Search Results - "Mzik, M."

UHPLC-HRMS study of pharmacokinetics of a novel hybrid cholinesterase inhibitor K1234: A comparison between in silico, in vitro and in vivo data by Mzik, M., Sestak, V., Mezeiova, E., Korabecny, J., Hroch, M., Pejchal, J., Karasova-Zdarova, J.

“…Alzheimer's disease (AD) is one of the most common forms of dementia. Current anti-AD therapeutics exploit the cholinergic hypothesis of its pathophysiology;…”
Get full text

UHPLC-HRMS study of anti-Alzheimer’s drug candidates: metabolism of 7-MEOTA-tryptophan hybrids hampers their passage into brain by Mžik, M., Žďárová-Karasová, J., Chalupová, K., Korábečný, J, Palička, V., Šesták, V.

“…•Potent multitarget anti-Alzheimer’s compounds – S-K1025 and S-K1026 – fail to enter the brain in rats.•These compounds are prone to metabolism both in vitro…”
Get full text

Importance of Tumour Suppressor Gene Methylation in Sinonasal Carcinomas by Chmelařová, M, Sirák, I, Mžik, M, Sieglová, K, Vošmiková, H, Dundr, P, Němejcová, K, Michálek, J, Vošmik, M, Palička, V, Laco, J

“…Epigenetic changes are considered to be a frequent event during tumour development. Hypermethylation of promoter CpG islands represents an alternative…”
Get full text

Promoter methylation of GATA4, WIF1, NTRK1 and other selected tumour suppressor genes in ovarian cancer by Chmelařová, M, Dvořáková, E, Špaček, J, Laco, J, Mžik, M, Palička, V

“…Ovarian cancer is the leading cause of death from gynaecologic tumours, but the molecular and especially epigenetic events underlying the transformation are…”
Get full text

1-Benzyl-4-methylpiperidinyl moiety in donepezil: The priority ticket across the blood-brain-barrier in rats by Zdarova Karasova, Jana, Sestak, Vit, Korabecny, Jan, Mezeiova, Eva, Palicka, Vladimir, Kuca, Kamil, Mzik, Martin

“…•We present a validated UHPLC-HRMS method used for pharmacokinetic analysis of donepezil and its three structural “fragments”.•One of the fragments accumulates…”
Get full text