Search Results - "Nörenberg, M"

Role of Matricellular Proteins in Disorders of the Central Nervous System by Jayakumar, A. R., Apeksha, A., Norenberg, M. D.

“…Matricellular proteins (MCPs) are actively expressed non-structural proteins present in the extracellular matrix, which rapidly turnover and possess regulatory…”
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Oxidative Stress and Mitogen-Activated Protein Kinase Phosphorylation Mediate Ammonia-Induced Cell Swelling and Glutamate Uptake Inhibition in Cultured Astrocytes by Jayakumar, A. R, Panickar, K. S, Murthy, Ch. R. K, Norenberg, M. D

“…Hepatic encephalopathy (HE) is a major neurological complication in patients with severe liver failure. Elevated levels of ammonia have been strongly…”
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The mitochondrial permeability transition in neurologic disease by Norenberg, M.D., Rao, K.V. Rama

“…Mitochondria, being the principal source of cellular energy, are vital for cell life. Yet, ironically, they are also major mediators of cell death, either by…”
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Signaling factors in the mechanism of ammonia neurotoxicity by Norenberg, M. D, Rama Rao, K. V, Jayakumar, A. R

“…Mechanisms involved in hepatic encephalopathy (HE) still remain poorly understood. It is generally accepted that ammonia plays a major role in this disorder,…”
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Role of cerebral endothelial cells in the astrocyte swelling and brain edema associated with acute hepatic encephalopathy by Jayakumar, A.R, Tong, X.Y, Ospel, J, Norenberg, M.D

“…Highlights ► Ammonia stimulates endothelial cells (ECs) to release astrocyte swelling factors. ► Cultured ECs release free radicals and activate NF-κB when…”
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Mechanisms of ammonia-induced astrocyte swelling by NORENBERG, M. D, RAMA RAO, K. V, JAYAKUMAR, A. R

“…Astrocyte swelling represents the major factor responsible for the brain edema associated with fulminant hepatic failure (FHF). The edema may be of such…”
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New concepts in the mechanism of ammonia-induced astrocyte swelling by Norenberg, M D, Jayakumar, A R, Rama Rao, K V, Panickar, K S

“…It is generally accepted that astrocyte swelling forms the major anatomic substrate of the edema associated with acute liver failure (ALF) and that ammonia…”
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Sulfonylurea Receptor 1 Contributes to the Astrocyte Swelling and Brain Edema in Acute Liver Failure by Jayakumar, A. R., Valdes, V., Tong, X. Y., Shamaladevi, N., Gonzalez, W., Norenberg, M. D.

“…Astrocyte swelling (cytotoxic brain edema) is the major neurological complication of acute liver failure (ALF), a condition in which ammonia has been strongly…”
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Differential Response of Neural Cells to Trauma-Induced Swelling In Vitro by Jayakumar, A. R., Taherian, M., Panickar, K. S., Shamaladevi, N., Rodriguez, M. E., Price, B. G., Norenberg, M. D.

“…Brain edema and the associated increase in intracranial pressure are major consequences of traumatic brain injury (TBI) that accounts for most early deaths…”
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Glutamine in the mechanism of ammonia-induced astrocyte swelling by Jayakumar, A.R., Rao, K.V. Rama, Murthy, Ch.R.K., Norenberg, M.D.

“…Brain edema and the subsequent increase in intracranial pressure are the major neurological complications in fulminant hepatic failure (FHF). Brain edema in…”
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Aquaporin-4 in manganese-treated cultured astrocytes by Rama Rao, Kakulavarapu V., Jayakumar, Arumugam R., Reddy, Pichili V. B., Tong, Xiaoying, Curtis, Kevin M., Norenberg, M. D.

“…Manganese in excess is neurotoxic and causes CNS injury resembling that of Parkinson's disease. In brain, astrocytes predominantly take up and accumulate…”
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Role of oxidative stress in the ammonia-induced mitochondrial permeability transition in cultured astrocytes by Rama Rao, K.V., Jayakumar, A.R., Norenberg, M.D.

“…Ammonia is a neurotoxin that has been strongly implicated in the pathogenesis of hepatic encephalopathy (HE) and other neurological disorders, and astrocytes…”
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Neuronal Cell Death Induced by Mechanical Percussion Trauma in Cultured Neurons is not Preceded by Alterations in Glucose, Lactate and Glutamine Metabolism by Jayakumar, A. R., Bak, L. K., Rama Rao, K. V., Waagepetersen, H. S., Schousboe, A., Norenberg, M. D.

“…Traumatic brain injury (TBI) is a devastating neurological disorder that usually presents in acute and chronic forms. Brain edema and associated increased…”
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Ammonia-induced activation of p53 in cultured astrocytes: Role in cell swelling and glutamate uptake by Panickar, K.S., Jayakumar, A.R., Rao, K.V. Rama, Norenberg, M.D.

“…Cytotoxic brain edema, due principally to astrocyte swelling, is a major neurological complication of the acute form of hepatic encephalopathy (HE) (acute…”
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The First-Level Trigger of the HERA-B experiment: performance and expectations by Balagura, V, Bruinsma, M, Fleckenstein, H, Flammer, J, Gläss, J, Männer, R, Michetti, A, Nörenberg, M, Pernack, R, Popov, V, Ressing, D, Riu, I, Sbrizzi, A, Schwingenheuer, B, Somov, A, Uwer, U, Wahlberg, H, Wurz, A

“…HERA-B is a fixed target spectrometer which uses 920 GeV protons incident on various target materials. The experiment is aimed to study various aspects of…”
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Endothelial-astrocytic interactions in acute liver failure by Jayakumar, A. R., Norenberg, M. D.

“…Brain edema and the subsequent increase in intracranial pressure are major neurological complications of acute liver failure (ALF), and swelling of astrocytes…”
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NF-κB in the mechanism of brain edema in acute liver failure: Studies in transgenic mice by Jayakumar, A.R, Bethea, J.R, Tong, X.Y, Gomez, J, Norenberg, M.D

“…Abstract Astrocyte swelling and brain edema are major complications of the acute form of hepatic encephalopathy (acute liver failure, ALF). While elevated…”
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Brain edema in acute liver failure: Role of neurosteroids by Jayakumar, A.R., Ruiz-Cordero, R., Tong, X.Y., Norenberg, M.D.

“…•Studies have suggested the possibility of both cytotoxic and vasogenic edema in ALF.•Ammonia had no effect on the permeability of the BBB in an in vitro…”
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Astrocyte responses to CNS injury by Norenberg, M D

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Calcitonin gene-related peptide immunoreactivity in chronic human spinal cord injury by ACKERY, A. D, NORENBERG, M. D, KRASSIOUKOV, A

“…Histopathological study of the human spinal cord. International Collaboration on Repair Discoveries, Vancouver, BC, Canada. In animals, primary dorsal root…”
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