Search Results - "Németh, Balázs Csaba"

Misfolding-induced chronic pancreatitis in CPA1 N256K mutant mice is unaffected by global deletion of Ddit3/Chop by Németh, Balázs Csaba, Demcsák, Alexandra, Geisz, Andrea, Sahin-Tóth, Miklós

“…Genetic mutations in pancreatic digestive enzymes may cause protein misfolding, endoplasmic reticulum (ER) stress and chronic pancreatitis. The CPA1 N256K…”
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Risk of chronic pancreatitis in carriers of loss-of-function CTRC variants: A meta-analysis by Takáts, Amanda, Berke, Gergő, Gede, Noémi, Németh, Balázs Csaba, Witt, Heiko, Głuszek, Stanisław, Rygiel, Agnieszka Magdalena, Hegyi, Péter, Sahin-Tóth, Miklós, Hegyi, Eszter

“…The digestive protease chymotrypsin C (CTRC) protects the pancreas against pancreatitis by degrading potentially harmful trypsinogen. Loss-of-function genetic…”
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Novel p.G250A Mutation Associated with Chronic Pancreatitis Highlights Misfolding-Prone Region in Carboxypeptidase A1 (CPA1) by Sándor, Máté, Thiel, Franziska G, Schmid, Margit, Demcsák, Alexandra, Morales Granda, Nataly C, Németh, Balázs Csaba, Vajda, Sandor, Hoerning, André, Sahin-Tóth, Miklós

“…Inborn mutations in the digestive protease carboxypeptidase A1 (CPA1) gene may be associated with hereditary and idiopathic chronic pancreatitis (CP)…”
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The common truncation variant in pancreatic lipase related protein 2 (PNLIPRP2) is expressed poorly and does not alter risk for chronic pancreatitis by Németh, Balázs Csaba, Pesei, Zsófia Gabriella, Hegyi, Eszter, Szücs, Ákos, Szentesi, Andrea, Hegyi, Péter, Lowe, Mark E, Sahin-Tóth, Miklós

“…A nonsense variant (p.W358X) of human pancreatic lipase related protein 2 (PNLIPRP2) is present in different ethnic populations with a high allele frequency…”
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Relevance of α-defensins(HNP1-3) and defensin β-1 in diabetes by Balázs Csaba Németh Tamás Várkonyi Ferenc Somogyvári Csaba Lengyel Katalin Fehértemplomi Szabolcs Nyiraty Péter Kempler Yvette Mándi

“…AIM: To investigate the genetic background of human defensin expression in type 1 and 2 diabetes.METHODS: Associations between DEFA1/DEFA3 gene copy number…”
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Preclinical testing of dabigatran in trypsin-dependent pancreatitis by Pesei, Zsófia Gabriella, Jancsó, Zsanett, Demcsák, Alexandra, Németh, Balázs Csaba, Vajda, Sandor, Sahin-Tóth, Miklós

“…Pancreatitis, the inflammatory disorder of the pancreas, has no specific therapy. Genetic, biochemical, and animal model studies revealed that trypsin plays a…”
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Genetic Analysis of Human Chymotrypsin-Like Elastases 3A and 3B (CELA3A and CELA3B) to Assess the Role of Complex Formation between Proelastases and Procarboxypeptidases in Chronic Pancreatitis by Párniczky, Andrea, Hegyi, Eszter, Tóth, Anna Zsófia, Szücs, Ákos, Szentesi, Andrea, Vincze, Áron, Izbéki, Ferenc, Németh, Balázs Csaba, Hegyi, Péter, Sahin-Tóth, Miklós

“…Human chymotrypsin-like elastases 3A and 3B (CELA3A and CELA3B) are the products of gene duplication and share 92% identity in their primary structure. CELA3B…”
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SPINK1 Promoter Variants in Chronic Pancreatitis by Hegyi, Eszter, Geisz, Andrea, Sahin-Tóth, Miklós, Derikx, Monique H M, Németh, Balázs Csaba, Balázs, Anita, Hritz, István, Izbéki, Ferenc, Halász, Adrienn, Párniczky, Andrea, Takács, Tamás, Kelemen, Dezső, Sarlós, Patrícia, Hegyi, Péter, Czakó, László

“…Serine protease inhibitor Kazal type 1 (SPINK1) provides an important line of defense against premature trypsinogen activation within the pancreas. Our aim was…”
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CFTR p.F508del Mutation Carrier Status Is Not Associated With Biliary Acute Pancreatitis by Martonosi, Ágnes Rita, Németh, Balázs Csaba, Párniczky, Andrea, Vincze, Áron, Szentesi, Andrea, Erőss, Bálint, Sahin-Tóth, Miklós, Hegyi, Péter, Hegyi, Eszter

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Evolutionary expansion of polyaspartate motif in the activation peptide of mouse cationic trypsinogen limits autoactivation and protects against pancreatitis by Orekhova, Anna, Németh, Balázs Csaba, Jancsó, Zsanett, Geisz, Andrea, Mosztbacher, Dóra, Demcsák, Alexandra, Sahin-Tóth, Miklós

“…The activation peptide of mammalian trypsinogens typically contains a tetra-aspartate motif (positions P2-P5 in Schechter-Berger numbering) that inhibits…”
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A Common CCK-B Receptor Intronic Variant in Pancreatic Adenocarcinoma in a Hungarian Cohort by Balázs, Anita, Németh, Balázs Csaba, Ördög, Balázs, Hegyi, Eszter, Hritz, István, Czakó, László, Czimmer, József, Gódi, Szilárd, Csiszkó, Adrienn, Rakonczay, Jr, Zoltán, Párniczky, Andrea, Izbéki, Ferenc, Halász, Adrienn, Kahán, Zsuzsanna, Hegyi, Péter, Sahin-Tóth, Miklós

“…Variant c.811+32C>A in intron 4 of the cholecystokinin-B receptor gene (CCKBR) was reported to correlate with higher pancreatic cancer risk and poorer…”
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Natural single-nucleotide deletion in chymotrypsinogen C gene increases severity of secretagogue-induced pancreatitis in C57BL/6 mice by Geisz, Andrea, Jancsó, Zsanett, Németh, Balázs Csaba, Hegyi, Eszter, Sahin-Tóth, Miklós

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Genetic analysis of the bicarbonate secreting anion exchanger SLC26A6 in chronic pancreatitis by Balázs, Anita, Ruffert, Claudia, Hegyi, Eszter, Hritz, István, Czakó, László, Takács, Tamás, Szepes, Zoltán, Németh, Balázs Csaba, Gervain, Judit, Izbéki, Ferenc, Halász, Adrienn, Kelemen, Dezső, Szmola, Richárd, Novák, János, Crai, Stefan, Illés, Anita, Vincze, Áron, Molnár, Zsolt, Varga, Márta, Bod, Barnabás, Farkas, Gyula, Sümegi, János, Szepes, Attila, Dubravcsik, Zsolt, Lásztity, Natália, Párniczky, Andrea, Hamvas, József, Andorka, Csilla, Veres, Gábor, Szentkereszty, Zsolt, Rakonczay, Zoltán, Maléth, József, Sahin-Tóth, Miklós, Rosendahl, Jonas, Hegyi, Péter

“…Abstract Background Pancreatic ductal HCO3- secretion is critically dependent on the cystic fibrosis transmembrane conductance regulator chloride channel…”
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Human cationic trypsinogen (PRSS1) variants and chronic pancreatitis by Németh, Balázs Csaba, Sahin-Tóth, Miklós

“…Variations in the serine protease 1 (PRSS1) gene encoding human cationic trypsinogen have been conclusively associated with autosomal dominant hereditary…”
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Autoactivation of Mouse Trypsinogens Is Regulated by Chymotrypsin C via Cleavage of the Autolysis Loop by Németh, Balázs Csaba, Wartmann, Thomas, Halangk, Walter, Sahin-Tóth, Miklós

“…Chymotrypsin C (CTRC) is a proteolytic regulator of trypsinogen autoactivation in humans. CTRC cleavage of the trypsinogen activation peptide stimulates…”
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Novel chymotrypsin C (CTRC) variants from real-world genetic testing of pediatric chronic pancreatitis cases by Stefanovics, Regina, Sándor, Máté, Demcsák, Alexandra, Berke, Gergő, Németh, Balázs Csaba, Zhang, Wenying, Abu-El-Haija, Maisam, Sahin-Tóth, Miklós

“…Chymotrypsin C (CTRC) protects the pancreas against unwanted intrapancreatic trypsin activity through degradation of trypsinogen. Loss-of-function CTRC…”
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Risk of chronic pancreatitis in carriers of the c.180C>T (p.Gly60=) CTRC variant: case-control studies and meta-analysis by Berke, Gergő, Beer, Sebastian, Gede, Noémi, Takáts, Amanda, Szentesi, Andrea, Hegyi, Péter, Rosendahl, Jonas, Sahin-Tóth, Miklós, Németh, Balázs Csaba, Hegyi, Eszter

“…Chymotrypsin C (CTRC) is a digestive serine protease produced by the pancreas that regulates intrapancreatic trypsin activity and provides a defensive…”
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Significance of chymotrypsinogen C (CTRC) mutations c.180C>T and c.493+51C>A in Hungarian patients with chronic pancreatitis by Stefanovics, Regina, Karamya, Zain A., Sándor, Máté, Dancs, Anett, Varga, Zsófia, Hegyi, Eszter, Kun, Anasztázia Erzsébet, Vincze, Áron, Izbéki, Ferenc, Erőss, Bálint, Czakó, László, Szmola, Richárd, Boros, Eszter, Hegyi, Péter Jenő, Szentesi, Andrea, Hegyi, Péter, Németh, Balázs Csaba

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CEL-HYB1 haplotypes confer varying risk for chronic pancreatitis by Berke, Gergő, Sándor, Máté, Ewers, Maren, Erőss, Bálint, Masson, Emmanuelle, Németh, Balázs Csaba, Vincze, Áron, Czakó, László, Sahin-Tóth, Vera, Rygiel, Agnieszka Magdalena, Rosendahl, Jonas, Chen, Jian-Min, Witt, Heiko, Hegyi, Péter, Sahin-Tóth, Miklós, Hegyi, Eszter

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The degree of obesity has a serious effect on the outcome of acute pancreatitis and the development of other comorbidities: analysis of an international prospective cohort of 2244 cases by Szentesi, Andrea, Sipos, Zoltán, Farkas, Nelli, Vincze, Áron, Sarlós, Patrícia, Gódi, Szilárd, Németh, Balázs Csaba, Czakó, László, Kui, Balázs, Izbéki, Ferenc, Gajdán, László, Dunás-Varga, Veronika, Papp, Mária, Hamvas, József, Varga, Márta, Török, Imola, Novák, János, Mickevicius, Artautas, Párniczky, Andrea, Földi, Mária, Imrei, Marcell, Erőss, Bálint, Hegyi, Péter Jenő, Váncsa, Szilárd, Hegyi, Péter

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