Search Results - "Myers, James F."

Boosting the diagnostic power of amyloid-β PET using a data-driven spatially informed classifier for decision support by Venkataraman, Ashwin V, Bai, Wenjia, Whittington, Alex, Myers, James F, Rabiner, Eugenii A, Lingford-Hughes, Anne, Matthews, Paul M

“…Amyloid-β (Aβ) PET has emerged as clinically useful for more accurate diagnosis of patients with cognitive decline. Aβ deposition is a necessary cause or…”
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Blunted endogenous opioid release following an oral dexamphetamine challenge in abstinent alcohol-dependent individuals by Turton, Samuel, Myers, James FM, Mick, Inge, Colasanti, Alessandro, Venkataraman, Ashwin, Durant, Claire, Waldman, Adam, Brailsford, Alan, Parkin, Mark C, Dawe, Gemma, Rabiner, Eugenii A, Gunn, Roger N, Lightman, Stafford L, Nutt, David J, Lingford-Hughes, Anne

“…Addiction has been proposed as a ‘reward deficient’ state, which is compensated for with substance use. There is growing evidence of dysregulation in the…”
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Using Baclofen to Explore GABA-B Receptor Function in Alcohol Dependence: Insights From Pharmacokinetic and Pharmacodynamic Measures by Durant, Claire F, Paterson, Louise M, Turton, Sam, Wilson, Susan J, Myers, James F M, Muthukumaraswamy, Suresh, Venkataraman, Ashwin, Mick, Inge, Paterson, Susan, Jones, Tessa, Nahar, Limon K, Cordero, Rosa E, Nutt, David J, Lingford-Hughes, Anne

“…The role of GABA-B neurotransmission in addiction has recently received increased attention, with clinical trials indicating that baclofen, a GABA-B receptor…”
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First evaluation of PET-based human biodistribution and radiation dosimetry of 11C-BU99008, a tracer for imaging the imidazoline2 binding site by Venkataraman, Ashwin V., Keat, Nicholas, Myers, James F., Turton, Samuel, Mick, Inge, Gunn, Roger N., Rabiner, Eugenii A., Passchier, Jan, Parker, Christine A., Tyacke, Robin J., Nutt, David J.

“…Background We measured whole body distribution of 11 C-BU99008, a new PET biomarker for non-invasive identification of the imidazoline 2 binding site. The…”
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γ-aminobutyric acid as a metabolite: Interpreting magnetic resonance spectroscopy experiments by Myers, James FM, Nutt, David J, Lingford-Hughes, Anne R

“…The current rise in the prevalence of magnetic resonance spectroscopy experiments to measure γ-aminobutyric acid in the living human brain is an exciting and…”
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Characterisation of the Contribution of the GABA-Benzodiazepine α1 Receptor Subtype to [11C]Ro15-4513 PET Images by Myers, James FM, Rosso, Lula, Watson, Ben J, Wilson, Sue J, Kalk, Nicola J, Clementi, Nicoletta, Brooks, David J, Nutt, David J, Turkheimer, Federico E, Lingford-Hughes, Anne R

“…This positron emission tomography (PET) study aimed to further define selectivity of [11C]Ro15-4513 binding to the GABARα5 relative to the GABARα1…”
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Decreased GABA-A Receptor Binding in Association With β-Lactam Antibiotic Use by Flaus, Anthime, Riaño Barros, Daniela Alexandra, Hinz, Rainer, Myers, James F, Lingford-Hughes, Anne, Koepp, Matthias J, Hammers, Alexander, McGinnity, Colm Joseph

“…ABSTRACTβ-Lactam antibiotics are proconvulsive. In laboratory animals, this effect seems to be predominantly mediated through inhibition of GABA-A receptors,…”
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Investigating expectation and reward in human opioid addiction with [11C]raclopride PET by Watson, Ben J., Taylor, Lindsay G., Reid, Alastair G., Wilson, Sue J., Stokes, Paul R., Brooks, David J., Myers, James F., Turkheimer, Federico E., Nutt, David J., Lingford-Hughes, Anne R.

“…The rewarding properties of some abused drugs are thought to reside in their ability to increase striatal dopamine levels. Similar increases have been shown in…”
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Characterisation of the contribution of the GABA-benzodiazepine alpha 1 receptor subtype to [ super(11)C]Ro15-4513 PET images by Myers, James FM, Rosso, Lula, Watson, Ben J, Wilson, Sue J, Kalk, Nicola J, Clementi, Nicoletta, Brooks, David J, Nutt, David J, Turkheimer, Federico E, Lingford-Hughes, Anne R

“…This positron emission tomography (PET) study aimed to further define selectivity of [ super(11)C]Ro15-4513 binding to the GABAR alpha 5 relative to the GABAR…”
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Measurement of GABA using J-difference edited 1H-MRS following modulation of synaptic GABA concentration with tiagabine by Myers, James F.M., Evans, C. John, Kalk, Nicola J., Edden, Richard A.E., Lingford-Hughes, Anne R.

“…ABSTRACT Though GABA is the major inhibitory neurotransmitter in the brain, involved in a wide variety of brain functions and many neuropsychiatric disorders,…”
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Exploratory study of associations between monetary reward anticipation brain responses and mu-opioid signalling in alcohol dependence, gambling disorder and healthy controls by Turton, Samuel, Paterson, Louise M., Myers, James FM, Mick, Inge, Lan, Chen-Chia, McGonigle, John, Bowden-Jones, Henrietta, Clark, Luke, Nutt, David J., Lingford-Hughes, Anne R.

“…Alcohol dependence (AD) and gambling disorder (GD) are common addiction disorders with significant physical and mental health consequences. AD and GD are…”
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Boosting the diagnostic power of amyloid-[beta] PET using a data-driven spatially informed classifier for decision support by Venkataraman, Ashwin V, Bai, Wenjia, Whittington, Alex, Myers, James F, Rabiner, Eugenii A, Lingford-Hughes, Anne, Matthews, Paul M

“…Background Amyloid-[beta] (A[beta]) PET has emerged as clinically useful for more accurate diagnosis of patients with cognitive decline. A[beta] deposition is…”
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Αlpha 5 subunit-containing GABAA receptors in temporal lobe epilepsy with normal MRI by McGinnity, Colm J, Riaño Barros, Daniela A, Hinz, Rainer, Myers, James F, Yaakub, Siti N, Thyssen, Charlotte, Heckemann, Rolf A, de Tisi, Jane, Duncan, John S, Sander, Josemir W, Lingford-Hughes, Anne, Koepp, Matthias J, Hammers, Alexander

“…Abstract GABAA receptors containing the α5 subunit mediate tonic inhibition and are widely expressed in the limbic system. In animals, activation of…”
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Αlpha 5 subunit-containing GABA A receptors in temporal lobe epilepsy with normal MRI by McGinnity, Colm J, Riaño Barros, Daniela A, Hinz, Rainer, Myers, James F, Yaakub, Siti N, Thyssen, Charlotte, Heckemann, Rolf A, de Tisi, Jane, Duncan, John S, Sander, Josemir W, Lingford-Hughes, Anne, Koepp, Matthias J, Hammers, Alexander

“…GABA receptors containing the α5 subunit mediate tonic inhibition and are widely expressed in the limbic system. In animals, activation of α5-containing…”
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Decreased GABA-A Receptor Binding in Association With β-Lactam Antibiotic Use by Flaus, Anthime, Riaño Barros, Daniela Alexandra, Hinz, Rainer, Myers, James F, Lingford-Hughes, Anne, Koepp, Matthias J, Hammers, Alexander, McGinnity, Colm Joseph

“…β-Lactam antibiotics are proconvulsive. In laboratory animals, this effect seems to be predominantly mediated through inhibition of GABA-A receptors, but it…”
Get full text

First evaluation of PET-based human biodistribution and radiation dosimetry of 11 C-BU99008, a tracer for imaging the imidazoline 2 binding site by Venkataraman, Ashwin V, Keat, Nicholas, Myers, James F, Turton, Samuel, Mick, Inge, Gunn, Roger N, Rabiner, Eugenii A, Passchier, Jan, Parker, Christine A, Tyacke, Robin J, Nutt, David J

“…We measured whole body distribution of C-BU99008, a new PET biomarker for non-invasive identification of the imidazoline binding site. The purpose of this…”
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aminobutyric acid as a metabolite: Interpreting magnetic resonance spectroscopy experiments by Myers, James FM, Nutt, David J, Lingford-Hughes, Anne R

“…The current rise in the prevalence of magnetic resonance spectroscopy experiments to measure ...-aminobutyric acid in the living human brain is an exciting and…”
Get full text

Measurement of GABA using J-difference edited super(1)H-MRS following modulation of synaptic GABA concentration with tiagabine by Myers, James FM, Evans, CJohn, Kalk, Nicola J, Edden, Richard AE, Lingford-Hughes, Anne R

“…Though GABA is the major inhibitory neurotransmitter in the brain, involved in a wide variety of brain functions and many neuropsychiatric disorders, its…”
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Dysthymic and hypomanic self-referent effects associated with depressive illness and recovery by Myers, James F., Lynch, Patrick B., Bakal, Donald A.

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