Search Results - "N. Jose"

Modeling the Genetic Regulation of Cancer Metabolism: Interplay between Glycolysis and Oxidative Phosphorylation by Yu, Linglin, Lu, Mingyang, Jia, Dongya, Ma, Jianpeng, Ben-Jacob, Eshel, Levine, Herbert, Kaipparettu, Benny Abraham, Onuchic, José N

“…Abnormal metabolism is a hallmark of cancer, yet its regulation remains poorly understood. Cancer cells were considered to utilize primarily glycolysis for ATP…”
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Transferable model for chromosome architecture by Di Pierro, Michele, Zhang, Bin, Aiden, Erez Lieberman, Wolynes, Peter G., Onuchic, José N.

“…In vivo, the human genome folds into a characteristic ensemble of 3D structures. The mechanism driving the folding process remains unknown. We report a…”
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Stress, serotonin, and hippocampal neurogenesis in relation to depression and antidepressant effects by MAHAR, Ian, BAMBICO, Francis Rodriguez, MECHAWAR, Naguib, NOBREGA, José N

“…Chronic stressful life events are risk factors for developing major depression, the pathophysiology of which is strongly linked to impairments in serotonin…”
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Elucidating cancer metabolic plasticity by coupling gene regulation with metabolic pathways by Lu, Mingyang, Jung, Kwang Hwa, Park, Jun Hyoung, Yu, Linglin, Onuchic, José N., Kaipparettu, Benny Abraham, Levine, Herbert

“…Metabolic plasticity enables cancer cells to switch their metabolism phenotypes between glycolysis and oxidative phosphorylation (OXPHOS) during tumorigenesis…”
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Jagged–Delta asymmetry in Notch signaling can give rise to a Sender/Receiver hybrid phenotype by Boareto, Marcelo, Jolly, Mohit Kumar, Lu, Mingyang, Onuchic, José N., Clementi, Cecilia, Ben-Jacob, Eshel

“…Notch signaling pathway mediates cell-fate determination during embryonic development, wound healing, and tumorigenesis. This pathway is activated when the…”
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Densities and Viscosities of Mixtures of Two Ionic Liquids Containing a Common Cation by Almeida, Hugo F. D, Canongia Lopes, José N, Rebelo, Luís P. N, Coutinho, João A. P, Freire, Mara G, Marrucho, Isabel M

“…Density and dynamic viscosity data of binary mixtures of ionic liquids (ILs) were determined in this work, at temperatures from 283.15 to 363.15 K and at 0.1…”
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Compressive behavior of CNT-reinforced aluminum composites using molecular dynamics by Silvestre, Nuno, Faria, Bruno, Canongia Lopes, José N.

“…This paper presents a Molecular Dynamics (MD) study on the characterization of the compressive behavior of an aluminum (Al) material reinforced with carbon…”
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Decoding leader cells in collective cancer invasion by Vilchez Mercedes, Samuel A., Bocci, Federico, Levine, Herbert, Onuchic, José N., Jolly, Mohit Kumar, Wong, Pak Kin

“…Collective cancer invasion with leader–follower organization is increasingly recognized as a predominant mechanism in the metastatic cascade. Leader cells…”
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Interrogating the topological robustness of gene regulatory circuits by randomization by Huang, Bin, Lu, Mingyang, Jia, Dongya, Ben-Jacob, Eshel, Levine, Herbert, Onuchic, Jose N

“…One of the most important roles of cells is performing their cellular tasks properly for survival. Cells usually achieve robust functionality, for example,…”
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Direct-coupling analysis of residue coevolution captures native contacts across many protein families by Morcos, Faruck, Pagnani, Andrea, Lunt, Bryan, Bertolino, Arianna, Marks, Debora S, Sander, Chris, Zecchina, Riccardo, Onuchic, José N, Hwa, Terence, Weigt, Martin

“…The similarity in the three-dimensional structures of homologous proteins imposes strong constraints on their sequence variability. It has long been suggested…”
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Deep Brain Stimulation in Animal Models of Fear, Anxiety, and Posttraumatic Stress Disorder by Reznikov, Roman, Binko, Mary, Nobrega, José N, Hamani, Clement

“…Although medications and psychotherapy are often effective for the treatment of posttraumatic stress disorder (PTSD), 20-30% of patients do not respond to…”
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Nucleosomes play a dual role in regulating transcription dynamics by Brahmachari, Sumitabha, Tripathi, Shubham, Onuchic, José N, Levine, Herbert

“…Transcription has a mechanical component, as the translocation of the transcription machinery or RNA polymerase (RNAP) on DNA or chromatin is dynamically…”
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Systematic Study of the Thermophysical Properties of Imidazolium-Based Ionic Liquids with Cyano-Functionalized Anions by Neves, Catarina M. S. S, Kurnia, Kiki Adi, Coutinho, João A. P, Marrucho, Isabel M, Lopes, José N. Canongia, Freire, Mara G, Rebelo, Luís Paulo N

“…In the past few years, ionic liquids (ILs) with cyano-functionalized anions have shown to be improved candidates for electrochemical and separation…”
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Enhancing intracellular accumulation and target engagement of PROTACs with reversible covalent chemistry by Guo, Wen-Hao, Qi, Xiaoli, Yu, Xin, Liu, Yang, Chung, Chan-I, Bai, Fang, Lin, Xingcheng, Lu, Dong, Wang, Lingfei, Chen, Jianwei, Su, Lynn Hsiao, Nomie, Krystle J., Li, Feng, Wang, Meng C., Shu, Xiaokun, Onuchic, José N., Woyach, Jennifer A., Wang, Michael L., Wang, Jin

“…Current efforts in the proteolysis targeting chimera (PROTAC) field mostly focus on choosing an appropriate E3 ligase for the target protein, improving the…”
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Notch-Jagged signalling can give rise to clusters of cells exhibiting a hybrid epithelial/mesenchymal phenotype by Boareto, Marcelo, Jolly, Mohit Kumar, Goldman, Aaron, Pietilä, Mika, Mani, Sendurai A., Sengupta, Shiladitya, Ben-Jacob, Eshel, Levine, Herbert, Onuchic, Jose’ N.

“…Metastasis can involve repeated cycles of epithelial-to-mesenchymal transition (EMT) and its reverse mesenchymal-to-epithelial transition. Cells can also…”
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On the Formation of a Third, Nanostructured Domain in Ionic Liquids by Pereiro, Ana B, Pastoriza-Gallego, M. J, Shimizu, Karina, Marrucho, Isabel M, Lopes, José N. Canongia, Piñeiro, Manuel M, Rebelo, Luis Paulo N

“…The study of solid–fluid transitions in fluorinated ionic liquids using differential scanning calorimetry, rheology, and molecular modeling techniques is an…”
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Road-blocker HSP disease mutation disrupts pre-organization for ATP hydrolysis in kinesin through a second sphere control by Manna, Rabindra Nath, Onuchic, José N, Jana, Biman

“…Kinesin motor proteins perform several essential cellular functions powered by the adenosine triphosphate (ATP) hydrolysis reaction. Several single-point…”
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Magnesium controls aptamer-expression platform switching in the SAM-I riboswitch by Roy, Susmita, Hennelly, Scott P, Lammert, Heiko, Onuchic, José N, Sanbonmatsu, Karissa Y

“…Abstract Investigations of most riboswitches remain confined to the ligand-binding aptamer domain. However, during the riboswitch mediated transcription…”
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Ionic Liquids and Water: Hydrophobicity vs. Hydrophilicity by Rodrigues, Rita F., Freitas, Adilson A., Canongia Lopes, José N., Shimizu, Karina

“…Many chemical processes rely extensively on organic solvents posing safety and environmental concerns. For a successful transfer of some of those chemical…”
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Flowers with poricidal anthers and their complex interaction networks—Disentangling legitimate pollinators and illegitimate visitors by Mesquita-Neto, José N., Blüthgen, Nico, Schlindwein, Clemens

“…In flowers with poricidal anthers, pollen is not freely accessible and legitimate access is restricted to bees capable of vibrating the anthers. Despite the…”
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