Search Results - "Nürnberg, Bernd"

The Transforming Acidic Coiled Coil 3 Protein Is Essential for Spindle-dependent Chromosome Alignment and Mitotic Survival by Schneider, Leonid, Essmann, Frank, Kletke, Anja, Rio, Paula, Hanenberg, Helmut, Wetzel, Wiebke, Schulze-Osthoff, Klaus, Nürnberg, Bernd, Piekorz, Roland P.

“…Cancer-associated centrosomal transforming acidic coiled coil (TACC) proteins are involved in mitotic spindle function. By employing gene targeting, we have…”
Get full text

Correction: Gα i2 - and Gα i3 -Specific Regulation of Voltage-Dependent L-Type Calcium Channels in Cardiomyocytes by Dizayee, Sara, Kaestner, Sonja, Kuck, Fabian, Hein, Peter, Klein, Christoph, Piekorz, Roland P., Meszaros, Janos, Matthes, Jan, Nürnberg, Bernd, Herzig, Stefan

“…Laboratory of Neurobiology, National Institutes of Health, 111 TW Alexander Drive, North Carolina, United States of America Additional Funding information for…”
Get full text

Rho GTPases and Phosphoinositide 3-Kinase Organize Formation of Branched Dendrites by Leemhuis, Jost, Boutillier, Stephanie, Barth, Holger, Feuerstein, Thomas J., Brock, Carsten, Nürnberg, Bernd, Aktories, Klaus, Meyer, Dieter K.

“…Neurons receive information from other neurons via their dendritic tree. Dendrites and their branches result from alternating outgrowth and retraction. The Rho…”
Get full text

Ras is an indispensable coregulator of the class IB phosphoinositide 3-kinase p87/p110Πby Kurig, Barbara, Shymanets, Aliaksei, Bohnacker, Thomas, Prajwal, Brock, Carsten, Ahmadian, Mohammad Reza, Schaefer, Michael, Gohla, Antje, Harteneck, Christian, Wymann, Matthias P, Jeanclos, Elisabeth, Nürnberg, Bernd

“…Class IB phosphoinositide 3-kinase γ (PI3Kγ) elicits various immunologic and cardiovascular responses; however, the molecular basis for this signal…”
Get full text

Phosphoinositide 3-Kinases γ and δ, Linkers of Coordinate C5a Receptor-Fcγ Receptor Activation and Immune Complex-induced Inflammation by Stephanie Konrad, Syed R. Ali, Kristina Wiege, Shahzad N. Syed, Linda Engling, Roland P. Piekorz, Emilio Hirsch, Bernd Nürnberg, Reinhold E. Schmidt, J. Engelbert Gessner

“…Fcγ receptors (FcγR) and the C5a receptor (C5aR) are key effectors of the acute inflammatory response to IgG immune complexes (IC). Their coordinated…”
Get full text

S100A1 Enhances the L-type Ca2+ Current in Embryonic Mouse and Neonatal Rat Ventricular Cardiomyocytes by Reppel, Michael, Sasse, Philipp, Piekorz, Roland, Tang, Ming, Roell, Wilhelm, Duan, Yaqi, Kletke, Anja, Hescheler, Jürgen, Nürnberg, Bernd, Fleischmann, Bernd K.

“…S100A1 is an EF-hand type Ca2+-binding protein with a muscle-specific expression pattern. The highest S100A1 protein levels are found in cardiomyocytes, and it…”
Get full text

Assigning Functional Domains within the p101 Regulatory Subunit of Phosphoinositide 3-Kinase Πby Philipp Voigt, Carsten Brock, Bernd Nürnberg, Michael Schaefer

“…Phosphoinositide 3-Kinase (PI3K) γ is a lipid kinase that is regulated by G-protein-coupled receptors. It plays a crucial role in inflammatory and allergic…”
Get full text

Specificity and Structural Requirements of Phospholipase C-β Stimulation by Rho GTPases Versus G Protein βγ Dimers by Daria Illenberger, Claudia Walliser, Bernd Nürnberg, Maria Diaz Lorente, Peter Gierschik

“…Phospholipase C-β 2 (PLCβ 2 ) is activated both by heterotrimeric G protein α- and βγ- subunits and by Rho GTPases. In this study, activated Rho GTPases…”
Get full text

Activation and inhibition of G proteins by lipoamines by Breitweg-Lehmann, Evelyn, Czupalla, Cornelia, Storm, Rüdiger, Kudlacek, Oliver, Schunack, Walter, Freissmuth, Michael, Nürnberg, Bernd

“…We have previously shown that alkyl-substituted amino acid derivatives directly activate G(i/o) proteins…”
Get more information

Roles of Non-catalytic Subunits in Gβγ-induced Activation of Class I Phosphoinositide 3-Kinase Isoforms β and Πby Udo Maier, Aleksei Babich, Bernd Nürnberg

“…By using purified preparations we show that nanomolar concentrations of Gβγ significantly stimulated lipid kinase activity of phosphatidylinositol 3-kinase…”
Get full text

Identification and Characterization of the Autophosphorylation Sites of Phosphoinositide 3-Kinase Isoforms β and Πby Cornelia Czupalla, Miran Culo, Eva-Christina Müller, Carsten Brock, H. Peter Reusch, Karsten Spicher, Eberhard Krause, Bernd Nürnberg

“…Class I phosphoinositide 3-kinases (PI3Ks) are bifunctional enzymes possessing lipid kinase activity and the capacity to phosphorylate their catalytic and/or…”
Get full text

Phosphoinositide 3-Kinase γ Mediates Angiotensin II-induced Stimulation of L-type Calcium Channels in Vascular Myocytes by Jean-François Quignard, Jean Mironneau, Valérie Carricaburu, Bernard Fournier, Aleksei Babich, Bernd Nürnberg, Chantal Mironneau, Nathalie Macrez

“…Previous results have shown that in rat portal vein myocytes the βγ dimer of the G 13 protein transduces the angiotensin II-induced stimulation of calcium…”
Get full text

Gβ5γ2 Is a Highly Selective Activator of Phospholipid-dependent Enzymes by Udo Maier, Aleksei Babich, Nathalie Macrez, Daniela Leopoldt, Peter Gierschik, Daria Illenberger, Bernd Nürnberg

“…In this study, Gβ specificity in the regulation of Gβγ-sensitive phosphoinositide 3-kinases (PI3Ks) and phospholipase Cβ (PLCβ) isozymes was examined…”
Get full text

Activation of Go-proteins by Membrane Depolarization Traced by in Situ Photoaffinity Labeling of Gαo-proteins with [α32P]GTP-azidoanilide by Yosef Anis, Bernd Nürnberg, Leonid Visochek, Nachum Reiss, Zvi Naor, Malka Cohen-Armon

“…Evidence for depolarization-induced activation of G-proteins in membranes of rat brain synaptoneurosomes has been previously reported (Cohen-Armon, M., and…”
Get full text

Cyclic GMP-dependent Protein Kinase Blocks Pertussis Toxin-sensitive Hormone Receptor Signaling Pathways in Chinese Hamster Ovary Cells by Pfeifer, Alexander, Nürnberg, Bernd, Kamm, Simone, Uhde, Martina, Schultz, Günter, Ruth, Peter, Hofmann, Franz

“…cGMP-dependent protein kinase (cGMP kinase) has been implicated in the regulation of the cytosolic calcium level ([Ca ] ). In Chinese hamster ovary (CHO) cells…”
Get full text

Gβγ Stimulates Phosphoinositide 3-Kinase-γ by Direct Interaction with Two Domains of the Catalytic p110 Subunit by Daniela Leopoldt, Theodor Hanck, Torsten Exner, Udo Maier, Reinhard Wetzker, Bernd Nürnberg

“…Class I phosphoinositide 3-kinases (PI3Ks) regulate important cellular processes such as mitogenesis, apoptosis, and cytoskeletal functions. They include…”
Get full text

Tyrosine Phosphorylation of Gsα and Inhibition of Bradykinin-induced Activation of the Cyclic AMP Pathway in A431 Cells by Epidermal Growth Factor Receptor by Claus Liebmann, Angela GraneÃ, Annette Boehmer, Marina Kovalenko, Antje Adomeit, Torsten Steinmetzer, Bernd Nürnberg, Reinhard Wetzker, Frank-D. Boehmer

“…An increasing amount of experimental data suggest that cross-talk exists between pathways involving tyrosine kinases and heterotrimeric G proteins. In a…”
Get full text

A Heterotrimeric G Protein of the Gi Family Is Required for cAMP-triggered Trafficking of Aquaporin 2 in Kidney Epithelial Cells by Valenti, Giovanna, Procino, Giuseppe, Liebenhoff, Ursula, Frigeri, Antonio, Benedetti, Pio Alberto, Ahnert-Hilger, Gudrun, Nürnberg, Bernd, Svelto, Maria, Rosenthal, Walter

“…Vasopressin is the key regulator of water homeostasis in vertebrates. Central to its antidiuretic action in mammals is the redistribution of the water channel…”
Get full text

A Putative Heterotrimeric G Protein Inhibits the Fusion of COPI-coated Vesicles by Helms, J. Bernd, Helms-Brons, Désiré, Brügger, Britta, Gkantiragas, Ioannis, Eberle, Heike, Nickel, Walter, Nürnberg, Bernd, Gerdes, Hans-Hermann, Wieland, Felix T.

“…Heterotrimeric G proteins have been implicated in the regulation of intracellular protein transport, but their mechanism of action remains unclear. In vivo ,…”
Get full text