Search Results - "NACHAGARI, Deepa"

Transporter-mediated protection against thiopurine-induced hematopoietic toxicity by Krishnamurthy, Partha, Schwab, Matthias, Takenaka, Kazumasa, Nachagari, Deepa, Morgan, Jessica, Leslie, Mark, Du, Weinan, Boyd, Kelli, Cheok, Meyling, Nakauchi, Hiromitsu, Marzolini, Catia, Kim, Richard B, Poonkuzhali, Balasubramanian, Schuetz, Erin, Evans, William, Relling, Mary, Schuetz, John D

“…Thiopurines are effective immunosuppressants and anticancer agents, but intracellular accumulation of their active metabolites (6-thioguanine nucleotides,…”
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Deoxycytidine Kinase Modulates the Impact of the ABC Transporter ABCG2 on Clofarabine Cytotoxicity by NAGAI, Shinjiro, TAKENAKA, Kazumasa, NACHAGARI, Deepa, ROSE, Charles, DOMONEY, Kali, SUN, Daxi, SPARREBOOM, Alex, SCHUETZ, John D

“…Purine nucleoside antimetabolites, such as clofarabine, are effective antileukemic agents. However, their effectiveness depends on an initial activation step…”
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Host Cell Cathepsins Potentiate Moloney Murine Leukemia Virus Infection by KUMAR, Pankaj, NACHAGARI, Deepa, FIELDS, Carolyn, FRANKS, John, ALBRITTON, Lorraine M

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Abcb11 Deficiency Induces Cholestasis Coupled to Impaired β-Fatty Acid Oxidation in Mice by Zhang, Yuanyuan, Li, Fei, Patterson, Andrew D., Wang, Yao, Krausz, Kristopher W., Neale, Geoffrey, Thomas, Sarah, Nachagari, Deepa, Vogel, Peter, Vore, Mary, Gonzalez, Frank J., Schuetz, John D.

“…The bile salt export pump (BSEP) is an ATP-binding cassette transporter that serves as the primary system for removing bile salts from the liver. In humans,…”
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ATP-dependent Mitochondrial Porphyrin Importer ABCB6 Protects against Phenylhydrazine Toxicity by Ulrich, Dagny L., Lynch, John, Wang, Yao, Fukuda, Yu, Nachagari, Deepa, Du, Guoqing, Sun, Daxi, Fan, Yiping, Tsurkan, Lyudmila, Potter, Philip M., Rehg, Jerold E., Schuetz, John D.

“…Abcb6 is a mammalian mitochondrial ATP-binding cassette (ABC) transporter that regulates de novo porphyrin synthesis. In previous studies, haploinsufficient…”
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Deregulated Hepatic Metabolism Exacerbates Impaired Testosterone Production in Mrp4-deficient Mice by Morgan, Jessica A., Cheepala, Satish B., Wang, Yao, Neale, Geoff, Adachi, Masashi, Nachagari, Deepa, Leggas, Mark, Zhao, Wenchen, Boyd, Kelli, Venkataramanan, Raman, Schuetz, John D.

“…The physiological role of multidrug resistance protein 4 (Mrp4, Abcc4) in the testes is unknown. We found that Mrp4 is expressed primarily in mouse and human…”
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Crucial Role for Phylogenetically Conserved Cytoplasmic Loop 3 in ABCC4 Protein Expression by Cheepala, Satish B., Bao, Ju, Nachagari, Deepa, Sun, Daxi, Wang, Yao, Zhong, Tao, Naren, Anjaparavanda P., Zheng, Jie, Schuetz, John D.

“…The ABC transporter ABCC4 is recognized as an ATP-dependent exporter of endogenous substances as well as an increasing variety of anionic chemotherapeutics. A…”
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Crucial role for phylogenetically conserved cytoplasmic loop 3 in ABCC4 protein expression by Cheepala, Satish B., Bao, Ju, Nachagari, Deepa, Sun, Daxi, Wang, Yao, Zhong, Tao P., Naren, Anjaparavanda P., Zheng, Jie, Schuetz, John D.

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Deregulated Hepatic Metabolism Exacerbates Impaired Testosterone Production in Mrp4‐Deficient Mice by Morgan, Jessica A, Cheepala, Satish B, Wang, Yao, Neale, Geoff, Adachi, Masashi, Nachagari, Deepa, Leggas, Mark, Boyd, Kelli, Schuetz, John D

“…Abstract only The physiological role of multidrug resistance protein 4 (Mrp4, Abcc4) in the testes is unknown. We found that Mrp4 is expressed primarily in…”
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Transporter-Mediated Protection against Thiopurine-lnduced Hematopoietic Toxicity by KRISHNAMURTHY, Partha, SCHWAB, Matthias, MARZOLINI, Catia, KIM, Richard B, POONKUZHALI, Balasubramanian, SCHUETZ, Erin, EVANS, William, RELLING, Mary, SCHUETZ, John D, TAKENAKA, Kazumasa, NACHAGARI, Deepa, MORGAN, Jessica, LESLIE, Mark, WEINAN DU, BOYD, Kelli, CHEOK, Meyling, NAKAUCHI, Hiromitsu

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