In vitro and in vivo antibacterial activity of tazobactam/piperacillin

We studied the β-lactamase inhibitory activity of tazobactam (TAZ) and the in vitro and in vivo antibacterial activity of tazobactam/piperacillin (TAZ/PIPC). The following results were obtained. 1) TAZ inhibited various β-lactamases more effectively than sulbactam. A progressiv inhibition of TAZ aga...

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Bibliographic Details
Published in:	CHEMOTHERAPY Vol. 42; no. Supplement2; pp. 164 - 177
Main Authors:	Minami, Shinzaburo, Araki, Harumi, Yamada, Hisashi, Fujimaki, Kazuo, Okamoto, Seiki, Kitayama, Rieko, Myohara, Yuki, Matsumura, Naoki, Ogake, Naoko, Horii, Taeko, Maehana, Junko, Yasuda, Takashi, Watanabe, Yasuo, Narita, Hirokazu
Format:	Journal Article
Language:	English Japanese
Published:	Japanese Society of Chemotherapy 1994
Subjects:	tazobactam tazobactam/piperacillin
Online Access:	Get full text
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Summary:	We studied the β-lactamase inhibitory activity of tazobactam (TAZ) and the in vitro and in vivo antibacterial activity of tazobactam/piperacillin (TAZ/PIPC). The following results were obtained. 1) TAZ inhibited various β-lactamases more effectively than sulbactam. A progressiv inhibition of TAZ against cephalosporinases was observed. 2) TAZ/PIPC exhibited a broad spectrum of antibacterial activity and potent activity against aerobic and anaerobic bacteria. 3) TAZ enhanced the activity of PIPC against PIPC-resistant bacteria such as Staphylococcus aureus (methicillin-susceptible), Staphylococcus epidermidis (methicillin-susceptible), Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Haemophilus influenzae, Moraxella catarrhalis and Bacteroides fragilis, and TAZ/PIPC was equally or more active than sulbactam/cefoperazone (SBT/CPZ), cefotiam and ceftazidime (CAZ) against P. aeruginosa, H. influenzae, M catarrhalis and B. fragilis resistant to PIPC. 4) The inducer activity of TAZ/PIPC for β-lactamase production was as low as that of PIPC. 5) TAZ/PIPC was more active than PIPC against rat pouch mixed infection caused by E. coli and penicillinase-producing S. epidermidis, rat intrauterine infection and mouse urinary tract infection caused by PIPC-resistant E. coli. TAZ/PIPC was more active than SBT/CPZ against rat pouch infection caused by P. aeruginosa highly resistant to CAZ.
ISSN:	0009-3165 1884-5894
DOI:	10.11250/chemotherapy1953.42.Supplement2_164