Search Results - "Myers, R. H"

Alternatively spliced tissue factor induces angiogenesis through integrin ligation by van den Berg, Y.W, van den Hengel, L.G, Myers, H.R, Ayachi, O, Jordanova, E, Ruf, W, Spek, C.A, Reitsma, P.H, Bogdanov, V.Y, Versteeg, H.H

“…The initiator of coagulation, full-length tissue factor (flTF), in complex with factor VIIa, influences angiogenesis through PAR-2. Recently, an alternatively…”
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Weight loss in early stage of Huntington's disease by DJOUSSE, L, KNOWLTON, B, CUPPLES, L. A, MARDER, K, SHOULSON, I, MYERS, R. H

“…Huntington's disease (HD) is an autosomal dominant disease with neurologic manifestations. In transgenic mouse models of HD, weight loss is recognized as a…”
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Factors associated with HD CAG repeat instability in Huntington disease by Wheeler, V C, Persichetti, F, McNeil, S M, Mysore, J S, Mysore, S S, MacDonald, M E, Myers, R H, Gusella, J F, Wexler, N S

“…Background:The Huntington disease (HD) CAG repeat exhibits dramatic instability when transmitted to subsequent generations. The instability of the HD disease…”
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Genome Screen for Quantitative Trait Loci Contributing to Normal Variation in Bone Mineral Density: The Framingham Study by Karasik, D., Myers, R. H., Cupples, L. A., Hannan, M. T., Gagnon, D. R., Herbert, A., Kiel, D. P.

“…A genome‐wide scan was performed in a randomly ascertained set of 330 extended families from the population‐based Framingham Study to identify chromosomal…”
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Common Variants in the 5′ Region of the Leptin Gene Are Associated with Body Mass Index in Men from the National Heart, Lung, and Blood Institute Family Heart Study by Jiang, Y., Wilk, J.B., Borecki, I., Williamson, S., DeStefano, A.L., Xu, G., Liu, J., Ellison, R.C., Province, M., Myers, R.H.

“…Linkage of body mass index (BMI) to a broad region of chromosome 7q22-35 has been reported in multiple studies. We previously published a multipoint LOD score…”
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Evidence for association and genetic linkage of the angiotensin-converting enzyme locus with hypertension and blood pressure in men but not women in the Framingham Heart Study by O'DONNELL, C. J, LINDPAINTNER, K, LARSON, M. G, RAO, V. S, ORDOVAS, J. M, SCHAEFER, E. J, MYERS, R. H, LEVY, D

“…There is controversy regarding the association of the angiotensin-converting enzyme deletion-insertion (ACE D/I) polymorphism with systemic hypertension and…”
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Rate of functional decline in Huntington's disease by MARDER, K, ZHAO, H, SHOULSON, I, MYERS, R. H, CUDKOWICZ, M, KAYSON, E, KIEBURTZ, K, ORME, C, PAULSEN, J, PENNEY, J. B, SIEMERS, E

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CAG repeat number governs the development rate of pathology in Huntington's disease by Penney, Jr, J B, Vonsattel, J P, MacDonald, M E, Gusella, J F, Myers, R H

“…We compared the number of CAG repeats, the age at death, and the severity of neuropathology in 89 Huntington's disease brains. We found a linear correlation…”
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BDNF genetic variants are associated with onset age of familial Parkinson disease : GenePD Study by KARAMOHAMED, S, LATOURELLE, J. C, GUTTMAN, M, NICHOLSON, G, WILK, J. B, SAINT-HILAIRE, M, DESTEFANO, A. L, PRAKASH, R, TOBIN, S, WILLIAMSON, J, SUCHOWERSKY, O, LABELL, N, RACETTE, B. A, GROWDON, B. N. J, SINGER, C, WATTS, R, GOLDWURM, S, PEZZOLI, G, BAKER, K. B, GIROUX, M. L, PRAMSTALLER, P. P, BURN, D. J, CHINNERY, P, PERLMUTTER, J. S, SHERMAN, S, VIEREGGE, P, LITVAN, I, GUSELLA, J. F, MYERS, R. H, PARSIAN, A, WOOTEN, G. F, LEW, M, KLEIN, C, SHILL, H, GOLBE, L. I, MARK, M. H

“…Brain-derived neurotrophic factor (BDNF) stimulates neuronal growth and protects nigral dopamine neurons in animal models of Parkinson disease (PD). Therefore,…”
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A genome scan for loci linked to quantitative insulin traits in persons without diabetes: the Framingham Offspring Study by PANHUYSEN, C. I. M, CUPPLES, L. A, WILSON, P. W. F, HERBERT, A. G, MYERS, R. H, MEIGS, J. B

“…Hyperinsulinaemia and insulin resistance usually precede clinical hyperglycaemia and Type 2 diabetes. Thus, plasma insulin concentrations and insulin…”
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NYD-SP18 is associated with obesity in the NHLBI Family Heart Study by Wilk, J.B, Laramie, J.M, Latourelle, J.C, Williamson, S, Nagle, M.W, Tobin, J.E, Foster, C.L, Eckfeldt, J.H, Province, M.A, Borecki, I.B

“…Objective: The NHLBI Family Heart Study (FHS) genome-wide linkage scan identified a region of chromosome 7q with a logarithm of odds score of 4.9 for body mass…”
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Epidemiologic study of 203 sibling pairs with Parkinson's disease: The GenePD study by MAHER, N. E, GOLBE, L. I, FELDMAN, R. G, GUTTMAN, M, LEW, M, SCHUMAN, S, SUCHOWERSKY, O, LAFONTAINE, A. L, LABELLE, N, VIEREGGE, P, PRAMSTALLER, P. P, KLEIN, C, LAZZARINI, A. M, HUBBLE, J, REIDER, C, GROWDON, J, WATTS, R, MONTGOMERY, E, BAKER, K, SINGER, C, STACY, M, MYERS, R. H, MARK, M. H, CURRIE, L. J, WOOTEN, G. F, SAINT-HILAIRE, M, WILK, J. B, VOLCJAK, J, MAHER, J. E

“…To examine patterns of familial aggregation and factors influencing onset age in a sample of siblings with PD. Sibling pairs (n = 203) with PD were collected…”
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Kynurenine pathway abnormalities in Parkinson's disease by OGAWA, T, MATSON, W. R, BEAL, M. F, MYERS, R. H, BIRD, E. D, MILBURY, P, SASO, S

“…We measured metabolites of tyrosine and tryptophan (TRP) in the frontal cortex, putamen (PT), and pars compacta of the substantia nigra (SN) of control and…”
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Heritability of Left Ventricular Mass: The Framingham Heart Study by Post, Wendy S, Larson, Martin G, Myers, Richard H, Galderisi, Maurizio, Levy, Daniel

“…Left ventricular hypertrophy is associated with an increased risk for cardiovascular disease. The known determinants of left ventricular hypertrophy only…”
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Genotype-by-sex interaction in the aetiology of type 2 diabetes mellitus : support for sex-specific quantitative trait loci in Hypertension Genetic Epidemiology Network participants by AVERY, C. L, FREEDMAN, B. I, NORTH, K. E, KRAJA, A. T, BORECKI, I. B, MILLER, M. B, PANKOW, J. S, ARNETT, D, LEWIS, C. E, MYERS, R. H, HUNT, S. C

“…While there are sex-related differences in both the prevalence of type 2 diabetes mellitus and disease risk factors, there is only limited research on…”
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Interaction of normal and expanded CAG repeat sizes influences age at onset of Huntington disease by Djoussé, L., Knowlton, B., Hayden, M., Almqvist, E.W., Brinkman, R., Ross, C., Margolis, R., Rosenblatt, A., Durr, A., Dode, C., Morrison, P.J., Novelletto, A., Frontali, M., Trent, R.J.A., McCusker, E., Gómez-Tortosa, E., Mayo, D., Jones, R., Zanko, A., Nance, M., Abramson, R., Suchowersky, O., Paulsen, J., Harrison, M., Yang, Q., Cupples, L.A., Gusella, J.F., MacDonald, M.E., Myers, R.H.

“…Huntington disease (HD) is a neurodegenerative disorder caused by the abnormal expansion of CAG repeats in the HD gene on chromosome 4p16.3. Past studies have…”
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Circulating MCP-1 levels shows linkage to chemokine receptor gene cluster on chromosome 3: the NHLBI Family Heart Study follow-up examination by Bielinski, S J, Pankow, J S, Miller, M B, Hopkins, P N, Eckfeldt, J H, Hixson, J, Liu, Y, Register, T, Myers, R H, Arnett, D K

“…Atherogenesis is a chronic inflammatory process. Critical in the inflammation process is monocyte chemoattractant protein-1 (MCP-1). To locate genomic regions…”
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Parental age at child's birth and son's risk of prostate cancer : The Framingham study by YUQING ZHANG, KREGER, B. E, DORGAN, J. F, CUPPLES, L. A, MYERS, R. H, SPLANSKY, G. L, SCHATZKIN, A, ELLISON, R. C

“…The authors examined the relation of parental age at birth to the risk of prostate cancer among sons with the use of data from the Framingham Study. During 42…”
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Reduced Penetrance of the Huntington's Disease Mutation by McNeil, Sandra M., Novelletto, Andrea, Srinidhi, Jayalakshmi, Barnes, Glenn, Kornbluth, Ira, Altherr, Michael R., Wasmuth, John J., Gusella, James F., MacDonald, Marcy E., Myers, Richard H.

“…Controversy persists concerning the significance of Huntington disease (HD) alleles in the 36–39 repeat range. Although some clinically affected persons have…”
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De novo expansion of a (CAG) n repeat in sporadic Huntington's disease by Myers, R. H, MacDonald, M. E, Koroshetz, W. J, Duyao, M. P, Ambrose, C. M, Taylor, S. A. M, Barnes, G, Srinidhi, J, Lin, C. S, Whaley, W. L, Lazzarini, A. M, Schwarz, M, Wolff, G, Bird, E. D, Vonsattel, J.-P. G, Gusella, J. F

“…Huntington's disease (HD) chromosomes contain an expanded unstable (CAG)n repeat in chromosome 4p16.3. We have examined nine families with potential de novo…”
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