Search Results - "NABULSI, Nabeel"

Lower synaptic density is associated with depression severity and network alterations by Holmes, Sophie E., Scheinost, Dustin, Finnema, Sjoerd J., Naganawa, Mika, Davis, Margaret T., DellaGioia, Nicole, Nabulsi, Nabeel, Matuskey, David, Angarita, Gustavo A., Pietrzak, Robert H., Duman, Ronald S., Sanacora, Gerard, Krystal, John H., Carson, Richard E., Esterlis, Irina

“…Synaptic loss and deficits in functional connectivity are hypothesized to contribute to symptoms associated with major depressive disorder (MDD) and…”
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Imaging synaptic density in the living human brain by Finnema, Sjoerd J, Nabulsi, Nabeel B, Eid, Tore, Detyniecki, Kamil, Lin, Shu-Fei, Chen, Ming-Kai, Dhaher, Roni, Matuskey, David, Baum, Evan, Holden, Daniel, Spencer, Dennis D, Mercier, Joël, Hannestad, Jonas, Huang, Yiyun, Carson, Richard E

“…Chemical synapses are the predominant neuron-to-neuron contact in the central nervous system. Presynaptic boutons of neurons contain hundreds of vesicles…”
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In vivo evidence of lower synaptic vesicle density in schizophrenia by Radhakrishnan, Rajiv, Skosnik, Patrick D., Ranganathan, Mohini, Naganawa, Mika, Toyonaga, Takuya, Finnema, Sjoerd, Hillmer, Ansel T., Esterlis, Irina, Huang, Yiyun, Nabulsi, Nabeel, Carson, Richard E., D’Souza, Deepak C.

“…Decreased synaptic spine density has been the most consistently reported postmortem finding in schizophrenia (SCZ). A recently developed in vivo measure of…”
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Kinetic evaluation and test–retest reproducibility of [11C]UCB-J, a novel radioligand for positron emission tomography imaging of synaptic vesicle glycoprotein 2A in humans by Finnema, Sjoerd J, Nabulsi, Nabeel B, Mercier, Joël, Lin, Shu-fei, Chen, Ming-Kai, Matuskey, David, Gallezot, Jean-Dominique, Henry, Shannan, Hannestad, Jonas, Huang, Yiyun, Carson, Richard E

“…Synaptic vesicle glycoprotein 2A (SV2A) is ubiquitously present in presynaptic terminals. Here we report kinetic modeling and test–retest reproducibility…”
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PTSD is associated with neuroimmune suppression: evidence from PET imaging and postmortem transcriptomic studies by Bhatt, Shivani, Hillmer, Ansel T., Girgenti, Matthew J., Rusowicz, Aleksandra, Kapinos, Michael, Nabulsi, Nabeel, Huang, Yiyun, Matuskey, David, Angarita, Gustavo A., Esterlis, Irina, Davis, Margaret T., Southwick, Steven M., Friedman, Matthew J., Duman, Ronald S., Carson, Richard E., Krystal, John H., Pietrzak, Robert H., Cosgrove, Kelly P.

“…Despite well-known peripheral immune activation in posttraumatic stress disorder (PTSD), there are no studies of brain immunologic regulation in individuals…”
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In vivo measurement of widespread synaptic loss in Alzheimer's disease with SV2A PET by Mecca, Adam P., Chen, Ming‐Kai, O'Dell, Ryan S., Naganawa, Mika, Toyonaga, Takuya, Godek, Tyler A., Harris, Joanna E., Bartlett, Hugh H., Zhao, Wenzhen, Nabulsi, Nabeel B., Wyk, Brent C. Vander, Varma, Pradeep, Arnsten, Amy F. T., Huang, Yiyun, Carson, Richard E., Dyck, Christopher H.

“…Introduction Synaptic loss is a robust and consistent pathology in Alzheimer's disease (AD) and the major structural correlate of cognitive impairment…”
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Imaging robust microglial activation after lipopolysaccharide administration in humans with PET by Sandiego, Christine M., Gallezot, Jean-Dominique, Pittman, Brian, Nabulsi, Nabeel, Lim, Keunpoong, Lin, Shu-Fei, Matuskey, David, Lee, Jae-Yun, O’Connor, Kevin C., Huang, Yiyun, Carson, Richard E., Hannestad, Jonas, Cosgrove, Kelly P.

“…Neuroinflammation is associated with a broad spectrum of neurodegenerative and psychiatric diseases. The core process in neuroinflammation is activation of…”
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Synaptic density and cognitive performance in Alzheimer's disease: A PET imaging study with [11C]UCB‐J by Mecca, Adam P., O'Dell, Ryan S., Sharp, Emily S., Banks, Emmie R., Bartlett, Hugh H., Zhao, Wenzhen, Lipior, Sylwia, Diepenbrock, Nina G., Chen, Ming‐Kai, Naganawa, Mika, Toyonaga, Takuya, Nabulsi, Nabeel B., Vander Wyk, Brent C., Arnsten, Amy F. T., Huang, Yiyun, Carson, Richard E., Dyck, Christopher H.

“…Introduction For 30 years synapse loss has been referred to as the major pathological correlate of cognitive impairment in Alzheimer's disease (AD). However,…”
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Noninvasive quantification of [ 18 F]SynVesT-1 binding using simplified reference tissue model 2 by Naganawa, Mika, Gallezot, Jean-Dominique, Li, Songye, Nabulsi, Nabeel B, Henry, Shannan, Cai, Zhengxin, Matuskey, David, Huang, Yiyun, Carson, Richard E

“…[ F]SynVesT-1, a positron emission tomography (PET) radiotracer for the synaptic vesicle glycoprotein 2A (SV2A), demonstrates kinetics similar to [ C]UCB-J,…”
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Reduced synaptic vesicle protein 2A binding in temporal lobe epilepsy: A [11C]UCB‐J positron emission tomography study by Finnema, Sjoerd J., Toyonaga, Takuya, Detyniecki, Kamil, Chen, Ming‐Kai, Dias, Mark, Wang, Qianyu, Lin, Shu‐Fei, Naganawa, Mika, Gallezot, Jean‐Dominique, Lu, Yihuan, Nabulsi, Nabeel B., Huang, Yiyun, Spencer, Dennis D., Carson, Richard E.

“…Objective In this positron emission tomography (PET) study with [11C]UCB‐J, we evaluated synaptic vesicle glycoprotein 2A (SV2A) binding, which is decreased in…”
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Preliminary in vivo evidence of lower hippocampal synaptic density in cannabis use disorder by D’Souza, Deepak Cyril, Radhakrishnan, Rajiv, Naganawa, Mika, Ganesh, Suhas, Nabulsi, Nabeel, Najafzadeh, Soheila, Ropchan, Jim, Ranganathan, Mohini, Cortes-Briones, Jose, Huang, Yiyun, Carson, Richard E., Skosnik, Patrick

“…Cannabis is one of the most commonly and widely used psychoactive drugs. The rates of cannabis misuse have been increasing. Therefore, understanding the…”
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Sex differences in the brain's dopamine signature of cigarette smoking by Cosgrove, Kelly P, Wang, Shuo, Kim, Su-Jin, McGovern, Erin, Nabulsi, Nabeel, Gao, Hong, Labaree, David, Tagare, Hemant D, Sullivan, Jenna M, Morris, Evan D

“…Cigarette smoking is a major public health danger. Women and men smoke for different reasons and cessation treatments, such as the nicotine patch, are…”
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Imaging the effect of ketamine on synaptic density (SV2A) in the living brain by Holmes, Sophie E., Finnema, Sjoerd J., Naganawa, Mika, DellaGioia, Nicole, Holden, Daniel, Fowles, Krista, Davis, Margaret, Ropchan, Jim, Emory, Paul, Ye, Yunpeng, Nabulsi, Nabeel, Matuskey, David, Angarita, Gustavo A., Pietrzak, Robert H., Duman, Ronald S., Sanacora, Gerard, Krystal, John H., Carson, Richard E., Esterlis, Irina

“…The discovery of ketamine as a rapid and robust antidepressant marks the beginning of a new era in the treatment of psychiatric disorders. Ketamine is thought…”
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Comparison of [11C]UCB-J and [18F]FDG PET in Alzheimer’s disease: A tracer kinetic modeling study by Chen, Ming-Kai, Mecca, Adam P, Naganawa, Mika, Gallezot, Jean-Dominique, Toyonaga, Takuya, Mondal, Jayanta, Finnema, Sjoerd J, Lin, Shu-fei, O’Dell, Ryan S, McDonald, Julia W, Michalak, Hannah R, Vander Wyk, Brent, Nabulsi, Nabeel B, Huang, Yiyun, Arnsten, Amy FT, van Dyck, Christopher H, Carson, Richard E

“…[11C]UCB-J PET for synaptic vesicle glycoprotein 2 A (SV2A) has been proposed as a suitable marker for synaptic density in Alzheimer’s disease (AD). We…”
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Association of Aβ deposition and regional synaptic density in early Alzheimer's disease: a PET imaging study with [ 11 C]UCB-J by O'Dell, Ryan S, Mecca, Adam P, Chen, Ming-Kai, Naganawa, Mika, Toyonaga, Takuya, Lu, Yihuan, Godek, Tyler A, Harris, Joanna E, Bartlett, Hugh H, Banks, Emmie R, Kominek, Victoria L, Zhao, Wenzhen, Nabulsi, Nabeel B, Ropchan, Jim, Ye, Yunpeng, Vander Wyk, Brent C, Huang, Yiyun, Arnsten, Amy F T, Carson, Richard E, van Dyck, Christopher H

“…Attempts to associate amyloid-β (Aβ) pathogenesis with synaptic loss in Alzheimer's disease (AD) have thus far been limited to small numbers of postmortem…”
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Social status and demographic effects of the kappa opioid receptor: a PET imaging study with a novel agonist radiotracer in healthy volunteers by Matuskey, David, Dias, Mark, Naganawa, Mika, Pittman, Brian, Henry, Shannan, Li, Songye, Gao, Hong, Ropchan, Jim, Nabulsi, Nabeel, Carson, Richard E, Huang, Yiyun

“…Kappa opioid receptors (KORs) have been characterized as an aversive system in the brain and implicated in social behavior in preclinical models. This work…”
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Assessment of test-retest reproducibility of [18F]SynVesT-1, a novel radiotracer for PET imaging of synaptic vesicle glycoprotein 2A by Li, Songye, Naganawa, Mika, Pracitto, Richard, Najafzadeh, Soheila, Holden, Daniel, Henry, Shannan, Matuskey, David, Emery, Paul R., Cai, Zhengxin, Ropchan, Jim, Nabulsi, Nabeel, Carson, Richard E., Huang, Yiyun

“…Purpose Synaptic abnormalities are associated with many brain disorders. Recently, we developed a novel synaptic vesicle glycoprotein 2A (SV2A) radiotracer […”
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Vitamin D’s Capacity to Increase Amphetamine-Induced Dopamine Release in Healthy Humans: A Clinical Translational [11C]-PHNO Positron Emission Tomography Study by Worhunsky, Patrick D., Mignosa, Marcella M., Gallezot, Jean- Dominique, Pittman, Brian, Nabulsi, Nabeel B., Stryjewski, Adam, Jalilian-Khave, Laya, Trinko, Richard, DiLeone, Ralph J., Carson, Richard E., Malison, Robert T., Potenza, Marc N., Angarita, Gustavo A.

“…Dopaminergic tone and phasic release have transdiagnostic relevance. Preclinical research suggests that the active form of vitamin D, calcitriol, increases…”
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A single‐center, open‐label positron emission tomography study to evaluate brivaracetam and levetiracetam synaptic vesicle glycoprotein 2A binding in healthy volunteers by Finnema, Sjoerd J., Rossano, Samantha, Naganawa, Mika, Henry, Shannan, Gao, Hong, Pracitto, Richard, Maguire, Ralph P., Mercier, Joël, Kervyn, Sophie, Nicolas, Jean‐Marie, Klitgaard, Henrik, DeBruyn, Steven, Otoul, Christian, Martin, Paul, Muglia, Pierandrea, Matuskey, David, Nabulsi, Nabeel B., Huang, Yiyun, Kaminski, Rafal M., Hannestad, Jonas, Stockis, Armel, Carson, Richard E.

“…Summary Objective Brivaracetam (BRV) and levetiracetam (LEV) are antiepileptic drugs that bind synaptic vesicle glycoprotein 2A (SV2A). In vitro and in vivo…”
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Validation of a Simplified Tissue-to-Reference Ratio Measurement Using SUVR to Assess Synaptic Density Alterations in Alzheimer Disease with [ 11 C]UCB-J PET by Young, Juan J, O'Dell, Ryan S, Naganawa, Mika, Toyonaga, Takuya, Chen, Ming-Kai, Nabulsi, Nabeel B, Huang, Yiyun, Cooper, Emma, Miller, Alyssa, Lam, Jessica, Bates, Kara, Ruan, Audrey, Nelsen, Kimberly, Salardini, Elaheh, Carson, Richard E, van Dyck, Christopher H, Mecca, Adam P

“…Simplified methods of acquisition and quantification would facilitate the use of synaptic density imaging in multicenter and longitudinal studies of Alzheimer…”
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