Search Results - "NADEL, J. A"

Epidermal growth factor receptor-mediated innate immune responses and their roles in airway diseases by Burgel, P-R, Nadel, J. A

“…Inhaled air is contaminated with pathogens and particulates that may deposit in the airways and damage the host. In response to these invaders, the airway…”
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Roles of epidermal growth factor receptor activation in epithelial cell repair and mucin production in airway epithelium by Burgel, P-R, Nadel, J A

“…The epithelial cells lining the airways serve protective functions. The “barrier function” of the epithelium protects the individual from damage by inhaled…”
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Respiratory syncytial virus activates epidermal growth factor receptor to suppress interferon regulatory factor 1-dependent interferon-lambda and antiviral defense in airway epithelium by Kalinowski, A, Galen, B T, Ueki, I F, Sun, Y, Mulenos, A, Osafo-Addo, A, Clark, B, Joerns, J, Liu, W, Nadel, J A, Dela Cruz, C S, Koff, J L

“…Respiratory syncytial virus (RSV) persists as a significant human pathogen that continues to contribute to morbidity and mortality. In children, RSV is the…”
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Optogenetic stimulation of striatal patches modifies habit formation and inhibits dopamine release by Nadel, J. A., Pawelko, S. S., Scott, J. R., McLaughlin, R., Fox, M., Ghanem, M., van der Merwe, R., Hollon, N. G., Ramsson, E. S., Howard, C. D.

“…Habits are inflexible behaviors that develop after extensive repetition, and overreliance on habits is a hallmark of many pathological states. The striatum is…”
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Efficacy and safety of formoterol for the treatment of chronic obstructive pulmonary disease by Berger, W.E, Nadel, J.A

“…Summary Formoterol is a selective long-acting β2 -adrenergic receptor agonist (LABA) that provides significant and sustained bronchodilatory effect for up to…”
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Intranasal steroids decrease eosinophils but not mucin expression in nasal polyps by Burgel, P-R, Cardell, L.O, Ueki, I.F, Nadel, J.A

“…Increased mucin expression is a feature of nasal polyposis. Corticosteroids reduce polyp size and symptoms, but their effect on mucin production remains…”
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Interleukin-8: an important chemoattractant in sputum of patients with chronic inflammatory airway diseases by Richman-Eisenstat, J B, Jorens, P G, Hébert, C A, Ueki, I, Nadel, J A

“…Sputum from patients with cystic fibrosis, bronchiectasis, and chronic bronchitis contains neutrophils and neutrophil proteases, which have been implicated in…”
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Human Eosinophils Induce Mucin Production in Airway Epithelial Cells Via Epidermal Growth Factor Receptor Activation by Burgel, Pierre-Regis, Lazarus, Stephen C, Tam, Dominic Cheng-Wei, Ueki, Iris F, Atabai, Kamran, Birch, Martha, Nadel, Jay A

“…Eosinophil recruitment and mucus hypersecretion are characteristic of asthmatic airway inflammation, but eosinophils have not been shown to induce mucin…”
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Neutral endopeptidase modulates neurogenic inflammation by Nadel, J A

“…A noncholinergic, nonadrenergic nervous system has been described, involving the sensory nerves in the airways. Chemicals, dusts and other irritants stimulate…”
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Bronchodilation by pituitary adenylate cyclase-activating peptide and related peptides by Linden, A, Cardell, LO, Yoshihara, S, Nadel, JA

“…Pituitary adenylate cyclase-activating peptide (PACAP) is present in nerves in the vicinity of bronchial and vascular smooth muscle in the airways. At least…”
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NK1 receptors mediate leukocyte adhesion in neurogenic inflammation in the rat trachea by Baluk, P, Bertrand, C, Geppetti, P, McDonald, D M, Nadel, J A

“…In neurogenic inflammation, tachykinins trigger the adhesion of neutrophils and eosinophils to leaky venules. The goals of the present study were to determine…”
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Role of neutrophil elastase in hypersecretion in asthma by Nadel, JA, Takeyama, K, Agusti, C

“…Goblet cell (GC) hyperplasia and mucous plugging are common in patients with acute asthma. These patients also show neutrophil recruitment into the airways…”
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Neutrophil elastase and cathepsin G stimulate secretion from cultured bovine airway gland serous cells by SOMMERHOFF, C. P, NADEL, J. A, BASBAUM, C. B, CAUGHEY, G. H

“…To investigate the hypothesis that neutrophil proteases stimulate airway gland secretion, we studied the effect of human cathepsin G and elastase on secretion…”
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A morphometric study of mucins and small airway plugging in cystic fibrosis by Burgel, Pierre-Régis, Montani, David, Danel, Claire, Dusser, Daniel J, Nadel, Jay A

“…Rationale: Little knowledge exists on structural changes and plugging in small airways in cystic fibrosis. Objective: To characterise the extent of plugging…”
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Substance P and vasoactive intestinal peptide degradation by mast cell tryptase and chymase by Caughey, G H, Leidig, F, Viro, N F, Nadel, J A

“…The peptides substance P (SP) and vasoactive intestinal peptide (VIP) released from peptidergic neurons have potent effects on gland secretion and on smooth…”
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Pseudomonas aeruginosa induces MUC5AC production via epidermal growth factor receptor by Kohri, K, Ueki, I.F, Shim, J-J, Burgel, P-R, Oh, Y-M, Tam, D.C, Dao-Pick, T, Nadel, J.A

“…Hypersecretory disease associated with Pseudomonas aeruginosa (PA) infections is characterised by increased goblet cells and increased mucin production…”
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Cigarette smoke induces bronchoconstrictor hyperresponsiveness to substance P and inactivates airway neutral endopeptidase in the guinea pig. Possible role of free radicals by Dusser, D J, Djokic, T D, Borson, D B, Nadel, J A

“…We examined the effects of acute exposure to cigarette smoke on the airway responses to substance P in anesthetized guinea pigs and on the activity of airway…”
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Alternative mechanisms for tiotropium by Bateman, E.D, Rennard, S, Barnes, P.J, Dicpinigaitis, P.V, Gosens, R, Gross, N.J, Nadel, J.A, Pfeifer, M, Racké, K, Rabe, K.F, Rubin, B.K, Welte, T, Wessler, I

“…Abstract Tiotropium is commonly used in the treatment of chronic obstructive pulmonary disease. Although largely considered to be a long-acting bronchodilator,…”
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Nitric oxide synthase inhibitors attenuate ozone-induced airway inflammation in guinea pigs : Possible role of interleukin-8 by INOUE, H, AIZAWA, H, NAKANO, H, MATSUMOTO, K, KUWANO, K, NADEL, J. A, HARA, N

“…Nitric oxide (NO) is increased in exhaled air of asthmatics. We hypothesized that endogenous NO contributes to airway inflammation and hyperresponsiveness, and…”
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Randomised double-blind placebo-controlled study of the effect of inhibition of nitric oxide synthesis in bradykinin-induced asthma by Ricciardolo, F L, Geppetti, P, Mistretta, A, Nadel, J A, Sapienza, M A, Bellofiore, S, Di Maria, G U

“…Bronchoconstriction induced by bradykinin is reduced by the release of nitric oxide (NO) in the airways of guinea pigs. Inhaled NO is known to cause…”
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