Search Results - "Mykhailiuk, Pavel K."

Fluorinated Pyrazoles: From Synthesis to Applications by Mykhailiuk, Pavel K

“…Fluorinated pyrazoles play an important role in medicinal chemistry, drug discovery, agrochemistry, coordination chemistry, and organometallic chemistry. Since…”
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A Practical and Scalable Approach to Fluoro‐Substituted Bicyclo[1.1.1]pentanes by Bychek, Roman, Mykhailiuk, Pavel K.

“…After more than 20 years of trials, a practical scalable approach to fluoro‐substituted bicyclo[1.1.1]pentanes (F‐BCPs) has been developed. The physicochemical…”
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Fluorine-Containing Prolines: Synthetic Strategies, Applications, and Opportunities by Mykhailiuk, Pavel K.

“…Fluorinated prolines play an important role in peptide studies, protein engineering, medicinal chemistry, drug discovery, and agrochemistry. Since the first…”
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Generation of C2F5CHN2 In Situ and Its First Reaction: [3+2] Cycloaddition with Alkenes by Mykhailiuk, Pavel K

“…The novel chemical reagent, C2F5CHN2, is generated in situ from C2F5CH2NH2⋅HCl and sodium nitrite. It reacts with mono‐ and disubstituted electron‐deficient…”
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2-Oxabicyclo[2.1.1]hexanes as saturated bioisosteres of the ortho-substituted phenyl ring by Denisenko, Aleksandr, Garbuz, Pavel, Voloshchuk, Nataliya M., Holota, Yuliia, Al-Maali, Galeb, Borysko, Petro, Mykhailiuk, Pavel K.

“…The ortho -substituted phenyl ring is a basic structural element in chemistry. It is found in more than three hundred drugs and agrochemicals. During the past…”
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Water‐Soluble Non‐Classical Benzene Mimetics by Levterov, Vadym V., Panasyuk, Yaroslav, Pivnytska, Valentyna O., Mykhailiuk, Pavel K.

“…A new generation of saturated benzene mimetics, 2‐oxabicyclo[2.1.1]hexanes, was developed. These compounds were designed as analogues of bicyclo[1.1.1]pentane…”
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Saturated Bioisosteres of ortho‐Substituted Benzenes by Denisenko, Aleksandr, Garbuz, Pavel, Shishkina, Svetlana V., Voloshchuk, Nataliya M., Mykhailiuk, Pavel K.

“…Saturated bioisosteres of ortho‐disubstituted benzenes (bicyclo[2.1.1]hexanes) were synthesized, characterized and validated. These cores were incorporated…”
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Rapid and Scalable Halosulfonylation of Strain‐Release Reagents by Pickford, Helena D., Ripenko, Vasyl, McNamee, Ryan E., Holovchuk, Serhii, Thompson, Amber L., Smith, Russell C., Mykhailiuk, Pavel K., Anderson, Edward A.

“…Sulfonylated aromatics are commonplace motifs in drugs and agrochemicals. However, methods for the direct synthesis of sulfonylated non‐classical arene…”
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Large-Scale Synthesis and Modifications of Bicyclo[1.1.1]pentane-1,3-dicarboxylic Acid (BCP) by Ripenko, Vasyl, Vysochyn, Daniil, Klymov, Ivan, Zhersh, Serhii, Mykhailiuk, Pavel K

“…In flow photochemical addition of propellane to diacetyl allowed construction of the bicyclo[1.1.1]­pentane (BCP) core in a 1 kg scale within 1 day. Haloform…”
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General Synthesis of 3‐Azabicyclo[3.1.1]heptanes and Evaluation of Their Properties as Saturated Isosteres by Dibchak, Dmitry, Snisarenko, Mariya, Mishuk, Artem, Shablykin, Oleh, Bortnichuk, Lina, Klymenko‐Ulianov, Oleksii, Kheylik, Yurii, Sadkova, Iryna V., Rzepa, Henry S., Mykhailiuk, Pavel K.

“…A general approach to 3‐azabicyclo[3.1.1]heptanes by reduction of spirocyclic oxetanyl nitriles was developed. The mechanism, scope, and scalability of this…”
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A Radical Approach to Anionic Chemistry: Synthesis of Ketones, Alcohols, and Amines by Ni, Shengyang, Padial, Natalia M, Kingston, Cian, Vantourout, Julien C, Schmitt, Daniel C, Edwards, Jacob T, Kruszyk, Monika M, Merchant, Rohan R, Mykhailiuk, Pavel K, Sanchez, Brittany B, Yang, Shouliang, Perry, Matthew A, Gallego, Gary M, Mousseau, James J, Collins, Michael R, Cherney, Robert J, Lebed, Pavlo S, Chen, Jason S, Qin, Tian, Baran, Phil S

“…Historically accessed through two-electron, anionic chemistry, ketones, alcohols, and amines are of foundational importance to the practice of organic…”
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1‐Substituted 2‐Azaspiro[3.3]heptanes: Overlooked Motifs for Drug Discovery by Kirichok, Alexander A., Shton, Iryna, Kliachyna, Maria, Pishel, Iryna, Mykhailiuk, Pavel K.

“…The 2‐substituted piperidine core is found in drugs (18 FDA‐approved drugs), however, their spirocyclic analogues remain unknown. Described here is the…”
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2,2,2-Trifluorodiazoethane (CF3CHN2): A Long Journey since 1943 by Mykhailiuk, Pavel K

“…2,2,2-Trifluorodiazoethane (CF3CHN2) has been proven to be a valuable reagent for the rapid synthesis of various classes of trifluoromethyl-substituted organic…”
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2-Oxabicyclo[2.2.2]octane as a new bioisostere of the phenyl ring by Levterov, Vadym V., Panasiuk, Yaroslav, Sahun, Kateryna, Stashkevych, Oleksandr, Badlo, Valentyn, Shablykin, Oleh, Sadkova, Iryna, Bortnichuk, Lina, Klymenko-Ulianov, Oleksii, Holota, Yuliia, Lachmann, Leonid, Borysko, Petro, Horbatok, Kateryna, Bodenchuk, Iryna, Bas, Yuliia, Dudenko, Dmytro, Mykhailiuk, Pavel K.

“…The phenyl ring is a basic structural element in chemistry. Here, we show the design, synthesis, and validation of its new saturated bioisostere with improved…”
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Synthesis of Spirocyclic Pyrrolidines: Advanced Building Blocks for Drug Discovery by Chalyk, Bohdan A., Butko, Maryna V., Yanshyna, Oksana O., Gavrilenko, Konstantin S., Druzhenko, Tetiana V., Mykhailiuk, Pavel K.

“…In the context of drug discovery, novel spirocyclic pyrrolidines have been synthesized in two steps from common three‐ to seven‐membered‐ring (hetero)alicyclic…”
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Synthesis of Functionalized Difluorocyclopropanes: Unique Building Blocks for Drug Discovery by Bychek, Roman M., Levterov, Vadym V., Sadkova, Iryna V., Tolmachev, Andrey A., Mykhailiuk, Pavel K.

“…Difluorocyclopropane‐containing building blocks for drug discovery were synthesized from the functionalized alkenes and TMSCF3/NaI. Novel fluorinated acids,…”
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Deoxofluorination of Aliphatic Carboxylic Acids: A Route to Trifluoromethyl-Substituted Derivatives by Bugera, Maksym, Trofymchuk, Serhii, Tarasenko, Karen, Zaporozhets, Olga, Pustovit, Yurii, Mykhailiuk, Pavel K

“…A practical method for the synthesis of functionalized aliphatic trifluoromethyl-substituted derivatives from aliphatic acids is developed. The transformation…”
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Synthesis of 2,2‐Disubstituted Spirocyclic Pyrrolidines by Intramolecular Dieckmann Condensation by Fominova, Kateryna, Diachuk, Taras, Sadkova, Iryna V., Mykhailiuk, Pavel K.

“…Novel spirocyclic pyrrolidines were synthesized in three steps from cyclic α‐amino acids with a 3‐ to 7‐membered cycle. The key transformation was the…”
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Difluoromethyl Nitrile Oxide (CF2HCNO): A Neglected Chemical Reagent by Khutorianskyi, Andrii, Chalyk, Bohdan, Borysko, Petro, Kondratiuk, Anna, Mykhailiuk, Pavel K.

“…A novel chemical reagent – difluoromethyl nitrile oxide, CF2HCNO – was generated in situ for the first time. The synthesis commenced with ethyl difluoroacetate…”
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[2+2]-Photocycloaddition of N‑Benzylmaleimide to Alkenes As an Approach to Functional 3‑Azabicyclo[3.2.0]heptanes by Skalenko, Yevhen A, Druzhenko, Tetiana V, Denisenko, Aleksandr V, Samoilenko, Maryna V, Dacenko, Oleksandr P, Trofymchuk, Serhii A, Grygorenko, Oleksandr O, Tolmachev, Andrey A, Mykhailiuk, Pavel K

“…A one-step synthesis of functionalized 3-azabicyclo[3.2.0]­heptanes by [2+2]-photochemical intermolecular cycloaddition of N-benzylmaleimide to alkenes was…”
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