Search Results - "N. Scholl, Zackary"

Partially native intermediates mediate misfolding of SOD1 in single-molecule folding trajectories by Sen Mojumdar, Supratik, N. Scholl, Zackary, Dee, Derek R., Rouleau, Logan, Anand, Uttam, Garen, Craig, Woodside, Michael T.

“…Prion-like misfolding of superoxide dismutase 1 (SOD1) is associated with the disease ALS, but the mechanism of misfolding remains unclear, partly because…”
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Single-molecule Force Spectroscopy Reveals the Calcium Dependence of the Alternative Conformations in the Native State of a βγ-Crystallin Protein by Scholl, Zackary N., Li, Qing, Yang, Weitao, Marszalek, Piotr E.

“…Although multidomain proteins predominate the proteome of all organisms and are expected to display complex folding behaviors and significantly greater…”
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Direct Observation of Multimer Stabilization in the Mechanical Unfolding Pathway of a Protein Undergoing Oligomerization by Scholl, Zackary N, Yang, Weitao, Marszalek, Piotr E

“…Understanding how protein oligomerization affects the stability of monomers in self-assembled structures is crucial to the development of new protein-based…”
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Single molecule mechanical manipulation for studying biological properties of proteins, DNA, and sugars by Scholl, Zackary N., Li, Qing, Marszalek, Piotr E.

“…For over 20 years there has been immense biological insight gained using single molecule mechanical measurements to understand properties of biomolecules. This…”
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Improving single molecule force spectroscopy through automated real-time data collection and quantification of experimental conditions by Scholl, Zackary N., Marszalek, Piotr E.

“…The benefits of single molecule force spectroscopy (SMFS) clearly outweigh the challenges which include small sample sizes, tedious data collection and…”
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Unraveling the Mysteries of Chaperone Interactions of the Myosin Head by Scholl, Zackary N., Marszalek, Piotr E.

“…Myosin is a ubiquitous protein that produces forces in the cell by converting the chemical energy from ATP hydrolysis into mechanical work. It is responsible…”
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Unraveling the Mechanical Unfolding Pathways of a Multidomain Protein: Phosphoglycerate Kinase by Li, Qing, Scholl, Zackary N., Marszalek, Piotr E.

“…Phosphoglycerate kinase (PGK) is a highly conserved enzyme that is crucial for glycolysis. PGK is a monomeric protein composed of two similar domains and has…”
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Competing Pathways and Multiple Folding Nuclei in a Large Multidomain Protein, Luciferase by Scholl, Zackary N., Yang, Weitao, Marszalek, Piotr E.

“…Proteins obtain their final functional configuration through incremental folding with many intermediate steps in the folding pathway. If known, these…”
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Chaperones Rescue Luciferase Folding by Separating Its Domains by Scholl, Zackary N., Yang, Weitao, Marszalek, Piotr E.

“…Over the last 50 years, significant progress has been made toward understanding how small single-domain proteins fold. However, very little is known about…”
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Capturing the Mechanical Unfolding Pathway of a Large Protein with Coiled-Coil Probes by Li, Qing, Scholl, Zackary N., Marszalek, Piotr E.

“…The folding behaviors and mechanisms of large multidomain proteins have remained largely uncharacterized, primarily because of the lack of appropriate research…”
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Correction to “Modular, Nondegenerate Polyprotein Scaffolds for Atomic Force Spectroscopy” by Scholl, Zackary N, Josephs, Eric A, Marszalek, Piotr E

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Relevance of the Speed and Direction of Pulling in Simple Modular Proteins by Plata, Carlos A, Scholl, Zackary N, Marszalek, Piotr E, Prados, Antonio

“…A theoretical framework capable of predicting the first unit that unfolds in pulled modular proteins has been recently introduced, for “fast enough” pulling…”
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Modular, Nondegenerate Polyprotein Scaffolds for Atomic Force Spectroscopy by Scholl, Zackary N, Josephs, Eric A, Marszalek, Piotr E

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Force Spectroscopy of Single Protein Molecules Using an Atomic Force Microscope by Scholl, Zackary N, Li, Qing, Josephs, Eric, Apostolidou, Dimitra, Marszalek, Piotr E

“…The determination of the folding process of proteins from their amino acid sequence to their native 3D structure is an important problem in biology. Atomic…”
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Origin of overstretching transitions in single-stranded nucleic acids by Scholl, Zackary N, Rabbi, Mahir, Lee, David, Manson, Laura, S-Gracz, Hanna, Marszalek, Piotr E

“…We combined single-molecule force spectroscopy with nuclear magnetic resonance measurements and molecular mechanics simulations to examine overstretching…”
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Capturing the Mechanical Unfolding Pathway of a Large Protein with Coiled-Coil Probes by Li, Qing, Scholl, Zackary N., Marszalek, Piotr E.

“…The folding behaviors and mechanisms of large multidomain proteins have remained largely uncharacterized, primarily because of the lack of appropriate research…”
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Reconstructing the Folding of Luciferase to Elucidate the Vectorial Folding Pathways of Large, Multidomain Proteins by Scholl, Zackary N., Yang, Weitao, Marszalek, Piotr

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Direct Observation of Multimer Stabilization in the Mechanical Unfolding Pathway of a Protein Undergoing Oligomerization by Scholl, Zackary N., Yang, Weitao, Marszalek, Piotr

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Chaperones Rescue Luciferase Folding by Separating its Domains by Scholl, Zackary N., Yang, Weitao, Marszalek, Piotr

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Single-Molecule Force-Spectroscopy Reveals the Calcium Dependency of Folding Intermediates in the Multidomain Protein S by Scholl, Zackary N., Li, Qing, Yang, Weitao, Marszalek, Piotr

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