Search Results - "Myung Shik Lee"

GDF15 as a central mediator for integrated stress response and a promising therapeutic molecule for metabolic disorders and NASH by Kim, Kook Hwan, Lee, Myung-Shik

“…Mitochondria is a key organelle for energy production and cellular adaptive response to intracellular and extracellular stresses. Mitochondrial stress can be…”
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Mitochondria and the NLRP3 inflammasome: physiological and pathological relevance by Yu, Je-Wook, Lee, Myung-Shik

“…The NLRP3 inflammasome is assembled and activated in certain types of myeloid cells upon sensing microbe-derived toxins or host-derived danger signals…”
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New mechanisms of metformin action: Focusing on mitochondria and the gut by Hur, Kyu Yeon, Lee, Myung-Shik

“…The most well‐known mechanism of metformin action, one of the most commonly prescribed antidiabetic drugs, is adenosine monophosphate‐activated protein kinase…”
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Gut Microbiota and Metabolic Disorders by Hur, Kyu Yeon, Lee, Myung-Shik

“…Gut microbiota plays critical physiological roles in the energy extraction and in the control of local or systemic immunity. Gut microbiota and its disturbance…”
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SGLT2 inhibition modulates NLRP3 inflammasome activity via ketones and insulin in diabetes with cardiovascular disease by Kim, So Ra, Lee, Sang-Guk, Kim, Soo Hyun, Kim, Jin Hee, Choi, Eunhye, Cho, Wonhee, Rim, John Hoon, Hwang, Inhwa, Lee, Chan Joo, Lee, Minyoung, Oh, Chang-Myung, Jeon, Justin Y., Gee, Heon Yung, Kim, Jeong-Ho, Lee, Byung-Wan, Kang, Eun Seok, Cha, Bong-Soo, Lee, Myung-Shik, Yu, Je-Wook, Cho, Jin Won, Kim, Jung-Sun, Lee, Yong-ho

“…Sodium–glucose cotransporter 2 (SGLT2) inhibitors reduce cardiovascular events in humans with type 2 diabetes (T2D); however, the underlying mechanism remains…”
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Phosphorylation of p62 Activates the Keap1-Nrf2 Pathway during Selective Autophagy by Ichimura, Yoshinobu, Waguri, Satoshi, Sou, Yu-shin, Kageyama, Shun, Hasegawa, Jun, Ishimura, Ryosuke, Saito, Tetsuya, Yang, Yinjie, Kouno, Tsuguka, Fukutomi, Toshiaki, Hoshii, Takayuki, Hirao, Atsushi, Takagi, Kenji, Mizushima, Tsunehiro, Motohashi, Hozumi, Lee, Myung-Shik, Yoshimori, Tamotsu, Tanaka, Keiji, Yamamoto, Masayuki, Komatsu, Masaaki

“…The Keap1-Nrf2 system and autophagy are both involved in the oxidative-stress response, metabolic pathways, and innate immunity, and dysregulation of these…”
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Role of β‐cell autophagy in β‐cell physiology and the development of diabetes by Yasasilka, Xaviera Riani, Lee, Myung‐Shik

“…Elucidating the molecular mechanism of autophagy was a landmark in understanding not only the physiology of cells and tissues, but also the pathogenesis of…”
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Effect of mitochondrial stress on systemic metabolism by Lee, Myung-Shik

“…In our studies investigating the role of autophagy in systemic metabolism, we found that mitochondrial dysfunction due to autophagy deficiency in insulin…”
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Pathogenesis of Nonalcoholic Steatohepatitis and Hormone-Based Therapeutic Approaches by Kim, Kook Hwan, Lee, Myung-Shik

“…Non-alcoholic fatty liver disease (NAFLD) is an emerging global health problem and a potential risk factor for type 2 diabetes, cardiovascular disease, and…”
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FGF21 as a mediator of adaptive responses to stress and metabolic benefits of anti-diabetic drugs by Kim, Kook Hwan, Lee, Myung-Shik

“…Most hormones secreted from specific organs of the body in response to diverse stimuli contribute to the homeostasis of the whole organism. Fibroblast growth…”
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Role of mitochondrial function in cell death and body metabolism by Lee, Myung-Shik

“…Mitochondria are the key players in apoptosis and necrosis. Mitochondrial DNA (mtDNA)-depleted r0 cells were resistant to diverse apoptosis inducers such as…”
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A GLP‐1/GLP‐2 receptor dual agonist to treat NASH: Targeting the gut‐liver axis and microbiome by Kim, Eun Ran, Park, Jeong Su, Kim, Jin Hee, Oh, Ji Young, Oh, In Jeong, Choi, Da Hyun, Lee, Yu seol, Park, I. Seul, Kim, SeungWon, Lee, Da Hyun, Cheon, Jae Hee, Bae, Jin‐Woo, Lee, Minyoung, Cho, Jin Won, An, In Bok, Nam, Eun Joo, Yang, Sang‐In, Lee, Myung‐Shik, Bae, Soo Han, Lee, Yong‐ho

“…Background and Aims Currently there is no Food and Drug Administration–approved drug to treat NAFLD and NASH, the rates of which are increasing worldwide…”
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Autophagy induction can regulate skin pigmentation by causing melanosome degradation in keratinocytes and melanocytes by Kim, Ji Young, Kim, Jihee, Ahn, Yuri, Lee, Eun Jung, Hwang, Shinwon, Almurayshid, Abdurrahman, Park, Keedon, Chung, Hwa‐Jee, Kim, Heung Jae, Lee, Si‐Hyung, Lee, Myung‐Shik, Oh, Sang Ho

“…Autophagy regulates cellular turnover by disassembling unnecessary or dysfunctional constituents. Recent studies demonstrated that autophagy and its regulators…”
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Persistent activation of Nrf2 through p62 in hepatocellular carcinoma cells by Inami, Yoshihiro, Waguri, Satoshi, Sakamoto, Ayako, Kouno, Tsuguka, Nakada, Kazuto, Hino, Okio, Watanabe, Sumio, Ando, Jin, Iwadate, Manabu, Yamamoto, Masayuki, Lee, Myung-Shik, Tanaka, Keiji, Komatsu, Masaaki

“…Suppression of autophagy is always accompanied by marked accumulation of p62, a selective autophagy substrate. Because p62 interacts with the Nrf2-binding site…”
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β-cell autophagy: Mechanism and role in β-cell dysfunction by Lee, Yong-ho, Kim, Jinyoung, Park, Kihyoun, Lee, Myung-Shik

“…Elucidation of the basic molecular mechanism of autophagy was a breakthrough in understanding various physiological events and pathogenesis of diverse…”
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A novel autophagy enhancer as a therapeutic agent against metabolic syndrome and diabetes by Lim, Hyejin, Lim, Yu-Mi, Kim, Kook Hwan, Jeon, Young Eui, Park, Kihyoun, Kim, Jinyoung, Hwang, Hui-Yun, Lee, Dong Jin, Pagire, Haushabhau, Kwon, Ho Jeong, Ahn, Jin Hee, Lee, Myung-Shik

“…Autophagy is a critical regulator of cellular homeostasis, dysregulation of which is associated with diverse diseases. Here we show therapeutic effects of a…”
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p62/Sqstm1 promotes malignancy of HCV-positive hepatocellular carcinoma through Nrf2-dependent metabolic reprogramming by Saito, Tetsuya, Ichimura, Yoshinobu, Taguchi, Keiko, Suzuki, Takafumi, Mizushima, Tsunehiro, Takagi, Kenji, Hirose, Yuki, Nagahashi, Masayuki, Iso, Tetsuro, Fukutomi, Toshiaki, Ohishi, Maki, Endo, Keiko, Uemura, Takefumi, Nishito, Yasumasa, Okuda, Shujiro, Obata, Miki, Kouno, Tsuguka, Imamura, Riyo, Tada, Yukio, Obata, Rika, Yasuda, Daisuke, Takahashi, Kyoko, Fujimura, Tsutomu, Pi, Jingbo, Lee, Myung-Shik, Ueno, Takashi, Ohe, Tomoyuki, Mashino, Tadahiko, Wakai, Toshifumi, Kojima, Hirotatsu, Okabe, Takayoshi, Nagano, Tetsuo, Motohashi, Hozumi, Waguri, Satoshi, Soga, Tomoyoshi, Yamamoto, Masayuki, Tanaka, Keiji, Komatsu, Masaaki

“…p62/Sqstm1 is a multifunctional protein involved in cell survival, growth and death, that is degraded by autophagy. Amplification of the p62/Sqstm1 gene, and…”
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Acute exercise induces FGF21 expression in mice and in healthy humans by Kim, Kook Hwan, Kim, Seong Hun, Min, Young-Ki, Yang, Hun-Mo, Lee, Jeong-Beom, Lee, Myung-Shik

“…Fibroblast growth factor 21 (FGF21) plays an important role in the regulation of energy homeostasis during starvation and has an excellent therapeutic…”
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Ezetimibe ameliorates steatohepatitis via AMP activated protein kinase-TFEB-mediated activation of autophagy and NLRP3 inflammasome inhibition by Kim, Soo Hyun, Kim, Gyuri, Han, Dai Hoon, Lee, Milim, Kim, Irene, Kim, Bohkyung, Kim, Kook Hwan, Song, Young-Mi, Yoo, Jeong Eun, Wang, Hye Jin, Bae, Soo Han, Lee, Yong-Ho, Lee, Byung-Wan, Kang, Eun Seok, Cha, Bong-Soo, Lee, Myung-Shik

“…Impairment in macroautophagy/autophagy flux and inflammasome activation are common characteristics of nonalcoholic steatohepatitis (NASH). Considering the lack…”
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Autophagy deficiency leads to protection from obesity and insulin resistance by inducing Fgf21 as a mitokine by Kim, Kook Hwan, Jeong, Yeon Taek, Oh, Hyunhee, Kim, Seong Hun, Cho, Jae Min, Kim, Yo-Na, Kim, Su Sung, Kim, Do Hoon, Hur, Kyu Yeon, Kim, Hyoung Kyu, Ko, TaeHee, Han, Jin, Kim, Hong Lim, Kim, Jin, Back, Sung Hoon, Komatsu, Masaaki, Chen, Hsiuchen, Chan, David C, Konishi, Morichika, Itoh, Nobuyuki, Choi, Cheol Soo, Lee, Myung-Shik

“…Defects in mitochondrial function have been believed to contribute to insulin resistance. Myung-Shik Lee and colleagues now show that mitochondrial dysfunction…”
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