Search Results - "Mynatt, Randall L."

The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance by Dixit, Vishwa Deep, Vandanmagsar, Bolormaa, Youm, Yun-Hee, Ravussin, Anthony, Galgani, Jose E, Stadler, Krisztian, Mynatt, Randall L, Ravussin, Eric, Stephens, Jacqueline M

“…Obesity is generally considered an inflammatory state. Vishwa Dixit and his colleagues have now shown that excess dietary lipids leads to the activation of the…”
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Muscle-Specific Deletion of Carnitine Acetyltransferase Compromises Glucose Tolerance and Metabolic Flexibility by Muoio, Deborah M., Noland, Robert C., Kovalik, Jean-Paul, Seiler, Sarah E., Davies, Michael N., DeBalsi, Karen L., Ilkayeva, Olga R., Stevens, Robert D., Kheterpal, Indu, Zhang, Jingying, Covington, Jeffrey D., Bajpeyi, Sudip, Ravussin, Eric, Kraus, William, Koves, Timothy R., Mynatt, Randall L.

“…The concept of “metabolic inflexibility” was first introduced to describe the failure of insulin-resistant human subjects to appropriately adjust mitochondrial…”
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PHDs/CPT1B/VDAC1 axis regulates long-chain fatty acid oxidation in cardiomyocytes by Angelini, Aude, Saha, Pradip K., Jain, Antrix, Jung, Sung Yun, Mynatt, Randall L., Pi, Xinchun, Xie, Liang

“…Cardiac metabolism is a high-oxygen-consuming process, showing a preference for long-chain fatty acid (LCFA) as the fuel source under physiological conditions…”
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Impaired mitochondrial fat oxidation induces adaptive remodeling of muscle metabolism by Wicks, Shawna E, Bolormaa Vandanmagsar, Kimberly R. Haynie, Scott E. Fuller, Jaycob D. Warfel, Jacqueline M. Stephens, Miao Wang, Xianlin Han, Jingying Zhang, Robert C. Noland, Randall L. Mynatt

“…The correlations between intramyocellular lipid (IMCL), decreased fatty acid oxidation (FAO), and insulin resistance have led to the hypothesis that impaired…”
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Impaired Mitochondrial Fat Oxidation Induces FGF21 in Muscle by Vandanmagsar, Bolormaa, Warfel, Jaycob D., Wicks, Shawna E., Ghosh, Sujoy, Salbaum, J. Michael, Burk, David, Dubuisson, Olga S., Mendoza, Tamra M., Zhang, Jingying, Noland, Robert C., Mynatt, Randall L.

“…Fatty acids are the primary fuel source for skeletal muscle during most of our daily activities, and impaired fatty acid oxidation (FAO) is associated with…”
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Examination of carnitine palmitoyltransferase 1 abundance in white adipose tissue: implications in obesity research by Warfel, Jaycob D, Vandanmagsar, Bolormaa, Dubuisson, Olga S, Hodgeson, Sydney M, Elks, Carrie M, Ravussin, Eric, Mynatt, Randall L

“…Carnitine palmitoyltransferase 1 (CPT1) is essential for the transport of long-chain fatty acids into the mitochondria for oxidation. Recently, it was reported…”
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NT-PGC-1α deficiency decreases mitochondrial FA oxidation in brown adipose tissue and alters substrate utilization in vivo by Kim, Jihyun, Park, Min Sung, Ha, Kyoungsoo, Park, Chulhong, Lee, Jisu, Mynatt, Randall L., Chang, Ji Suk

“…Transcriptional coactivator PPAR γ coactivator (PGC)-1α and its splice variant N-terminal (NT)-PGC-1α mediate transcriptional regulation of brown adipose…”
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The RNA binding protein HuR influences skeletal muscle metabolic flexibility in rodents and humans by Mynatt, Randall L., Noland, Robert C., Elks, Carrie M., Vandanmagsar, Bolormaa, Bayless, David S., Stone, Allison C., Ghosh, Sujoy, Ravussin, Eric, Warfel, Jaycob D.

“…Metabolic flexibility can be assessed by changes in respiratory exchange ratio (RER) following feeding. Though metabolic flexibility (difference in RER between…”
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Loss of Oncostatin M Signaling in Adipocytes Induces Insulin Resistance and Adipose Tissue Inflammation in Vivo by Elks, Carrie M., Zhao, Peng, Grant, Ryan W., Hang, Hardy, Bailey, Jennifer L., Burk, David H., McNulty, Margaret A., Mynatt, Randall L., Stephens, Jacqueline M.

“…Oncostatin M (OSM) is a multifunctional gp130 cytokine. Although OSM is produced in adipose tissue, it is not produced by adipocytes. OSM expression is…”
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Myeloid-specific deletion of NOX2 prevents the metabolic and neurologic consequences of high fat diet by Pepping, Jennifer K, Vandanmagsar, Bolormaa, Fernandez-Kim, Sun-Ok, Zhang, Jingying, Mynatt, Randall L, Bruce-Keller, Annadora J

“…High fat diet-induced obesity is associated with inflammatory and oxidative signaling in macrophages that likely participates in metabolic and physiologic…”
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Characterization of Peripheral Circadian Clocks in Adipose Tissues by ZVONIC, Sanjin, PTITSYN, Andrey A, CONRAD, Steven A, SCOTT, L. Keith, FLOYD, Z. Elizabeth, KILROY, Gail, XIYING WU, GOH, Brian C, MYNATT, Randall L, GIMBLE, Jeffrey M

“…Characterization of Peripheral Circadian Clocks in Adipose Tissues Sanjin Zvonic 1 , Andrey A. Ptitsyn 2 , Steven A. Conrad 3 , L. Keith Scott 3 , Z. Elizabeth…”
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Muscle-Specific Deletion of Toll-like Receptor 4 Impairs Metabolic Adaptation to Wheel Running in Mice by ALI, MOSTAFA M., MCMILLAN, RYAN P., FAUSNACHT, DANE W., KAVANAUGH, JOHN W., HARVEY, MORDECAI M., STEVENS, JOSEPH R., WU, YARU, MYNATT, RANDALL L., HULVER, MATTHEW W.

“…PURPOSEToll-like receptor 4 (TLR4) is an inflammatory receptor expressed ubiquitously in immune cells as well as skeletal muscle and other metabolic tissues…”
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Diet-induced adipose tissue expansion is mitigated in mice with a targeted inactivation of mesoderm specific transcript (Mest) by Anunciado-Koza, Rea P, Manuel, Justin, Mynatt, Randall L, Zhang, Jingying, Kozak, Leslie P, Koza, Robert A

“…Interindividual variation of white adipose tissue (WAT) expression of mesoderm specific transcript (Mest), a paternally-expressed imprinted gene belonging to…”
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A low fat diet ameliorates pathology but retains beneficial effects associated with CPT1b knockout in skeletal muscle by Warfel, Jaycob D, Vandanmagsar, Bolormaa, Wicks, Shawna E, Zhang, Jingying, Noland, Robert C, Mynatt, Randall L

“…Inhibiting fatty acid oxidation is one approach to lowering glucose levels in diabetes. Skeletal muscle specific Carnitine Palmitoyltransferase 1b knockout…”
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Inactivation of the Mitochondrial Carrier SLC25A25 (ATP-Mg2+/Pi Transporter) Reduces Physical Endurance and Metabolic Efficiency in Mice by Anunciado-Koza, Rea P., Zhang, Jingying, Ukropec, Jozef, Bajpeyi, Sudip, Koza, Robert A., Rogers, Richard C., Cefalu, William T., Mynatt, Randall L., Kozak, Leslie P.

“…An ATP-Mg2+/Pi inner mitochondrial membrane solute transporter (SLC25A25), which is induced during adaptation to cold stress in the skeletal muscle of mice…”
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Pancreatic deletion of the interleukin-1 receptor disrupts whole body glucose homeostasis and promotes islet β-cell de-differentiation by Burke, Susan J., Batdorf, Heidi M., Burk, David H., Martin, Thomas M., Mendoza, Tamra, Stadler, Krisztian, Alami, Wateen, Karlstad, Michael D., Robson, Matthew J., Blakely, Randy D., Mynatt, Randall L., Collier, J. Jason

“…Pancreatic tissue, and islets in particular, are enriched in expression of the interleukin-1 receptor type I (IL-1R). Because of this enrichment, islet β-cells…”
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AgRP Neurons Require Carnitine Acetyltransferase to Regulate Metabolic Flexibility and Peripheral Nutrient Partitioning by Reichenbach, Alex, Stark, Romana, Mequinion, Mathieu, Denis, Raphael R.G., Goularte, Jeferson F., Clarke, Rachel E., Lockie, Sarah H., Lemus, Moyra B., Kowalski, Greg M., Bruce, Clinton R., Huang, Cheng, Schittenhelm, Ralf B., Mynatt, Randall L., Oldfield, Brian J., Watt, Matthew J., Luquet, Serge, Andrews, Zane B.

“…AgRP neurons control peripheral substrate utilization and nutrient partitioning during conditions of energy deficit and nutrient replenishment, although the…”
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Skeletal muscle overexpression of nicotinamide phosphoribosyl transferase in mice coupled with voluntary exercise augments exercise endurance by Costford, Sheila R, Brouwers, Bram, Hopf, Meghan E, Sparks, Lauren M, Dispagna, Mauro, Gomes, Ana P, Cornnell, Heather H, Petucci, Chris, Phelan, Peter, Xie, Hui, Yi, Fanchao, Walter, Glenn A, Osborne, Timothy F, Sinclair, David A, Mynatt, Randall L, Ayala, Julio E, Gardell, Stephen J, Smith, Steven R

“…Nicotinamide phosphoribosyl transferase (NAMPT) is the rate-limiting enzyme in the salvage pathway that produces nicotinamide adenine dinucleotide (NAD ), an…”
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Genetic Dissection of the Functions of the Melanocortin-3 Receptor, a Seven-transmembrane G-protein-coupled Receptor, Suggests Roles for Central and Peripheral Receptors in Energy Homeostasis by Begriche, Karima, Levasseur, Peter R., Zhang, Jingying, Rossi, Jari, Skorupa, Danielle, Solt, Laura A., Young, Brandon, Burris, Thomas P., Marks, Daniel L., Mynatt, Randall L., Butler, Andrew A.

“…The melanocortin-3 receptor (MC3R) gene is pleiotropic, influencing body composition, natriuresis, immune function, and entrainment of circadian rhythms to…”
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Human mesenchymal stem cells as an in vitro model for human adipogenesis by Janderova, L, McNeil, M, Murrell, A.N, Mynatt, R.L, Smith, S.R

“…Objective: To validate the human mesenchymal stem cells (hMSCs) as a new in vitro model for the study of human adipogenesis, to develop the optimal protocol…”
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