsuo, Seiichi, Kadomatsu, Kenji, Takei, Yoshifumi

“…Short interfering RNA (siRNA) is a potent activator of the mammalian innate immune system. When considering possible clinical applications of siRNA for humans,…”
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Atelocollagen-mediated synthetic small interfering RNA delivery for effective gene silencing in vitro and in vivo by Minakuchi, Yoshiko, Takeshita, Fumitaka, Kosaka, Nobuyoshi, Sasaki, Hideo, Yamamoto, Yusuke, Kouno, Makiko, Honma, Kimi, Nagahara, Shunji, Hanai, Koji, Sano, Akihiko, Kato, Takashi, Terada, Masaaki, Ochiya, Takahiro

“…Silencing gene expression by siRNAs is rapidly becoming a powerful tool for the genetic analysis of mammalian cells. However, the rapid degradation of siRNA…”
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Atelocollagen for protein and gene delivery by Sano, Akihiko, Maeda, Miho, Nagahara, Shunji, Ochiya, Takahiro, Honma, Kimi, Itoh, Hiroshi, Miyata, Teruo, Fujioka, Keiji

“…Recent progress in recombinant gene technology and cell culture technology has made it possible to use protein and polynucleotides as effective drugs. However,…”
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New delivery system for plasmid DNA in vivo using atelocollagen as a carrier material: the Minipellet by Terada, Masaaki, Ochiya, Takahiro, Takahama, Yasushi, Nagahara, Shunji, Sumita, Yoshihiro, Hisada, Akihiko, Itoh, Hiroshi, Nagai, Yutaka

“…Skeletal muscle is a likely site for the delivery and expression of exogenous genes, both to treat local diseases and to act as a `bioreactor' for producing…”
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RPN2 gene confers docetaxel resistance in breast cancer by Honma, Kimi, Iwao-Koizumi, Kyoko, Takeshita, Fumitaka, Yamamoto, Yusuke, Yoshida, Teruhiko, Nishio, Kazuto, Nagahara, Shunji, Kato, Kikuya, Ochiya, Takahiro

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Correction: Corrigendum: RPN2 gene confers docetaxel resistance in breast cancer by Honma, Kimi, Iwao-Koizumi, Kyoko, Takeshita, Fumitaka, Yamamoto, Yusuke, Yoshida, Teruhiko, Nishio, Kazuto, Nagahara, Shunji, Kato, Kikuya, Ochiya, Takahiro

“…Nat. Med. 14, 939–948 (2008); published online 17 August 2008; corrected after print 7 October 2008 In the version of this article initially published, the…”
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Corrigendum: RPN2 gene confers docetaxel resistance in breast cancer by Honma, Kimi, Iwao-Koizumi, Kyoko, Takeshita, Fumitaka, Yamamoto, Yusuke, Yoshida, Teruhiko, Nishio, Kazuto, Nagahara, Shunji, Kato, Kikuya, Ochiya, Takahiro

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Hydrogel formation via hybridization of oligonucleotides derivatized in water-soluble vinyl polymers by Nagahara, Shunji, Matsuda, Takehisa

“…Succinimido-copolymers, poly(N,N-dimethylacrylamide-co-N-acryloyloxysuccinimide)s, were coupled with 5′-terminal-amino-modified oligodeoxyribonucleotides…”
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199. Efficient Inhibition of Bone Metastasis Via Systemic Delivery of siRNA Using Atelocollagen-Mediated Delivery System by Nagahara, Shunji, Takeshita, Fumitaka, Honma, Kimi, Minakuchi, Yoshiko, Sano, Akihiko, Ochiya, Takahiro

“…RNA interference has been one of the most powerful tool for genetic analysis, and much research on the development of siRNA for therapeutic use has progressed…”
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830. Efficient Transfer of Synthetic Small Interfering RNAs through Atelocollagen-Mediated Delivery System by Nagahara, Shunji, Minakuchi, Yoshiko, Takeshita, Fumitaka, Honma, Kimi, Hanai, Koji, Sano, Akihiko, Ochiya, Takahiro

“…Since it was observed that RNA interference which is an autologous protecting and regulating mechanism of eukaryotes can be worked artificially by introducing…”
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Atelocollagen for protein and gene delivery: Collagen in drug delivery and tissue engineering by SANO, Akihiko, MAEDA, Miho, NAGAHARA, Shunji, OCHIYA, Takahiro, HONMA, Kimi, ITOH, Hiroshi, MIYATA, Teruo, FUJIOKA, Keiji

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