Search Results - "N, Blaney"

A roadmap to target interleukin-6 in osteoarthritis by Wiegertjes, Renske, van de Loo, Fons A J, Blaney Davidson, Esmeralda N

“…Abstract Joint inflammation is present in the majority of OA patients and pro-inflammatory mediators, such as IL-6, are actively involved in disease…”
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Unravelling osteoarthritis-related synovial fibrosis: a step closer to solving joint stiffness by Remst, Dennis F G, Blaney Davidson, Esmeralda N, van der Kraan, Peter M

“…Synovial fibrosis is often found in OA, contributing heavily to joint pain and joint stiffness, the main symptoms of OA. At this moment the underlying…”
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Comparison of diagnostic accuracy in sepsis between presepsin, procalcitonin, and C-reactive protein: a systematic review and meta-analysis by Wu, Chin-Chieh, Lan, Hao-Min, Han, Shih-Tsung, Chaou, Chung-Hsien, Yeh, Chun-Fu, Liu, Su-Hsun, Li, Chih-Huang, Blaney, Gerald N., Liu, Zhen-Ying, Chen, Kuan-Fu

“…Background The soluble cluster of differentiation 14 (or presepsin) is a free fragment of glycoprotein expressed on monocytes and macrophages. Although many…”
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Increase in ALK1/ALK5 Ratio as a Cause for Elevated MMP-13 Expression in Osteoarthritis in Humans and Mice by Blaney Davidson, Esmeralda N, Remst, Dennis F. G, Vitters, Elly L, van Beuningen, Henk M, Blom, Arjen B, Goumans, Marie-Jose, van den Berg, Wim B, van der Kraan, Peter M

“…During osteoarthritis (OA) chondrocytes show deviant behavior resembling terminal differentiation of growth-plate chondrocytes, characterized by elevated…”
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TGF-beta signaling in chondrocyte terminal differentiation and osteoarthritis: modulation and integration of signaling pathways through receptor-Smads by van der Kraan, P M, Blaney Davidson, E N, Blom, A, van den Berg, W B

“…Chondrocytes and alteration in chondrocyte differentiation play a central role in osteoarthritis. Chondrocyte differentiation is amongst others regulated by…”
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Association of In-Hospital Mortality and Dysglycemia in Septic Patients by Chao, Hsiao-Yun, Liu, Peng-Hui, Lin, Shen-Che, Chen, Chun-Kuei, Chen, Jih-Chang, Chan, Yi-Lin, Wu, Chin-Chieh, Blaney, Gerald N, Liu, Zhen-Ying, Wu, Cho-Ju, Chen, Kuan-Fu

“…The associations between dysglycemia and mortality in septic patients with and without diabetes are yet to be confirmed. Our aim was to analyze the association…”
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Sclerostin antibody enhances implant osseointegration in bone with Col1a1 mutation by Sung, Hsiao H., Kwon, Hanna H., Stephan, Chris, Reynolds, Skylar M., Dai, Zongrui, Van der Kraan, Peter M., Caird, Michelle S., Blaney Davidson, Esmeralda N., Kozloff, Kenneth M.

“…We evaluated the potential of sclerostin antibody (SclAb) therapy to enhance osseointegration of dental and orthopaedic implants in a mouse model (Brtl/+)…”
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The alarmins S100A8 and S100A9 mediate acute pain in experimental synovitis by Blom, Arjen B, van den Bosch, Martijn H, Blaney Davidson, Esmeralda N, Roth, Johannes, Vogl, Thomas, van de Loo, Fons A, Koenders, Marije, van der Kraan, Peter M, Geven, Edwin J, van Lent, Peter L

“…Synovitis-associated pain is mediated by inflammatory factors that may include S100A8/9, which is able to stimulate nociceptive neurons via Toll-like receptor…”
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Gene Expression Analysis of Murine and Human Osteoarthritis Synovium Reveals Elevation of Transforming Growth Factor β–Responsive Genes in Osteoarthritis‐Related Fibrosis by Remst, D. F. G., Blom, A. B., Vitters, E. L., Bank, R. A., Berg, W. B., Blaney Davidson, E. N., Kraan, P. M.

“…Objective Synovial fibrosis is a major contributor to joint stiffness in osteoarthritis (OA). Transforming growth factor β (TGFβ), which is elevated in OA,…”
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Sex Differences in Pain Sensitivity in a Dutch Cohort: Cross-Sectional and Web-Based Multidimensional Study by Smits, Rachel J H, van der Wal, Selina E I, van Boekel, Regina L M, Timmerman, Hans, Bronkhorst, Ewald M, Abrar, Diana, Vissers, Kris C P, Blaney Davidson, Esmeralda N, Steegers, Monique A H

“…Sex is an important factor influencing the development and treatment of chronic pain, but the extent of its influence is still unclear. Other demographic…”
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Ageing is associated with reduction of mechanically-induced activation of Smad2/3P signaling in articular cartilage by Madej, W, van Caam, A, Blaney Davidson, E.N, Hannink, G, Buma, P, van der Kraan, P.M

“…Summary Objective Mechanical signals control key cellular processes in articular cartilage. Previously we have shown that mechanical compression is an…”
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Expression of transforming growth factor-β (TGFβ) and the TGFβ signalling molecule SMAD-2P in spontaneous and instability-induced osteoarthritis: role in cartilage degradation, chondrogenesis and osteophyte formation by Blaney Davidson, E N, Vitters, E L, van der Kraan, P M, van den Berg, W B

“…Background: The primary feature of osteoarthritis is cartilage loss. In addition, osteophytes can frequently be observed. Transforming growth factor-β (TGFβ)…”
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Inducible chondrocyte-specific overexpression of BMP2 in young mice results in severe aggravation of osteophyte formation in experimental OA without altering cartilage damage by Blaney Davidson, E N, Vitters, E L, Bennink, M B, van Lent, P L E M, van Caam, A P M, Blom, A B, van den Berg, W B, van de Loo, F A J, van der Kraan, P M

“…In osteoarthritis (OA) chondrocytes surrounding lesions express elevated bone morphogenetic protein 2 (BMP2) levels. To investigate the functional consequence…”
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Osteoarthritis year in review 2016: biology by Blaney Davidson, E.N, van Caam, A.P.M, van der Kraan, P.M

“…Summary This review highlights a selection of literature in the area of osteoarthritis biology published between the 2015 and 2016 Osteoarthritis Research…”
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The number of displaced rib fractures is more predictive for complications in chest trauma patients by Chien, Chih-Ying, Chen, Yu-Hsien, Han, Shih-Tsung, Blaney, Gerald N, Huang, Ting-Shuo, Chen, Kuan-Fu

“…Inneholder sammendrag…”
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TGF-β and osteoarthritis by Blaney Davidson, E.N., M.Sc, van der Kraan, P.M., Ph.D, van den Berg, W.B., Ph.D

“…Summary Objective Cartilage damage is a major problem in osteoarthritis (OA). Growth factors like transforming growth factor-β (TGF-β) have great potential in…”
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Smad signaling determines chondrogenic differentiation of bone-marrow-derived mesenchymal stem cells: inhibition of Smad1/5/8P prevents terminal differentiation and calcification by Hellingman, Catharine A, Davidson, Esmeralda N Blaney, Koevoet, Wendy, Vitters, Elly L, van den Berg, Wim B, van Osch, Gerjo J V M, van der Kraan, Peter M

“…The aim of this study was to investigate the roles of Smad2/3 and Smad1/5/8 phosphorylation in transforming growth factor-beta-induced chondrogenic…”
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Activin Receptor-Like Kinase Receptors ALK5 and ALK1 Are Both Required for TGFβ-Induced Chondrogenic Differentiation of Human Bone Marrow-Derived Mesenchymal Stem Cells by de Kroon, Laurie M G, Narcisi, Roberto, Blaney Davidson, Esmeralda N, Cleary, Mairéad A, van Beuningen, Henk M, Koevoet, Wendy J L M, van Osch, Gerjo J V M, van der Kraan, Peter M

“…Bone marrow-derived mesenchymal stem cells (BMSCs) are promising for cartilage regeneration because BMSCs can differentiate into cartilage tissue-producing…”
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Separating friend from foe: Inhibition of TGF-β-induced detrimental SMAD1/5/9 phosphorylation while maintaining protective SMAD2/3 signaling in OA chondrocytes by Thielen, Nathalie G.M., van Caam, Arjan P.M., v. Beuningen, Henk M., Vitters, Elly L., van den Bosch, Martijn H.J., Koenders, Marije I., van de Loo, Fons A.J., Blaney Davidson, Esmeralda N., van der Kraan, Peter M.

“…Transforming growth factor-β (TGF-β) signaling via SMAD2/3 is crucial to control cartilage homeostasis. However, TGF-β can also have detrimental effects by…”
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SMAD3 and SMAD4 have a more dominant role than SMAD2 in TGFβ-induced chondrogenic differentiation of bone marrow-derived mesenchymal stem cells by de Kroon, Laurie M. G., Narcisi, Roberto, van den Akker, Guus G. H., Vitters, Elly L., Blaney Davidson, Esmeralda N., van Osch, Gerjo J. V. M., van der Kraan, Peter M.

“…To improve cartilage formation by bone marrow-derived mesenchymal stem cells (BMSCs), the signaling mechanism governing chondrogenic differentiation requires…”
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