Search Results - "Myles, Diana G"

A Role for Sperm Surface Protein Disulfide Isomerase Activity in Gamete Fusion: Evidence for the Participation of ERp57 by Ellerman, Diego A., Myles, Diana G., Primakoff, Paul

“…In mammals, sperm-egg interaction is based on molecular events either unique to gametes or also present in somatic cells. In gamete fusion, it is unknown which…”
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Cell–cell membrane fusion during mammalian fertilization by Primakoff, Paul, Myles, Diana G.

“…The mechanism of sperm–egg fusion in mammals is a research area that has greatly benefited from the use of gene deletion technology. Because fertilization is…”
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Penetration, Adhesion, and Fusion in Mammalian Sperm-Egg Interaction by Primakoff, Paul, Myles, Diana G.

“…Fertilization is the sum of the cellular mechanisms that pass the genome from one generation to the next and initiate development of a new organism. A typical,…”
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Oocyte CD9 is enriched on the microvillar membrane and required for normal microvillar shape and distribution by Runge, Kathryn E., Evans, James E., He, Zhi-Yong, Gupta, Surabhi, McDonald, Kent L., Stahlberg, Henning, Primakoff, Paul, Myles, Diana G.

“…Microvilli are found on the surface of many cell types, including the mammalian oocyte, where they are thought to act in initial contact of sperm and oocyte…”
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Identification of an ADAM2-ADAM3 Complex on the Surface of Mouse Testicular Germ Cells and Cauda Epididymal Sperm by Nishimura, Hitoshi, Myles, Diana G., Primakoff, Paul

“…Male mice lacking ADAM2 (fertilin β) or ADAM3 (cyritestin) are infertile; cauda epididymal sperm (mature sperm) from these mutant mice cannot bind to the egg…”
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Can the presence of wild-type oocytes during insemination rescue the fusion defect of CD9 null oocytes? by Gupta, Surabhi, Primakoff, Paul, Myles, Diana G.

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Characterization of mouse sperm TMEM190, a small transmembrane protein with the trefoil domain: evidence for co-localization with IZUMO1 and complex formation with other sperm proteins by Nishimura, Hitoshi, Gupta, Surabhi, Myles, Diana G, Primakoff, Paul

“…TMEM190, a small transmembrane protein containing the trefoil domain, was previously identified by our proteomic analysis of mouse sperm. Two structural…”
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A Role for the Disintegrin Domain of Cyritestin, a Sperm Surface Protein Belonging to the ADAM Family, in Mouse Sperm-Egg Plasma Membrane Adhesion and Fusion by Yuan, Ruiyong, Primakoff, Paul, Myles, Diana G.

“…Sperm-egg plasma membrane fusion is preceded by sperm adhesion to the egg plasma membrane. Cell-cell adhesion frequently involves multiple adhesion molecules…”
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Residues SFQ (173-175) in the large extracellular loop of CD9 are required for gamete fusion by Zhu, Guo-Zhang, Miller, Brent J, Boucheix, Claude, Rubinstein, Eric, Liu, Christopher C, Hynes, Richard O, Myles, Diana G, Primakoff, Paul

“…Gamete fusion is the fundamental first step initiating development of a new organism. Female mice with a gene knockout for the tetraspanin CD9 (CD9 KO mice)…”
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Direct binding of the ligand PSG17 to CD9 requires a CD9 site essential for sperm-egg fusion by Ellerman, Diego A, Ha, Cam, Primakoff, Paul, Myles, Diana G, Dveksler, Gabriela S

“…The function currently attributed to tetraspanins is to organize molecular complexes in the plasma membrane by using multiple cis-interactions. Additionally,…”
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Defects in Secretory Pathway Trafficking During Sperm Development in Adam2 Knockout Mice by STEIN, Kathryn K, GO, Jowell C, PRIMAKOFF, Paul, MYLES, Diana G

“…Adam2 -null and Adam3 -null male mice exhibit reduced levels of one or more ADAM proteins on mature sperm, in addition to the loss of the genetically targeted…”
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A potential fusion peptide and an integrin ligand domain in a protein active in sperm-egg fusion by Blobel, Carl P, Wolfsberg, Tyra G, Turck, Christoph W, Myles, Diana G, Primakoff, Paul, White, Judith M

“…The union of sperm and egg is a special membrane fusion event that gives a signal to begin development. We have hypothesized that proteins mediating cell-cell…”
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The ADAM gene family: surface proteins with adhesion and protease activity by Primakoff, Paul, Myles, Diana G

“…An ADAM is a transmembrane protein that contains a disintegrin and metalloprotease domain and, therefore, it potentially has both cell adhesion and protease…”
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Proteomic analysis of sperm regions that mediate sperm-egg interactions by Stein, Kathryn K., Go, Jowell C., Lane, William S., Primakoff, Paul, Myles, Diana G.

“…The sperm interacts with three oocyte‐associated structures during fertilization: the cumulus cell layer surrounding the oocyte, the egg extracellular matrix…”
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Cell adhesion and fertilization: Steps in oocyte transport, sperm-zona pellucida interactions, and sperm-egg fusion by TALBOT, Prudence, SHUR, Barry D, MYLES, Diana G

“…Fertilization in mammals requires the successful completion of many steps, starting with the transport of gametes in the reproductive tract and ending with…”
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Defects in Secretory Pathway Trafficking During Sperm Development in Adam2 Knockout Mice1 by Stein, Kathryn K, Go, Jowell C, Primakoff, Paul, Myles, Diana G

“…Adam2-null and Adam3-null male mice exhibit reduced levels of one or more ADAM proteins on mature sperm, in addition to the loss of the genetically targeted…”
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Cell Adhesion and Fertilization: Steps in Oocyte Transport, Sperm-Zona Pellucida Interactions, and Sperm-Egg Fusion1 by Talbot, Prudence, Shur, Barry D, Myles, Diana G

“…Fertilization in mammals requires the successful completion of many steps, starting with the transport of gametes in the reproductive tract and ending with…”
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Fertilization Defects in Sperm from Mice Lacking Fertilin β by Cho, Chunghee, Donna O'Dell Bunch, Faure, Jean-Emmanuel, Goulding, Eugenia H., Eddy, Edward M., Primakoff, Paul, Myles, Diana G.

“…Fertilin, a member of the ADAM family, is found on the plasma membrane of mammalian sperm. Sperm from mice lacking fertilin β were shown to be deficient in…”
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None of the integrins known to be present on the mouse egg or to be ADAM receptors are essential for sperm–egg binding and fusion by He, Zhi-Yong, Brakebusch, Cord, Fässler, Reinhard, Kreidberg, Jordan A, Primakoff, Paul, Myles, Diana G

“…Antibody inhibition and α6β1 ligand binding experiments indicate that the egg integrin α6β1 functions as a receptor for sperm during gamete fusion; yet, eggs…”
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ADAM, a novel family of membrane proteins containing A Disintegrin And Metalloprotease domain: multipotential functions in cell-cell and cell-matrix interactions by Wolfsberg, T G, Primakoff, P, Myles, D G, White, J M

“…The ADAMs, a newly discovered gene family encoding membrane proteins with a disintegrin and metalloprotease domain, are described. ADAMs are unique in that…”
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