Search Results - "N A Datson"

Specific Regulatory Motifs Predict Glucocorticoid Responsiveness of Hippocampal Gene Expression by Datson, N. A, Polman, J. A. E, de Jonge, R. T, van Boheemen, P. T. M, van Maanen, E. M. T, Welten, J, McEwen, B. S, Meiland, H. C, Meijer, O. C

“…The glucocorticoid receptor (GR) is an ubiquitously expressed ligand-activated transcription factor that mediates effects of cortisol in relation to adaptation…”
Get full text

Glucocorticoid signaling and stress-related limbic susceptibility pathway: About receptors, transcription machinery and microRNA by de Kloet, E.R, Fitzsimons, C.P, Datson, N.A, Meijer, O.C, Vreugdenhil, E

“…Abstract Background. Stress is essential for health, but if coping with stress fails, the action of the stress hormones cortisol and corticosterone (CORT)…”
Get full text

Low dystrophin variability between muscles and stable expression over time in Becker muscular dystrophy using capillary Western immunoassay by Koeks, Z., Janson, A. A., Beekman, C., Signorelli, M., van Duyvenvoorde, H. A., van den Bergen, J. C., Hooijmans, M. T., Alleman, I., Hegeman, I. M., Verschuuren, J. J. G. M., v. Deutekom, J. C., Spitali, P., Datson, N. A., Niks, E. H.

“…Becker muscular dystrophy (BMD) is the milder allelic variant of Duchenne muscular dystrophy, with higher dystrophin levels. To anticipate on results of…”
Get full text

Acute Activation of Hippocampal Glucocorticoid Receptors Results in Different Waves of Gene Expression Throughout Time by Morsink, M. C., Steenbergen, P. J., Vos, J. B., Karst, H., Joëls, M., De Kloet, E. R., Datson, N. A.

“…Several aspects of hippocampal cell function are influenced by adrenal‐secreted glucocorticoids in a delayed, genomic fashion. Previously, we used Serial…”
Get full text

A human glucocorticoid receptor gene variant that increases the stability of the glucocorticoid receptor beta-isoform mRNA is associated with rheumatoid arthritis by R H Derijk, M J Schaaf, G Turner, N A Datson, E Vreugdenhil, J Cidlowski, E R de Kloet, P Emery, E M Sternberg, S D Detera-Wadleigh

“…OBJECTIVE: To study the occurrence and function of polymorphism in the human glucocorticoid receptor (hGR) gene in rheumatoid arthritis (RA) and systemic lupus…”
Get full text

The dynamic pattern of glucocorticoid receptor‐mediated transcriptional responses in neuronal PC12 cells by Morsink, M. C., Joëls, M., Sarabdjitsingh, R. A., Meijer, O. C., De Kloet, E. R., Datson, N. A.

“…The aim of the current study was (i) to examine the overlap in the pattern of glucocorticoid receptor (GR)‐mediated transcriptional responses between different…”
Get full text

MicroSAGE: A modified procedure for serial analysis of gene expression in limited amounts of tissue by Datson, N.A., van der Perk-de Jong, J., van den Berg, M.P., de Kloet, E.R., Vreugdenhil, E.

“…Serial Analysis of Gene Expression (SAGE) is a powerful expression profiling method, allowing the analysis of the expression of thousands of transcripts…”
Get full text

Cloning and characterization of a novel bicoid -related homeobox transcription factor gene, RIEG , involved in Rieger syndrome by Alward, W. Lee M, Semina, Elena V, Small, Kent W, Datson, Nicole A, Siegel-Bartelt, Jacqueline, Murray, Jeffrey C, Bierke-Nelson, Diane, Reiter, Rebecca, Zabel, Bernhard U, Carey, John C, Bitoun, Pierre, Leysens, Nancy J

“…Rieger syndrome (RIEG) is an autosomal-dominant human disorder that includes anomalies of the anterior chamber of the eye, dental hypoplasia and a protuberant…”
Get full text

Rapid glucocorticoid effects on the expression of hippocampal neurotransmission-related genes by Morsink, M.C, Van Gemert, N.G, Steenbergen, P.J, Joëls, M, De Kloet, E.R, Datson, N.A

“…Abstract We previously assessed corticosterone mediated gene expression in acute explant hippocampal slices and found over 200 responsive genes 1, 3 and 5 h…”
Get full text

Expression profiling in laser-microdissected hippocampal subregions in rat brain reveals large subregion-specific differences in expression by Datson, N. A., Meijer, L., Steenbergen, P. J., Morsink, M. C., Van Der Laan, S., Meijer, O. C., De Kloet, E. R.

“…Expression profiling in the hippocampus is hampered by its cellular heterogeneity. The aim of this study was to evaluate the feasibility of using…”
Get full text

Genetic dissection of corticosterone receptor function in the rat hippocampus by Vreugdenhil, Erno, de Kloet, E.Ronald, Schaaf, Marcel, Datson, Nicole A

“…The hippocampus, a brain structure with a crucial role in learning and memory and an involvement in stress-related neurological or psychiatric disorders, is…”
Get full text

A molecular blueprint of gene expression in hippocampal subregions CA1, CA3, and DG is conserved in the brain of the common marmoset by Datson, N.A., Morsink, M.C., Steenbergen, P.J., Aubert, Y., Schlumbohm, C., Fuchs, E., de Kloet, E.R.

“…Recent studies in rodents have shown that there are significant differences in gene expression profiles between the hippocampal subregions CA1, CA3, and DG…”
Get full text

Scaling down SAGE: from miniSAGE to microSAGE by Datson, N A

“…Since Serial Analysis of Gene Expression (SAGE) was introduced more than a decade ago, it has been widely applied to characterise gene expression profiles in…”
Get more information

Identification of corticosteroid-responsive genes in rat hippocampus using serial analysis of gene expression by Datson, Nicole A., Van Der Perk, Jeannette, De Kloet, E. Ronald, Vreugdenhil, Erno

“…Adrenal corticosteroids (CORT) have a profound effect on the function of the hippocampus. This is mediated in a coordinated manner by mineralocorticoid (MR)…”
Get full text

Closing in on the Rieger syndrome gene on 4q25 : Mapping translocation breakpoints within a 50-kb region by DATSON, N. A, SEMINA, E, VAN STAALDUINEN, A. A. A, DAUWERSE, H. G, MEERSHOEK, E. J, HEUS, J. J, FRANTS, R. R, DEN DUNNEN, J. T, MURRAY, J. C, VAN OMMEN, G. J. B

“…Rieger syndrome (RGS) is an autosomal dominant disorder of morphogenesis affecting mainly the formation of the anterior eye chamber and of the teeth. RGS has…”
Get full text

Exclusion of epidermal growth factor and high-resolution physical mapping across the Rieger syndrome locus by SEMINA, E. V, DATSON, N. A, VAN OMMEN, G.-J, MURRAY, J. C, LEYSENS, N. J, ZABEL, B. U, CAREY, J. C, BELL, G. I, BITOUN, P, LINDGREN, C, STEVENSON, T, FRANTS, R. R

“…We have evaluated the 4q25-4q26 region where the autosomal dominant disorder Rieger syndrome has been previously mapped by linkage. We first excluded epidermal…”
Get full text

Altered hippocampal gene expression prior to the onset of spontaneous seizures in the rat post-status epilepticus model by Hendriksen, H., Datson, Nicole A., Ghijsen, Wim E. J. M., Van Vliet, Erwin A., Da Silva, Fernando H. Lopes, Gorter, Jan A., Vreugdenhil, Erno

“…Neuronal loss, gliosis and axonal sprouting in the hippocampal formation are characteristics of the syndrome of mesial temporal sclerosis (MTS). In the…”
Get full text

RFLP for the human retinoic acid receptor gene RAR-β by DATSON, N. A, VAN DER SAAG, P. T, OOSTRA, B. A

Get full text

Identification of Differentially Regulated Genes in Mildly Hyperlipidemic ApoE3-Leiden Mice by Use of Serial Analysis of Gene Expression by Kreeft, Arja J, Moen, Corina J.A, Hofker, Marten H, Frants, Rune R, Vreugdenhil, Erno, Gijbels, Marion J.J, Havekes, Louis M, Datson, Nicole A

“…Although genes determining lipoprotein homeostasis and atherosclerosis are the subject of intensive investigation, only a subset of these genes is known at…”
Get full text

Scanning for Genes in Large Genomic Regions: Cosmid-Based Exon Trapping of Multiple Exons in a Single Product by Datson, Nicole A., van de Vosse, Esther, Dauwerse, Hans G., Bout, Mattie, van Ommen, Gert-Jan B., den Dunnen, Johan T.

“…To facilitate the scanning of large genomic regions for the presence of exonic gene segments we have constructed a cosmid-based exon trap vector. The vector…”
Get full text