Search Results - "Myers, Chris"
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Advancing reuse of genetic parts: progress and remaining challenges
Published in Nature communications (23-05-2023)“…Issues with data reuse have been recognized in synthetic biology and the broader scientific community. Policies and standards fall short as machine reasoning…”
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Engineering genetic circuits: advancements in genetic design automation tools and standards for synthetic biology
Published in Current opinion in microbiology (01-08-2022)“…Synthetic biology (SynBio) is a field at the intersection of biology and engineering. Inspired by engineering principles, researchers use defined parts to…”
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Evaluating the Contribution of Model Complexity in Predicting Robustness in Synthetic Genetic Circuits
Published in ACS synthetic biology (20-09-2024)“…The design–build–test–learn workflow is pivotal in synthetic biology as it seeks to broaden access to diverse levels of expertise and enhance circuit…”
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Genetic circuit design automation with Cello 2.0
Published in Nature protocols (01-04-2022)“…Cells interact with their environment, communicate among themselves, track time and make decisions through functions controlled by natural regulatory genetic…”
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Optimization of affinity, specificity and function of designed influenza inhibitors using deep sequencing
Published in Nature biotechnology (01-06-2012)“…To increase the affinity of designed protein inhibitors for influenza hemagglutinin, Whitehead et al . use yeast display and deep sequencing to measure the…”
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PhageBox: An Open Source Digital Microfluidic Extension With Applications for Phage Discovery
Published in IEEE transactions on biomedical engineering (01-01-2024)“…Objective: Recent advancements demonstrate the significant role of digital microfluidics in automating laboratory work with DNA and on-site viral testing…”
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Sequence-Based Searching for SynBioHub Using VSEARCH
Published in ACS synthetic biology (18-02-2022)“…The ability to search for a part by its sequence is crucial for a large repository of parts. Prior to this work, however, this was not possible on SynBioHub…”
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The Systems Biology Markup Language (SBML): Language Specification for Level 3 Version 2 Core Release 2
Published in Journal of integrative bioinformatics (20-06-2019)“…Computational models can help researchers to interpret data, understand biological functions, and make quantitative predictions. The Systems Biology Markup…”
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SBOL Visual: A Graphical Language for Genetic Designs
Published in PLoS biology (01-12-2015)“…Synthetic Biology Open Language (SBOL) Visual is a graphical standard for genetic engineering. It consists of symbols representing DNA subsequences, including…”
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SBOLCanvas: A Visual Editor for Genetic Designs
Published in ACS synthetic biology (16-07-2021)“…SBOLCanvas is a web-based application that can create and edit genetic constructs using the SBOL data and visual standards. SBOLCanvas allows a user to create…”
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SeqImprove: Machine-Learning-Assisted Curation of Genetic Circuit Sequence Information
Published in ACS synthetic biology (20-09-2024)“…The progress and utility of synthetic biology is currently hindered by the lengthy process of studying literature and replicating poorly documented work…”
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SynBioHub: A Standards-Enabled Design Repository for Synthetic Biology
Published in ACS synthetic biology (16-02-2018)“…The SynBioHub repository (https://synbiohub.org) is an open-source software project that facilitates the sharing of information about engineered biological…”
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Complex Thermodynamic Behavior of Single-Stranded Nucleic Acid Adsorption to Graphene Surfaces
Published in Langmuir (21-06-2016)“…In just over a decade since its discovery, research on graphene has exploded due to a number of potential applications in electronics, materials, and medicine…”
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Design of Asynchronous Genetic Circuits
Published in Proceedings of the IEEE (01-07-2019)“…Most digital electronic circuits utilize a timing reference to synchronize the progression of signals and enable sequential memory elements. These designs may…”
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Investigating and Modeling the Factors That Affect Genetic Circuit Performance
Published in ACS synthetic biology (17-11-2023)“…Over the past 2 decades, synthetic biology has yielded ever more complex genetic circuits that are able to perform sophisticated functions in response to…”
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Synthetic Biology Curation Tools (SYNBICT)
Published in ACS synthetic biology (19-11-2021)“…Much progress has been made in developing tools to generate component-based design representations of biological systems from standard libraries of parts. Most…”
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SBOLDesigner 2: An Intuitive Tool for Structural Genetic Design
Published in ACS synthetic biology (21-07-2017)“…As the Synthetic Biology Open Language (SBOL) data and visual standards gain acceptance for describing genetic designs in a detailed and reproducible way,…”
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The Systems Biology Markup Language (SBML): Language Specification for Level 3 Version 2 Core
Published in Journal of integrative bioinformatics (09-03-2018)“…Computational models can help researchers to interpret data, understand biological functions, and make quantitative predictions. The Systems Biology Markup…”
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A Comparison of Weighted Stochastic Simulation Methods for the Analysis of Genetic Circuits
Published in ACS synthetic biology (20-01-2023)“…Rare events are of particular interest in synthetic biology because rare biochemical events may be catastrophic to a biological system by, for example,…”
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SBOLExplorer: Data Infrastructure and Data Mining for Genetic Design Repositories
Published in ACS synthetic biology (18-10-2019)“…This paper describes SBOLExplorer, a system that is used to provide intuitive searching within the SynBioHub genetic design repository. SynBioHub stores…”
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