Search Results - "N'KULI, Francisca"
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Lysosome-Dependent Activation of Human Dendritic Cells by the Vaccine Adjuvant QS-21
Published in Frontiers in immunology (05-01-2017)“…The adjuvant properties of the saponin QS-21 have been known for decades. It is a component of the Adjuvant System AS01 that is used in several vaccine…”
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Endogenous sphingomyelin segregates into submicrometric domains in the living erythrocyte membrane[S]
Published in Journal of lipid research (01-07-2014)“…We recently reported that trace insertion of exogenous fluorescent (green BODIPY) analogs of sphingomyelin (SM) into living red blood cells (RBCs), partially…”
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Time Course of Pathogenic and Adaptation Mechanisms in Cystinotic Mouse Kidneys
Published in Journal of the American Society of Nephrology (01-06-2014)“…Cystinosis, a main cause of Fanconi syndrome, is reproduced in congenic C57BL/6 cystinosin knockout (KO) mice. To identify the sequence of pathogenic and…”
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Regulation of macrophage motility by the water channel aquaporin-1: crucial role of M0/M2 phenotype switch
Published in PloS one (26-02-2015)“…The water channel aquaporin-1 (AQP1) promotes migration of many cell types. Although AQP1 is expressed in macrophages, its potential role in macrophage…”
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Amyloid precursor protein controls cholesterol turnover needed for neuronal activity
Published in EMBO molecular medicine (01-04-2013)“…Perturbation of lipid metabolism favours progression of Alzheimer disease, in which processing of Amyloid Precursor Protein (APP) has important implications…”
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Vps34/PI3KC3 deletion in kidney proximal tubules impairs apical trafficking and blocks autophagic flux, causing a Fanconi-like syndrome and renal insufficiency
Published in Scientific reports (20-09-2018)“…Kidney proximal tubular cells (PTCs) are highly specialized for ultrafiltrate reabsorption and serve as paradigm of apical epithelial differentiation…”
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Syndecan recyling is controlled by syntenin-PIP2 interaction and Arf6
Published in Developmental cell (01-09-2005)Get full text
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Receptor-mediated endocytosis of phosphodiester oligonucleotides in the HepG2 cell line: evidence for non-conventional intracellular trafficking
Published in Nucleic acids research (01-04-2002)“…Having identified an oligonucleotide (ON) receptor in the HepG2 cell line, we have re-examined here the kinetics of ON uptake, subcellular distribution and…”
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Lysosome-Dependent Activation of Human Dendritic Cells by the Vaccine Adjuvant QS-21
Published in Frontiers in immunology (05-01-2017)Get full text
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10
Identification, purification and partial characterisation of an oligonucleotide receptor in membranes of HepG2 cells
Published in Nucleic acids research (15-02-2000)“…The low and unpredictable uptake and cytosolic transfer of oligonucleotides (ODN) is a major reason for their limited benefit. Improving the ODN potential for…”
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Infection by Mycoplasma hyorhinis strongly enhances uptake of antisense oligonucleotides: a reassessment of receptor‐mediated endocytosis in the HepG2 cell line
Published in Nucleic acids research (01-02-2003)“…This paper shows that the ∼66 kDa band, previously isolated from the HepG2 cell line as an oligonucleotide (ON) plasma membrane ‘receptor’, is induced by…”
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A Unique C‐terminal Domain Allows Retention of Matrix Metalloproteinase‐27 in the Endoplasmic Reticulum
Published in Traffic (Copenhagen, Denmark) (01-04-2014)“…We report that, unlike other matrix metalloproteinases (MMPs), MMP‐27 is retained in the endoplasmic reticulum due to its specific C‐terminal extension (CTE)…”
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ZONAB Promotes Proliferation and Represses Differentiation of Proximal Tubule Epithelial Cells
Published in Journal of the American Society of Nephrology (01-03-2010)“…Epithelial polarization modulates gene expression. The transcription factor zonula occludens 1 (ZO-1)-associated nucleic acid binding protein (ZONAB) can…”
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In vitro correction of disorders of lysosomal transport by microvesicles derived from baculovirus-infected Spodoptera cells
Published in Molecular genetics and metabolism (01-05-2013)“…Infection of Spodoptera frugiperda (Sf9) cells by baculovirus (BV) is well established for transgene expression of soluble proteins, but few correctly folded…”
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Class III Phosphoinositide 3‐Kinase/VPS34 and Dynamin are Critical for Apical Endocytic Recycling
Published in Traffic (Copenhagen, Denmark) (01-08-2013)“…Synopsis Recycling is a limiting step for receptor‐mediated endocytosis. We here show that class III PI3K is the key isoform involved, based on differential…”
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Lithium Chloride Increases the Production of Amyloid-β Peptide Independently from Its Inhibition of Glycogen Synthase Kinase 3
Published in The Journal of biological chemistry (30-09-2005)“…Glycogen synthase kinase 3 (GSK3) is able to phosphorylate tau at many sites that are found to be phosphorylated in paired helical filaments in Alzheimer…”
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P4‐036: Amyloid precursor protein regulates neuronal cholesterol turnover needed for synaptic activity
Published in Alzheimer's & dementia (01-07-2012)Get full text
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Amyloid precursor protein regulates neuronal cholesterol turnover needed for synaptic activity
Published in Alzheimer's & dementia (01-07-2012)Get full text
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Lactacystin decreases amyloid-β peptide production by inhibiting β-secretase activity
Published in Journal of neuroscience research (01-11-2006)“…The human amyloid precursor protein (APP) is processed by the nonamyloidogenic and the amyloidogenic catabolic pathways. The sequential cleavage of APP by the…”
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Lithium Chloride Increases the Production of Amyloid-β Peptide Independently from Its Inhibition of Glycogen Synthase Kinase 3
Published in The Journal of biological chemistry (30-09-2005)“…Glycogen synthase kinase 3 (GSK3) is able to phosphorylate tau at many sites that are found to be phosphorylated in paired helical filaments in Alzheimer…”
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