Search Results - "Núria Climent"

Immunomodulatory Activity of Tyrosine Kinase Inhibitors to Elicit Cytotoxicity Against Cancer and Viral Infection by Climent, Núria, Plana, Montserrat

“…Tyrosine kinase inhibitors (TKIs) of aberrant tyrosine kinase (TK) activity have been widely used to treat chronic myeloid leukemia (CML) for decades in…”
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Monocytes Are Major Players in the Prognosis and Risk of Infection After Acute Stroke by URRA, Xabier, CERVERA, Alvaro, OBACH, Victor, CLIMENT, Nuria, PLANAS, Anna M, CHAMORRO, Angel

“…Monocytes participate in adaptive and innate immune responses. Monocyte numbers increase in patients with stroke associated infection (SAI) or severe stroke…”
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Loading dendritic cells with gold nanoparticles (GNPs) bearing HIV-peptides and mannosides enhance HIV-specific T cell responses by Climent, Núria, García, Isabel, Marradi, Marco, Chiodo, Fabrizio, Miralles, Laia, Maleno, María José, Gatell, José María, García, Felipe, Penadés, Soledad, Plana, Montserrat

“…Gold nanoparticles (GNPs) decorated with glycans ameliorate dendritic cells (DC) uptake, antigen-presentation and T-cells cross-talk, which are important…”
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Immunomodulatory Activity of the Tyrosine Kinase Inhibitor Dasatinib to Elicit NK Cytotoxicity against Cancer, HIV Infection and Aging by Rodríguez-Agustín, Andrea, Casanova, Víctor, Grau-Expósito, Judith, Sánchez-Palomino, Sonsoles, Alcamí, José, Climent, Núria

“…Tyrosine kinase inhibitors (TKIs) have been extensively used as a treatment for chronic myeloid leukemia (CML). Dasatinib is a broad-spectrum TKI with…”
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Pharmacokinetics, the Immunological Impact, and the Effect on HIV Ex-Vivo Infectivity of Maraviroc, Raltegravir, and Lopinavir in Men Who Have Sex with Men Using Postexposure Prophylaxis by Leal, Lorna, Guardo, Alberto C, Bedoya, Luis M, Rodríguez de Miguel, Cristina, Climent, Núria, Rovira, Cristina, Beltrán, Manuela, Llach, Josep, Alcamí, Jose, Kashuba, Angela D M, Gatell, Jose M, Plana, Montserrat, García, Felipe

“…Most of the studies using the colorectal tissue explants challenge model have been conducted after one single dose and before reaching a steady state. We…”
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Evaluation of resistance to HIV-1 infection ex vivo of PBMCs isolated from patients with chronic myeloid leukemia treated with different tyrosine kinase inhibitors by Bermejo, Mercedes, Ambrosioni, Juan, Bautista, Guiomar, Climent, Núria, Mateos, Elena, Rovira, Cristina, Rodríguez-Mora, Sara, López-Huertas, María Rosa, García-Gutiérrez, Valentín, Steegmann, Juan Luis, Duarte, Rafael, Cervantes, Francisco, Plana, Montserrat, Miró, José M., Alcamí, José, Coiras, Mayte

“…Mechanismsof actionof different TKIs for avoiding HIV-1 infection of CD4+ T lymphocytes. 1) Preventing SAMHD1 phosphorylation; 2) impeding TCR-mediated…”
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Glutamate Released by Dendritic Cells as a Novel Modulator of T Cell Activation by Pacheco, Rodrigo, Oliva, Harold, Martinez-Navio, Jose M, Climent, Nuria, Ciruela, Francisco, Gatell, Jose M, Gallart, Teresa, Mallol, Josefa, Lluis, Carmen, Franco, Rafael

“…Adaptive immune responses begin after productive immunosynaptic contacts formation established in secondary lymphoid organs by dendritic cells (DC) presenting…”
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Loading dendritic cells with PLA-p24 nanoparticles or MVA expressing HIV genes induces HIV-1-specific T cell responses by Climent, Núria, Munier, Séverine, Piqué, Núria, García, Felipe, Pavot, Vincent, Primard, Charlotte, Casanova, Victor, Gatell, José María, Verrier, Bernard, Gallart, Teresa

“…Highlights • PLA-p24 on MDDCs induces maturation, cytokine secretion and CD8+ T cell responses. • Fully maturated PLA-p24 pulsed MDDCs are able to migrate…”
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Human immature monocyte-derived dendritic cells produce and secrete α-defensins 1–3 by Rodríguez‐García, Marta, Oliva, Harold, Climent, Núria, García, Felipe, Gatell, José M., Gallart, Teresa

“…Defensins are effector molecules of the innate immunity with a broad antimicrobial spectrum, including HIV. They also link innate and adaptive immunity,…”
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Dendrimers as nonviral vectors in dendritic cell-based immunotherapies against human immunodeficiency virus: steps toward their clinical evaluation by Vacas-Córdoba, Enrique, Climent, Núria, De La Mata, Francisco J, Plana, Montserrat, Gómez, Rafael, Pion, Marjorie, García, Felipe, Muñoz-Fernández, Maria Ángeles

“…Although the antiretroviral therapy has led to a long-term control of HIV-1, it does not cure the disease. Therefore, several strategies are being explored to…”
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Immunological dysfunction in HIV‐1‐infected individuals caused by impairment of adenosine deaminase‐induced costimulation of T‐cell activation by Martinez‐Navio, José M., Climent, Núria, Pacheco, Rodrigo, Garcia, Felipe, Plana, Montserrat, Nomdedeu, Meritxell, Oliva, Harold, Rovira, Cristina, Miralles, Laia, Gatell, José M., Gallart, Teresa, Mallol, Josefa, Lluis, Carme, Franco, Rafael

“…Summary The cell surface association between CD26 and adenosine deaminase (ADA) has a costimulatory function during T‐cell activation. Several studies have…”
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Impact of α-defensins1–3 on the maturation and differentiation of human monocyte-derived DCs. Concentration-dependent opposite dual effects by Rodríguez-García, Marta, Oliva, Harold, Climent, Núria, Escribese, Maria M, García, Felipe, Moran, Thomas M, Gatell, José M, Gallart, Teresa

“…Abstract α-defensins1–3 are potent antimicrobial molecules that also link innate and adaptive immunity, depending on the concentration range. However, their…”
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Ex vivo production of autologous whole inactivated HIV-1 for clinical use in therapeutic vaccines by Gil, Cristina, Climent, Núria, García, Felipe, Hurtado, Carmen, Nieto-Márquez, Sara, León, Agathe, García, M Teresa, Rovira, Cristina, Miralles, Laia, Dalmau, Judith, Pumarola, Tomás, Almela, Manel, Martinez-Picado, Javier, Lifson, Jeffrey D, Zamora, Laura, Miró, José M, Brander, Christian, Clotet, Bonaventura, Gallart, Teresa, Gatell, José M

“…Abstract This study provides a detailed description and characterization of the preparation of individualized lots of autologous heat inactivated HIV-1 virions…”
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Adenosine deaminase enhances T-cell response elicited by dendritic cells loaded with inactivated HIV by Climent, Núria, Martinez‐Navio, José M, Gil, Cristina, Garcia, Felipe, Rovira, Cristina, Hurtado, Carmen, Miralles, Laia, Gatell, José M, Gallart, Teresa, Mallol, Josefa, Lluis, Carme, Franco, Rafael

“…As host immunological defenses are impaired during HIV infection, it is difficult to elicit good responses when attempting to develop therapeutic vaccines…”
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14 Treatment with tyrosine kinase inhibitors make PBMCs from patients with chronic myeloid leukemia less susceptible to HIV-1 infection: control of CD4+ T cell activation to control HIV-1 replication by Mercedes Bermejo, Juan Ambrosioni, Guiomar Bautista, Núria Climent, Elena Mateos, Cristina Rovira, Rafael Duarte, Francisco Cervantes, Montserrat Plana, José M. Miró, José Alcamí, Mayte Coiras

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On metaphors in thinking about preparing mathematics for teaching by Scheiner, Thorsten, Godino, Juan D, Montes, Miguel A, Pino-Fan, Luis R, Climent, Nuria

“…This paper explores how different schools of thought in mathematics education think and speak about preparing mathematics for teaching by introducing and…”
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A Therapeutic Dendritic Cell-Based Vaccine for HIV-1 Infection by García, Felipe, Climent, Núria, Assoumou, Lambert, Gil, Cristina, González, Nuria, Alcamí, José, León, Agathe, Romeu, Joan, Dalmau, Judith, Martínez-Picado, Javier, Lifson, Jeff, Autran, Brigitte, Costagliola, Dominique, Clotet, Bonaventura, Gatell, Josep M, Plana, Montserrat, Gallart, Teresa

“…A double-blinded, controlled study of vaccination of untreated patients with chronic human immunodeficiency virus type 1 (HIV-1) infection with 3 doses of…”
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Natural killer cells act as an extrinsic barrier for in vivo reprogramming by Melendez, Elena, Chondronasiou, Dafni, Mosteiro, Lluc, Martínez de Villarreal, Jaime, Fernández-Alfara, Marcos, Lynch, Cian J, Grimm, Dirk, Real, Francisco X, Alcamí, José, Climent, Núria, Pietrocola, Federico, Serrano, Manuel

“…The ectopic expression of the transcription factors OCT4, SOX2, KLF4 and MYC (OSKM) enables reprogramming of differentiated cells into pluripotent embryonic…”
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Fraction Division Representation-Experience in a Teacher Education Course Focused on the Reference Unit by Faria Barcelos Gibim, Gabriela, Rifo, Laura, Climent, Nuria, Ribeiro, Miguel

“…This study focuses on the knowledge revealed and developed by Elementary Mathematics teachers, in a teacher education course related to the representation of…”
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Local barrier dysfunction identified by confocal laser endomicroscopy predicts bacterial translocation in HIV infection by Etcheverry-Rufino, Florencia, Lucero, Constanza, López-Cerón, María, Aleñar-Gelabert, Yoko, Fernández, Irene, Ugarte, Ainoa, Bargalló, Manel E., Goetz, Martin, Veloza, Luis, Bombí, Josep A., Pellisé, Maria, Leal, Lorna, Plana, Montserrat, Climent, Núria, García, Felipe

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