Search Results - "Närvänen, Ale"

A robust approach to make inorganic nanovectors biotraceable by Wen, Huang, Närvänen, Ale, Jokivarsi, Kimmo, Poutiainen, Pekka, Xu, Wujun, Lehto, Vesa-Pekka

“…[Display omitted] Nuclear medicine imaging plays an important role in nanomedicine. However, it is still challenging to develop a versatile platform to make…”
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Smart Porous Silicon Nanoparticles with Polymeric Coatings for Sequential Combination Therapy by Xu, Wujun, Thapa, Rinez, Liu, Dongfei, Nissinen, Tuomo, Granroth, Sari, Närvänen, Ale, Suvanto, Mika, Santos, Hélder A, Lehto, Vesa-Pekka

“…In spite of the advances in drug delivery, the preparation of smart nanocomposites capable of precisely controlled release of multiple drugs for sequential…”
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Temperature responsive porous silicon nanoparticles for cancer therapy – spatiotemporal triggering through infrared and radiofrequency electromagnetic heating by Tamarov, Konstantin, Xu, Wujun, Osminkina, Liubov, Zinovyev, Sergey, Soininen, Pasi, Kudryavtsev, Andrey, Gongalsky, Maxim, Gaydarova, Azha, Närvänen, Ale, Timoshenko, Victor, Lehto, Vesa-Pekka

“…One critical functionality of the carrier system utilized in targeted drug delivery is its ability to trigger the release of the therapeutic cargo once the…”
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Biogenic nanoporous silicon carrier improves the efficacy of buparvaquone against resistant visceral leishmaniasis by Thapa, Rinez, Mondal, Subhasish, Riikonen, Joakim, Rantanen, Jimi, Näkki, Simo, Nissinen, Tuomo, Närvänen, Ale, Lehto, Vesa-Pekka

“…Visceral leishmaniasis is a vector-borne protozoan infection that is fatal if untreated. There is no vaccination against the disease, and the current…”
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Electrostatic Interaction on Loading of Therapeutic Peptide GLP‑1 into Porous Silicon Nanoparticles by Kaasalainen, Martti, Rytkönen, Jussi, Mäkilä, Ermei, Närvänen, Ale, Salonen, Jarno

“…Porous silicon (PSi) nanoparticles’ tunable properties are facilitating their use at highly challenging medical tasks such as peptide delivery. Because of many…”
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A Nanostopper Approach To Selectively Engineer the Surfaces of Mesoporous Silicon by Xu, Wujun, Rytkönen, Jussi, Rönkkö, Seppo, Nissinen, Tuomo, Kinnunen, Tuure, Suvanto, Mika, Närvänen, Ale, Lehto, Vesa-Pekka

“…Successful applications of mesoporous materials often require different surface properties of internal pore walls and external surfaces. The different…”
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The Effects of Sequence Variation on Genome-wide NRF2 Binding--New Target Genes and Regulatory SNPs by Kuosmanen, Suvi M, Viitala, Sari, Laitinen, Tuomo, Peräkylä, Mikael, Pölönen, Petri, Kansanen, Emilia, Leinonen, Hanna, Raju, Suresh, Wienecke-Baldacchino, Anke, Närvänen, Ale, Poso, Antti, Heinäniemi, Merja, Heikkinen, Sami, Levonen, Anna-Liisa

“…Transcription factor binding specificity is crucial for proper target gene regulation. Motif discovery algorithms identify the main features of the binding…”
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Proteolytic activity of prostate-specific antigen (PSA) towards protein substrates and effect of peptides stimulating PSA activity by Mattsson, Johanna M, Ravela, Suvi, Hekim, Can, Jonsson, Magnus, Malm, Johan, Närvänen, Ale, Stenman, Ulf-Håkan, Koistinen, Hannu

“…Prostate-specific antigen (PSA or kallikrein-related peptidase-3, KLK3) exerts chymotrypsin-like proteolytic activity. The main biological function of PSA is…”
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Functionalization of Alkyne-Terminated Thermally Hydrocarbonized Porous Silicon Nanoparticles With Targeting Peptides and Antifouling Polymers: Effect on the Human Plasma Protein Adsorption by Wang, Chang-Fang, Mäkilä, Ermei M, Bonduelle, Colin, Rytkönen, Jussi, Raula, Janne, Almeida, Sérgio, Närvänen, Ale, Salonen, Jarno J, Lecommandoux, Sebastien, Hirvonen, Jouni T, Santos, Hélder A

“…Porous silicon (PSi) nanomaterials combine a high drug loading capacity and tunable surface chemistry with various surface modifications to meet the…”
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Improved stability and biocompatibility of nanostructured silicon drug carrier for intravenous administration by Näkki, Simo, Rytkönen, Jussi, Nissinen, Tuomo, Florea, Cristina, Riikonen, Joakim, Ek, Paul, Zhang, Hongbo, Santos, Hélder A., Närvänen, Ale, Xu, Wujun, Lehto, Vesa-Pekka

“…[Display omitted] Nanotechnology has attracted considerable interest in the field of biomedicine, where various nanoparticles (NPs) have been introduced as…”
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Porous Silicon–Cell Penetrating Peptide Hybrid Nanocarrier for Intracellular Delivery of Oligonucleotides by Rytkönen, Jussi, Arukuusk, Piret, Xu, Wujun, Kurrikoff, Kaido, Langel, Ülo, Lehto, Vesa-Pekka, Närvänen, Ale

“…The largest obstacle to the use of oligonucleotides as therapeutic agents is the delivery of these large and negatively charged biomolecules through cell…”
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Novel systemically active galanin receptor 2 ligands in depression‐like behavior by Saar, Indrek, Lahe, Jaanus, Langel, Kent, Runesson, Johan, Webling, Kristin, Järv, Jaak, Rytkönen, Jussi, Närvänen, Ale, Bartfai, Tamas, Kurrikoff, Kaido, Langel, Ülo

“…Neuropeptide galanin and its three G‐protein coupled receptors, galanin receptor type 1–galanin receptor type 3 (GalR1–GalR3), are involved in the regulation…”
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Novel target for peptide-based imaging and treatment of brain tumors by Hyvönen, Maija, Enbäck, Juulia, Huhtala, Tuulia, Lammi, Johanna, Sihto, Harri, Weisell, Janne, Joensuu, Heikki, Rosenthal-Aizman, Katri, El-Andaloussi, Samir, Langel, Ulo, Närvänen, Ale, Bergers, Gabriele, Laakkonen, Pirjo

“…Malignant gliomas are associated with high mortality due to infiltrative growth, recurrence, and malignant progression. Even with the most efficient therapy…”
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Development of molecules stimulating the activity of KLK3 - an update by Koistinen, Hannu, Wallén, Erik, Ylikangas, Henna, Meinander, Kristian, Lahtela-Kakkonen, Maija, Närvänen, Ale, Stenman, Ulf-Håkan

“…Kallikrein-related peptidase-3 (KLK3, known also as prostate-specific antigen, PSA) is highly expressed in the prostate. KLK3 possess antiangiogenic activity,…”
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Firefly Luciferase Inhibitor-Conjugated Peptide Quenches Bioluminescence: A Versatile Tool for Real Time Monitoring Cellular Uptake of Biomolecules by Poutiainen, Pekka K, Rönkkö, Teemu, Hinkkanen, Ari E, Palvimo, Jorma J, Närvänen, Ale, Turhanen, Petri, Laatikainen, Reino, Weisell, Janne, Pulkkinen, Juha T

“…In this paper, novel firefly luciferase-specific inhibitor compounds (FLICs) are evaluated as potential tools for cellular trafficking of transporter…”
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The SPECT imaging shows the accumulation of neural progenitor cells into internal organs after systemic administration in middle cerebral artery occlusion rats by Lappalainen, Riikka S., Narkilahti, Susanna, Huhtala, Tuulia, Liimatainen, Timo, Suuronen, Tiina, Närvänen, Ale, Suuronen, Riitta, Hovatta, Outi, Jolkkonen, Jukka

“…The regenerative potential of stem cells from various sources has been under intense investigation in the experimental models of cerebral ischemia. To end up…”
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Replacement of the Disulfide Bridge in a KLK3-Stimulating Peptide Using Orthogonally Protected Building Blocks by Meinander, Kristian, Pakkala, Miikka, Weisell, Janne, Stenman, Ulf-Håkan, Koistinen, Hannu, Närvänen, Ale, Wallén, Erik A. A

“…Peptide “B-2”, which is one of the most potent kallikrein-related peptidase 3 (KLK3)-stimulating compounds, consists of 12 amino acids and is cyclized by a…”
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Peptides binding to prostate-specific antigen enhance its antiangiogenic activity by Mattsson, Johanna M., Närvänen, Ale, Stenman, Ulf-Håkan, Koistinen, Hannu

“…BACKGROUND Proteolytically active prostate‐specific antigen (PSA or kallikrein‐related peptidase 3, KLK3) has been shown to exert antiangiogenic properties…”
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Human umbilical cord blood cells do not improve sensorimotor or cognitive outcome following transient middle cerebral artery occlusion in rats by Mäkinen, Susanna, Kekarainen, Tuija, Nystedt, Johanna, Liimatainen, Timo, Huhtala, Tuulia, Närvänen, Ale, Laine, Jarmo, Jolkkonen, Jukka

“…The present study investigated effects of human umbilical cord blood (HUCB) cells on sensorimotor, cognitive, and histological outcome in rats subjected to…”
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Allergen-specific naïve and memory CD4⁺ T cells exhibit functional and phenotypic differences between individuals with or without allergy by Kinnunen, Tuure, Nieminen, Anssi, Kwok, William W, Närvänen, Ale, Rytkönen-Nissinen, Marja, Saarelainen, Soili, Taivainen, Antti, Virtanen, Tuomas

“…Although allergen-specific CD4⁺ T cells are detectable in the peripheral blood of both individuals with or without allergy, their frequencies and phenotypes…”
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