Search Results - "Nédélec, Audrey"

Modulation of human thrombopoietin receptor conformations uncouples JAK2 V617F-driven activation from cytokine-induced stimulation by Papadopoulos, Nicolas, Pristavec, Ajda, Nédélec, Audrey, Levy, Gabriel, Staerk, Judith, Constantinescu, Stefan N.

“…•JAK2 V617F and Tpo induce dimerization of hTpoR in different dimeric conformations.•Modulation of hTpoR allows specific inhibition of JAK2 V617F–driven…”
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Noonan syndrome-causing SHP2 mutants inhibit insulin-like growth factor 1 release via growth hormone-induced ERK hyperactivation, which contributes to short stature by De Rocca Serra-Nédélec, Audrey, Edouard, Thomas, Tréguer, Karine, Tajan, Mylène, Araki, Toshiyuki, Dance, Marie, Mus, Marianne, Montagner, Alexandra, Tauber, Maïté, Salles, Jean-Pierre, Valet, Philippe, Neel, Benjamin G., Raynal, Patrick, Yart, Armelle

“…Noonan syndrome (NS), a genetic disease caused in half of cases by activating mutations of the tyrosine phosphatase SHP2 (PTPN11), is characterized by…”
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LEOPARD syndrome-associated SHP2 mutation confers leanness and protection from diet-induced obesity by Tajan, Mylène, Batut, Aurélie, Cadoudal, Thomas, Deleruyelle, Simon, Le Gonidec, Sophie, Saint Laurent, Céline, Vomscheid, Maëlle, Wanecq, Estelle, Tréguer, Karine, De Rocca Serra-Nédélec, Audrey, Vinel, Claire, Marques, Marie-Adeline, Pozzo, Joffrey, Kunduzova, Oksana, Salles, Jean-Pierre, Tauber, Maithé, Raynal, Patrick, Cavé, Hélène, Edouard, Thomas, Valet, Philippe, Yart, Armelle

“…Significance LEOPARD syndrome (multiple L entigines, E lectrocardiographic conduction abnormalities, O cular hypertelorism, P ulmonary stenosis, A bnormal…”
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Calreticulin del52 and ins5 knock-in mice recapitulate different myeloproliferative phenotypes observed in patients with MPN by Benlabiod, Camélia, Cacemiro, Maira da Costa, Nédélec, Audrey, Edmond, Valérie, Muller, Delphine, Rameau, Philippe, Touchard, Laure, Gonin, Patrick, Constantinescu, Stefan N., Raslova, Hana, Villeval, Jean-Luc, Vainchenker, William, Plo, Isabelle, Marty, Caroline

“…Somatic mutations in the calreticulin ( CALR ) gene are associated with approximately 30% of essential thrombocythemia (ET) and primary myelofibrosis (PMF)…”
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Oncogenic CALR mutant C-terminus mediates dual binding to the thrombopoietin receptor triggering complex dimerization and activation by Papadopoulos, Nicolas, Nédélec, Audrey, Derenne, Allison, Şulea, Teodor Asvadur, Pecquet, Christian, Chachoua, Ilyas, Vertenoeil, Gaëlle, Tilmant, Thomas, Petrescu, Andrei-Jose, Mazzucchelli, Gabriel, Iorga, Bogdan I., Vertommen, Didier, Constantinescu, Stefan N.

“…Calreticulin (CALR) frameshift mutations represent the second cause of myeloproliferative neoplasms (MPN). In healthy cells, CALR transiently and…”
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Functional Effects of PTPN11 (SHP2) Mutations Causing LEOPARD Syndrome on Epidermal Growth Factor-Induced Phosphoinositide 3-Kinase/AKT/Glycogen Synthase Kinase 3β Signaling by Serra-Nedelec, A., Treguer, K., Tajan, M., Araki, T., Dance, M., Mus, M., Montagner, A., Valet, P., Neel, B., Edouard, Thomas, Combier, Jean-Philippe, Nédélec, Audrey, Bel-Vialar, Sophie, Métrich, Mélanie, Conte-Auriol, Francoise, Lyonnet, Stanislas, Parfait, Béatrice, Tauber, Maithé, Salles, Jean-Pierre, Lezoualc'H, Frank, Yart, Armelle, Raynal, Patrick

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Penttinen syndrome‐associated PDGFRB Val665Ala variant causes aberrant constitutive STAT1 signalling by Nédélec, Audrey, Guérit, Emilie M., Dachy, Guillaume, Lenglez, Sandrine, Wong, Lok San, Arts, Florence A., Demoulin, Jean‐Baptiste

“…Penttinen syndrome is a rare progeroid disorder caused by mutations in platelet‐derived growth factor (PDGF) receptor beta (encoded by the PDGFRB…”
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Modulation of the Human Thrombopoietin Receptor Conformation Uncouples JAK2 V617F-Driven from Cytokine-Induced Activation by Papadopoulos, Nicolas, Pristavec, Ajda, Levy, Gabriel, Nédélec, Audrey, Staerk, Judith, Constantinescu, Stefan N.

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LEOPARD syndrome-associated SHP2 mutation confers leanness and protection from diet-induced obesity by Tajan, Mylène, Batut, Aurélie, Cadoudal, Thomas, Deleruyelle, Simon, Le Gonidec, Sophie, Laurent, Céline Saint, Vomscheid, Maëlle, Wanecq, Estelle, Tréguer, Karine, De Rocca Serra-Nédélec, Audrey, Vinel, Claire, Marques, Marie-Adeline, Pozzo, Joffrey, Kunduzova, Oksana, Salles, Jean-Pierre, Tauber, Maithé, Raynal, Patrick, Cavé, Hélène, Edouard, Thomas, Valet, Philippe, Yart, Armelle

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Hematoxylin binds to mutant calreticulin and disrupts its abnormal interaction with thrombopoietin receptor by Jia, Ruochen, Balligand, Thomas, Atamanyuk, Vasyl, Nivarthi, Harini, Xu, Erica, Kutzner, Leon, Weinzierl, Jakob, Nedelec, Audrey, Kubicek, Stefan, Lesyk, Roman, Zagrijtschuk, Oleh, Constantinescu, Stefan N., Kralovics, Robert

“…Somatic mutations of calreticulin (CALR) have been identified as a main disease driver of myeloproliferative neoplasms, suggesting that development of drugs…”
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Functional effects of PTPN11 (SHP2) mutations causing LEOPARD syndrome on epidermal growth factor-induced phosphoinositide 3-kinase/AKT/glycogen synthase kinase 3beta signaling by Edouard, Thomas, Combier, Jean-Philippe, Nédélec, Audrey, Bel-Vialar, Sophie, Métrich, Mélanie, Conte-Auriol, Francoise, Lyonnet, Stanislas, Parfait, Béatrice, Tauber, Maithé, Salles, Jean-Pierre, Lezoualc'h, Frank, Yart, Armelle, Raynal, Patrick

“…LEOPARD syndrome (LS), a disorder with multiple developmental abnormalities, is mainly due to mutations that impair the activity of the tyrosine phosphatase…”
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