Search Results - "Myers, Regina M."

Single-cell multiomics dissection of basal and antigen-specific activation states of CD19-targeted CAR T cells by Bai, Zhiliang, Lundh, Stefan, Kim, Dongjoo, Woodhouse, Steven, Barrett, David M, Myers, Regina M, Grupp, Stephan A, Maus, Marcela V, June, Carl H, Camara, Pablo G, Melenhorst, J Joseph, Fan, Rong

“…BackgroundAutologous T cells engineered to express a chimeric antigen receptor (CAR) specific for CD19 molecule have transformed the therapeutic landscape in…”
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Household income and health‐related quality of life in children receiving treatment for acute myeloid leukemia: Potential impact of selection bias in health equity research by Newman, Haley, Li, Yimei, Huang, Yuan‐Shung V., Elgarten, Caitlin W., Myers, Regina M., Ruiz, Jenny, Zheng, Daniel J., Leahy, Alison Barz, Aftandilian, Catherine, Arnold, Staci D., Bona, Kira, Gramatges, M. Monica, Heneghan, Mallorie B., Maloney, Kelly W., Modi, Arunkumar J., Mody, Rajen J., Morgan, Elaine, Rubnitz, Jeffrey, Winick, Naomi, Wilkes, Jennifer J., Seif, Alix E., Fisher, Brian T., Aplenc, Richard, Getz, Kelly D.

“…Objective Examine the influence of household income on health‐related quality of life (HRQOL) among children with newly diagnosed acute myeloid leukemia (AML)…”
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How I use risk factors for success or failure of CD19 CAR T cells to guide management of children and AYA with B-cell ALL by Myers, Regina M., Shah, Nirali N., Pulsipher, Michael A.

“…[Display omitted] By overcoming chemotherapeutic resistance, chimeric antigen receptor (CAR) T cells facilitate deep, complete remissions and offer the…”
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Driving two chimeric antigen receptors (CARs) in a row to reduce antigen escape in B-cell acute lymphocytic leukaemia by Myers, Regina M, Grupp, Stephan A

“…Notably, a recent study of simultaneous co-infusion of CD19 and CD22 CAR T cells also demonstrated promising results with high event-free survival rates.4 The…”
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Blinatumomab Nonresponse and High-Disease Burden Are Associated With Inferior Outcomes After CD19-CAR for B-ALL by Myers, Regina M, Taraseviciute, Agne, Steinberg, Seth M, Lamble, Adam J, Sheppard, Jennifer, Yates, Bonnie, Kovach, Alexandra E, Wood, Brent, Borowitz, Michael J, Stetler-Stevenson, Maryalice, Yuan, Constance M, Pillai, Vinodh, Foley, Toni, Chung, Perry, Chen, Lee, Lee, Daniel W, Annesley, Colleen, DiNofia, Amanda, Grupp, Stephan A, John, Samuel, Bhojwani, Deepa, Brown, Patrick A, Laetsch, Theodore W, Gore, Lia, Gardner, Rebecca A, Rheingold, Susan R, Pulsipher, Michael A, Shah, Nirali N

“…CD19-targeted chimeric antigen receptor T cells (CD19-CAR) and blinatumomab effectively induce remission in relapsed or refractory B-cell acute lymphoblastic…”
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Integrative Bulk and Single-Cell Profiling of Premanufacture T-cell Populations Reveals Factors Mediating Long-Term Persistence of CAR T-cell Therapy by Chen, Gregory M, Chen, Changya, Das, Rajat K, Gao, Peng, Chen, Chia-Hui, Bandyopadhyay, Shovik, Ding, Yang-Yang, Uzun, Yasin, Yu, Wenbao, Zhu, Qin, Myers, Regina M, Grupp, Stephan A, Barrett, David M, Tan, Kai

“…The adoptive transfer of chimeric antigen receptor (CAR) T cells represents a breakthrough in clinical oncology, yet both between- and within-patient…”
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Risk-Adapted Preemptive Tocilizumab to Prevent Severe Cytokine Release Syndrome After CTL019 for Pediatric B-Cell Acute Lymphoblastic Leukemia: A Prospective Clinical Trial by Kadauke, Stephan, Myers, Regina M, Li, Yimei, Aplenc, Richard, Baniewicz, Diane, Barrett, David M, Barz Leahy, Allison, Callahan, Colleen, Dolan, Joseph G, Fitzgerald, Julie C, Gladney, Whitney, Lacey, Simon F, Liu, Hongyan, Maude, Shannon L, McGuire, Regina, Motley, Laura S, Teachey, David T, Wertheim, Gerald B, Wray, Lisa, DiNofia, Amanda M, Grupp, Stephan A

“…To prospectively evaluate the effectiveness of risk-adapted preemptive tocilizumab (PT) administration in preventing severe cytokine release syndrome (CRS)…”
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Humanized CD19-Targeted Chimeric Antigen Receptor (CAR) T Cells in CAR-Naive and CAR-Exposed Children and Young Adults With Relapsed or Refractory Acute Lymphoblastic Leukemia by Myers, Regina M, Li, Yimei, Barz Leahy, Allison, Barrett, David M, Teachey, David T, Callahan, Colleen, Fasano, Christina C, Rheingold, Susan R, DiNofia, Amanda, Wray, Lisa, Aplenc, Richard, Baniewicz, Diane, Liu, Hongyan, Shaw, Pamela A, Pequignot, Edward, Getz, Kelly D, Brogdon, Jennifer L, Fesnak, Andrew D, Siegel, Donald L, Davis, Megan M, Bartoszek, Chelsie, Lacey, Simon F, Hexner, Elizabeth O, Chew, Anne, Wertheim, Gerald B, Levine, Bruce L, June, Carl H, Grupp, Stephan A, Maude, Shannon L

“…CD19-targeted chimeric antigen receptor (CAR)-modified T cells demonstrate unprecedented responses in B-cell acute lymphoblastic leukemia (B-ALL); however,…”
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Neurobiological and Memory Models of Risky Decision Making in Adolescents Versus Young Adults by Reyna, Valerie F., Estrada, Steven M., DeMarinis, Jessica A., Myers, Regina M., Stanisz, Janine M., Mills, Britain A.

“…Predictions of fuzzy-trace theory and neurobiological approaches are examined regarding risk taking in a classic decision-making task-the framing task-as well…”
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A Prospective Study of Anxiety, Depression, and Behavioral Changes in the First Year After a Diagnosis of Childhood Acute Lymphoblastic Leukemia: Report From the Children's Oncology Group by MYERS, Regina M, BALSAMO, Lyn, XIAOMIN LU, DEVIDAS, Meenakshi, HUNGER, Stephen P, CARROLL, William L, WINICK, Naomi J, MALONEY, Kelly W, KADAN-LOTTICK, Nina S

“…The authors prospectively assessed anxiety, depression, and behavior in children with standard-risk acute lymphoblastic leukemia (SR-ALL) during the first year…”
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Impact of poverty and neighborhood opportunity on outcomes for children treated with CD19-directed CAR T-cell therapy by Newman, Haley, Li, Yimei, Liu, Hongyan, Myers, Regina M., Tam, Vicky, DiNofia, Amanda, Wray, Lisa, Rheingold, Susan R., Callahan, Colleen, White, Claire, Baniewicz, Diane, Winestone, Lena E., Kadauke, Stephan, Diorio, Caroline, June, Carl H., Getz, Kelly D., Aplenc, Richard, Teachey, David T., Maude, Shannon L., Grupp, Stephan A., Bona, Kira, Leahy, Allison Barz

“…•CAR T-cell therapy produces equivalent survival for children with r/r ALL, regardless of household poverty or neighborhood opportunity.•CAR T-cell therapy may…”
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Statistical Considerations for Analyses of Time-To-Event Endpoints in Oncology Clinical Trials: Illustrations with CAR-T Immunotherapy Studies by Li, Yimei, Hwang, Wei-Ting, Maude, Shannon L., Teachey, David T., Frey, Noelle V., Myers, Regina M., Barz Leahy, Allison, Liu, Hongyan, Porter, David L., Grupp, Stephan A., Shaw, Pamela A.

“…Abstract Chimeric antigen receptor T-cell (CAR-T) therapy is an exciting development in the field of cancer immunology and has received a lot of interest in…”
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Quadriparesis and paraparesis following chimeric antigen receptor T-cell therapy in children and adolescents by Diorio, Caroline, Hernandez-Miyares, Laura, Espinoza, Diego A., Banwell, Brenda L., Bar-Or, Amit, DiNofia, Amanda M., Barz Leahy, Allison, Martinez, Zachary, Myers, Regina M., Hopkins, Sarah E., Rheingold, Susan R., Teachey, David T., Viaene, Angela N., Wray, Lisa M., Maude, Shannon L., Grupp, Stephan A., McGuire, Jennifer L.

“…•Quadriparesis and paraparesis are rare toxicities seen after CART therapy in children.•The mechanism of post-CART paresis is likely complex but not clearly…”
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Prospective, longitudinal assessment of quality of life in children from diagnosis to 3 months off treatment for standard risk acute lymphoblastic leukemia: Results of Children's Oncology Group study AALL0331 by Mitchell, Hannah‐Rose, Lu, Xiaomin, Myers, Regina M., Sung, Lillian, Balsamo, Lyn M., Carroll, William L., Raetz, Elizabeth, Loh, Mignon L., Mattano, Leonard A., Winick, Naomi J., Devidas, Meenakshi, Hunger, Stephen P., Maloney, Kelly, Kadan‐Lottick, Nina S.

“…Standard risk acute lymphoblastic leukemia (SR‐ALL) has high cure rates, but requires 2–3 years of therapy. We aimed to (i) prospectively evaluate…”
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Single-cell antigen-specific landscape of CAR T infusion product identifies determinants of CD19-positive relapse in patients with ALL by Bai, Zhiliang, Woodhouse, Steven, Zhao, Ziran, Arya, Rahul, Govek, Kiya, Kim, Dongjoo, Lundh, Stefan, Baysoy, Alev, Sun, Hongxing, Deng, Yanxiang, Xiao, Yang, Barrett, David M, Myers, Regina M, Grupp, Stephan A, June, Carl H, Fan, Rong, Camara, Pablo G, Melenhorst, J Joseph

“…A notable number of acute lymphoblastic leukemia (ALL) patients develop CD19-positive relapse within 1 year after receiving chimeric antigen receptor (CAR) T…”
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Chimeric antigen receptor T cell therapy for pediatric and young adult B cell acute lymphoblastic leukemia by Myers, Regina M, Dolan, Joseph, Teachey, David T

“…Though 85% of children and young adults with acute lymphoblastic leukemia (ALL) are cured, until recently, the prognosis of relapsed or refractory disease has…”
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Preinfusion factors impacting relapse immunophenotype following CD19 CAR T cells by Lamble, Adam J., Myers, Regina M., Taraseviciute, Agne, John, Samuel, Yates, Bonnie, Steinberg, Seth M., Sheppard, Jennifer, Kovach, Alexandra E., Wood, Brent, Borowitz, Michael J., Stetler-Stevenson, Maryalice, Yuan, Constance M., Pillai, Vinodh, Foley, Toni, Chung, Perry, Chen, Lee, Lee, Daniel W., Annesley, Colleen, DiNofia, Amanda, Grupp, Stephan A., Verneris, Michael R., Gore, Lia, Laetsch, Theodore W., Bhojwani, Deepa, Brown, Patrick A., Pulsipher, Michael A., Rheingold, Susan R., Gardner, Rebecca A., Shah, Nirali N.

“…•The presence of a KMT2A rearrangement is highly associated with the development of a lineage switch after CD19-CAR.•Outcomes following post–CD19-CAR relapse…”
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Absolute lymphocyte count recovery following initial acute myelogenous leukemia therapy: Implications for adoptive cell therapy by Molina, John C., Li, Yimei, Otto, William R., Miller, Tamara P., Getz, Kelly D., Mccoubrey, Carly, Ramos, Mark, Krause, Edward, Cao, Lusha, Gramatges, M. Monica, Rabin, Karen, Scheurer, Michael, Elgarten, Caitlin W., Myers, Regina M., Seif, Alix E., Fisher, Brian T., Shah, Nirali N., Aplenc, Richard

“…Background An adequate absolute lymphocyte count (ALC) is an essential first step in autologous chimeric antigen receptor (CAR) T‐cell manufacturing. For…”
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Presentation acuity, induction mortality, and resource utilization in infants with acute leukemia by Ibrahimova, Azada, Winestone, Lena E., Miller, Tamara P., Kettler, Kyle, Seif, Alix E., Huang, Yuan‐Shung, Elgarten, Caitlin W., Myers, Regina M., Fisher, Brian T., Aplenc, Richard, Getz, Kelly D.

“…Background Treatment of infants with acute leukemia remains challenging, especially for acute lymphocytic leukemia (ALL). Infants have shown markedly higher…”
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Rachitic Changes, Demineralization, and Fracture Risk in Healthy Infants and Toddlers with Vitamin D Deficiency by PEREZ-ROSSELLO, Jeannette M, FELDMAN, Henry A, KLEINMAN, Paul K, CONNOLLY, Susan A, FAIR, Rick A, MYERS, Regina M, GORDON, Catherine M

“…To examine radiographic findings in children with vitamin D deficiency in comparison with biochemical marker levels and prevalence of fractures. The parents or…”
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