Search Results - "N. K. Zenkov"

Mechanism of the Nrf2/Keap1/ARE signaling system by Tkachev, V. O., Menshchikova, E. B., Zenkov, N. K.

“…Nrf2 regulates expression of genes containing antioxidant-respons(iv)e element (ARE) in their promoters and plays a pivotal role among all redox-sensitive…”
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Keap1/Nrf2/ARE redox-sensitive signaling system as a pharmacological target by Zenkov, N. K., Menshchikova, E. B., Tkachev, V. O.

“…The redox-sensitive signaling system Keap1/Nrf2/ARE plays a key role in maintenance of cellular homeostasis under stress, inflammatory, carcinogenic, and…”
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Redox-dependent signaling system Nrf2/ARE in inflammation by Menshikova, E. B, Tkachev, V. O, Zenkov, N. K

“…The Nrf2 transcription factor plays a key role in cell defense against oxidative stress, as well as in counteracting the chemical and physical factors that…”
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Erythropoietin and Nrf2: key factors in the neuroprotection provided by apo-lactoferrin by Zakharova, E. T., Sokolov, A. V., Pavlichenko, N. N., Kostevich, V. A., Abdurasulova, I. N., Chechushkov, A. V., Voynova, I. V., Elizarova, A. Yu, Kolmakov, N. N., Bass, M. G., Semak, I. V., Budevich, A. I., Kozhin, P. M., Zenkov, N. K., Klimenko, V. M., Kirik, O. V., Korzhevskii, D. E., Menshchikova, E. B., Vasilyev, V. B.

“…Among the properties of lactoferrin (LF) are bactericidal, antianemic, immunomodulatory, antitumour, antiphlogistic effects. Previously we demonstrated its…”
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Mazes of Nrf2 regulation by Zenkov, N. K., Kozhin, P. M., Chechushkov, A. V., Martinovich, G. G., Kandalintseva, N. V., Menshchikova, E. B.

“…Nrf2 transcription factor plays a key role in maintaining cellular redox balance under stress and is a perspective target for oxidative stress-associated…”
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Antioxidant and antiinflammatory activity of new water-soluble sulfur-containing phenolic compounds by Zenkov, N K, Menshchikova, E B, Kandalintseva, N V, Oleynik, A S, Prosenko, A E, Gusachenko, O N, Shklyaeva, O A, Vavilin, V A, Lyakhovich, V V

“…We synthesized a series of structurally related water-soluble alkyl phenols - sodium 4-hydroxyphenyl propyl sulfonates and thiosulfonates with different number…”
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Effect of Phenol Inducing the Antioxidant Responsive Element on Drosophila Melanogaster Lifespan by Menshchikova, E. B., Zenkov, N. K., Weisman, N. Ya, Kandalintseva, N. V., Prosenko, A. E.

“…The effect of hydrophilic synthetic antioxidant TC-13 (3-(3’-tert-butyl-4’-hydroxyphenyl) propylthiosulfonate sodium) inducing the antioxidant-responsive…”
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Plant phenols and autophagy by Zenkov, N. K., Chechushkov, A. V., Kozhin, P. M., Kandalintseva, N. V., Martinovich, G. G., Menshchikova, E. B.

“…Many plant phenols (stilbenes, curcumins, catechins, flavonoids, etc.) are effective antioxidants and protect cells during oxidative stress. Extensive clinical…”
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Structural and Functional Characteristics for the Antiinflammatory Effect of New Water-Soluble Sulfur-Containing Phenol Antioxidants by Zenkov, N. K, Menshchikova, E. B, Kandalintseva, N. V, Prosenko, A. E

“…Structurally related phenols containing the p-alkylthiosulfonate substituent and partially hindered by tert-butyl groups were synthesized for the search and…”
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Combination of Methods for in Vitro Study of Antioxidant Properties of Chemical Compounds by Menshchikova, E. B, Zenkov, N. K, Kandalintseva, N. V, Prosenko, A. E

“…We proposed a combination of methods to study antioxidant properties of compounds, including evaluation of the capacity of the test preparations to inhibit…”
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Variability of the antioxidant effect on survival: Modeling in drosophila lines with different lifespan and lgl-tumor suppressor dosage by Weisman, N. Ya, Golubovsky, M. D, Zenkov, N. K, Menshchikova, E. B, Pashin, V. N

“…Different exogenic antioxidants and geroprotectors are used to decrease age abnormalities and enhance the human life span. However, the antioxidant effect on…”
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Active defense under oxidative stress. The antioxidant responsive element by Lyakhovich, V V, Vavilin, V A, Zenkov, N K, Menshchikova, E B

“…This review considers the mechanisms and factors that stimulate transcription of genes regulated by the antioxidant responsive element (ARE). The latter is…”
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Activation of Autophagy and Nrf2 Signaling in Human Breast Adenocarcinoma MCF-7 Cells by Novel Monophenolic Antioxidants by Menshchikova, E. B., Chechushkov, A. V., Kozhin, P. M., Kholshin, S. V., Kandalintseva, N. V., Martinovich, G. G., Zenkov, N. K.

“…The effect of novel water-soluble structurally related monophenolic compounds on the activity of two most important mechanisms of maintaining intracellular…”
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Synthetic Phenolic Antioxidant TS-13 Suppresses the Growth of Lewis Lung Carcinoma and Potentiates Oncolytic Effect of Doxorubicin by Men’shchikova, E. B., Zenkov, N. K., Kozhin, P. M., Chechushkov, A. V., Kovner, A. V., Khrapova, M. V., Kandalintseva, N. V., Martinovich, G. G.

“…ROS are important intracellular messengers; their ambiguous role in malignant processes was demonstrated in many studies. The effects of a synthetic phenolic…”
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Increased expression of autophagy and Nrf2-dependent signaling pathway genes by new monophenolic antioxidants depends on their structure by Khrapov, S. E., Kozhin, P. M., Khrapova, M. V., Serykh, A. E., Romakh, L. P., Pavlov, V. S., Chechushkov, A. V., Kholshin, S. V., Zenkov, N. K., Menshchikova, E. B.

“…Under certain conditions, both activators and inhibitors of Nrf2-dependent signaling and autophagy can serve as potential agents for the prevention, treatment,…”
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Autophagy as a protective mechanism in oxidative stress by Zenkov, N. K., Chehushkov, A. V., Kozhin, P. M., Martinovich, G. G., Kandalintseva, N. V., Menshchikova, E. B.

“…Autophagy is the main catabolic process required for the removal of damaged organelles, aggregated proteins and intracellular pathogens from cells. Oxidative…”
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Effect of new water-soluble phenolic antioxidants on the activity of Nrf2-driven enzymes, glutathione system, and Nrf2 translocation into the nucleus by E. B. Menshchikova, N. K. Zenkov, P. M. Kozhin, A. V. Chechushkov, V. S. Pavlov, L. P. Romakh, M. V. Khrapova, A. E. Serykh, O. B. Gritsyk, N. V. Kandalintseva

“…Understanding the role of reactive oxygen and nitrogen species in eustress (redox balance) and distress (oxidative stress) development poses new challenges for…”
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Anti-Infl ammatory Activity of TS-13, ARE-Inducing Phenol Antioxidant by Menshchikova, E. B., Tkachev, V. O., Zenkov, N. K., Lemza, A. E., Sharkova, T. V., Kandalintseva, N. V.

“…The protective effect of water-soluble TS-13 monophenol inducing the antioxidant-responsive element (ARE) system was studied on the models of acute…”
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Protective Effect of ARE-Inducing Phenol Antioxidant TS-13 in Chronic Inflammation by Menshchikova, E. B., Zenkov, N. K., Tkachev, V. O., Lemza, A. E., Kandalintseva, N. V.

“…The protective effect of partially substituted monophenol TS-13 inducing the Nrf2/Keap1/ARE signaling system was studied on the model of chronic inflammation…”
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Macrophage and Mycobacterium: The war without beginning or end by Zenkov, N. K., Chechushkov, A. V., Kozhin, P. M., Kolpakova, T. A., Menshchikova, E. B.

“…Mechanisms of macrophage polarization towards M1 phenotype or M2 phenotype, as well as of macrophage transformation into foam cells upon interaction with…”
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