Search Results - "Myasnikov, Alexander G."

Structure of the human TRPM4 ion channel in a lipid nanodisc by Autzen, Henriette E, Myasnikov, Alexander G, Campbell, Melody G, Asarnow, Daniel, Julius, David, Cheng, Yifan

“…Transient receptor potential (TRP) melastatin 4 (TRPM4) is a widely expressed cation channel associated with a variety of cardiovascular disorders. TRPM4 is…”
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Structure of Hsp90–Hsp70–Hop–GR reveals the Hsp90 client-loading mechanism by Wang, Ray Yu-Ruei, Noddings, Chari M., Kirschke, Elaine, Myasnikov, Alexander G., Johnson, Jill L., Agard, David A.

“…Maintaining a healthy proteome is fundamental for the survival of all organisms 1 . Integral to this are Hsp90 and Hsp70, molecular chaperones that together…”
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Structural Basis for NusA Stabilized Transcriptional Pausing by Guo, Xieyang, Myasnikov, Alexander G., Chen, James, Crucifix, Corinne, Papai, Gabor, Takacs, Maria, Schultz, Patrick, Weixlbaumer, Albert

“…Transcriptional pausing by RNA polymerases (RNAPs) is a key mechanism to regulate gene expression in all kingdoms of life and is a prerequisite for…”
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eIF2B-catalyzed nucleotide exchange and phosphoregulation by the integrated stress response by Kenner, Lillian R, Anand, Aditya A, Nguyen, Henry C, Myasnikov, Alexander G, Klose, Carolin J, McGeever, Lea A, Tsai, Jordan C, Miller-Vedam, Lakshmi E, Walter, Peter, Frost, Adam

“…The integrated stress response (ISR) tunes the rate of protein synthesis. Control is exerted by phosphorylation of the general translation initiation factor…”
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Structural insights into the regulation of human serine palmitoyltransferase complexes by Wang, Yingdi, Niu, Yiming, Zhang, Zhe, Gable, Kenneth, Gupta, Sita D., Somashekarappa, Niranjanakumari, Han, Gongshe, Zhao, Hongtu, Myasnikov, Alexander G., Kalathur, Ravi C., Dunn, Teresa M., Lee, Chia-Hsueh

“…Sphingolipids are essential lipids in eukaryotic membranes. In humans, the first and rate-limiting step of sphingolipid synthesis is catalyzed by the serine…”
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eIF3 Peripheral Subunits Rearrangement after mRNA Binding and Start-Codon Recognition by Simonetti, Angelita, Brito Querido, Jailson, Myasnikov, Alexander G., Mancera-Martinez, Eder, Renaud, Adeline, Kuhn, Lauriane, Hashem, Yaser

“…mRNA translation initiation in eukaryotes requires the cooperation of a dozen eukaryotic initiation factors (eIFs) forming several complexes, which leads to…”
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Allosteric coupling between α-rings of the 20S proteasome by Yu, Zanlin, Yu, Yadong, Wang, Feng, Myasnikov, Alexander G., Coffino, Philip, Cheng, Yifan

“…Proteasomal machinery performs essential regulated protein degradation in eukaryotes. Classic proteasomes are symmetric, with a regulatory ATPase docked at…”
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Structural basis of early translocation events on the ribosome by Rundlet, Emily J., Holm, Mikael, Schacherl, Magdalena, Natchiar, S. Kundhavai, Altman, Roger B., Spahn, Christian M. T., Myasnikov, Alexander G., Blanchard, Scott C.

“…Peptide-chain elongation during protein synthesis entails sequential aminoacyl-tRNA selection and translocation reactions that proceed rapidly (2–20 per…”
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Structure–function insights reveal the human ribosome as a cancer target for antibiotics by Myasnikov, Alexander G., Kundhavai Natchiar, S., Nebout, Marielle, Hazemann, Isabelle, Imbert, Véronique, Khatter, Heena, Peyron, Jean-François, Klaholz, Bruno P.

“…Many antibiotics in clinical use target the bacterial ribosome by interfering with the protein synthesis machinery. However, targeting the human ribosome in…”
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Focused classification and refinement in high-resolution cryo-EM structural analysis of ribosome complexes by von Loeffelholz, Ottilie, Natchiar, S Kundhavai, Djabeur, Nadia, Myasnikov, Alexander G, Kratzat, Hanna, Ménétret, Jean-François, Hazemann, Isabelle, Klaholz, Bruno P

“…[Display omitted] •Direct electron detectors, structure sorting and focused refinement.•Cryo-EM structures of the ribosome heading towards atomic…”
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Structure of the transcription activator target Tra1 within the chromatin modifying complex SAGA by Sharov, Grigory, Voltz, Karine, Durand, Alexandre, Kolesnikova, Olga, Papai, Gabor, Myasnikov, Alexander G., Dejaegere, Annick, Ben Shem, Adam, Schultz, Patrick

“…The transcription co-activator complex SAGA is recruited to gene promoters by sequence-specific transcriptional activators and by chromatin modifications to…”
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Directed evolution of the rRNA methylating enzyme Cfr reveals molecular basis of antibiotic resistance by Tsai, Kaitlyn, Stojković, Vanja, Noda-Garcia, Lianet, Young, Iris D, Myasnikov, Alexander G, Kleinman, Jordan, Palla, Ali, Floor, Stephen N, Frost, Adam, Fraser, James S, Tawfik, Dan S, Fujimori, Danica Galonić

“…Alteration of antibiotic binding sites through modification of ribosomal RNA (rRNA) is a common form of resistance to ribosome-targeting antibiotics. The…”
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Ribosomal 18S rRNA base pairs with mRNA during eukaryotic translation initiation by Martin, Franck, Ménétret, Jean-François, Simonetti, Angelita, Myasnikov, Alexander G., Vicens, Quentin, Prongidi-Fix, Lydia, Natchiar, S. Kundhavai, Klaholz, Bruno P., Eriani, Gilbert

“…Eukaryotic mRNAs often contain a Kozak sequence that helps tether the ribosome to the AUG start codon. The mRNA of histone H4 ( h4 ) does not undergo classical…”
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RbfA Is Involved in Two Important Stages of 30S Subunit Assembly: Formation of the Central Pseudoknot and Docking of Helix 44 to the Decoding Center by Maksimova, Elena M., Korepanov, Alexey P., Kravchenko, Olesya V., Baymukhametov, Timur N., Myasnikov, Alexander G., Vassilenko, Konstantin S., Afonina, Zhanna A., Stolboushkina, Elena A.

“…Ribosome biogenesis is a highly coordinated and complex process that requires numerous assembly factors that ensure prompt and flawless maturation of ribosomal…”
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Structure of the 30S translation initiation complex by Marzi, Stefano, Simonetti, Angelita, Yusupov, Marat, Klaholz, Bruno P, Fabbretti, Attilio, Myasnikov, Alexander G, Gualerzi, Claudio O

“…Translation initiation, the rate-limiting step of the universal process of protein synthesis, proceeds through sequential, tightly regulated steps. In…”
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Purification, characterization and crystallization of the human 80S ribosome by Khatter, Heena, Myasnikov, Alexander G, Mastio, Leslie, Billas, Isabelle M L, Birck, Catherine, Stella, Stefano, Klaholz, Bruno P

“…Ribosomes are key macromolecular protein synthesis machineries in the cell. Human ribosomes have so far not been studied to atomic resolution because of their…”
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Visualizing the Role of 2'-OH rRNA Methylations in the Human Ribosome Structure by Natchiar, S Kundhavai, Myasnikov, Alexander G, Hazemann, Isabelle, Klaholz, Bruno P

“…Chemical modifications of RNA have recently gained new attention in biological sciences. They occur notably on messenger RNA (mRNA) and ribosomal RNA (rRNA)…”
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Involvement of protein IF2 N domain in ribosomal subunit joining revealed from architecture and function of the full-length initiation factor by Simonetti, Angelita, Marzi, Stefano, Billas, Isabelle M. L., Tsai, Albert, Fabbretti, Attilio, Myasnikov, Alexander G., Roblin, Pierre, Vaiana, Andrea C., Hazemann, Isabelle, Eiler, Daniel, Steitz, Thomas A., Puglisi, Joseph D., Gualerzi, Claudio O., Klaholz, Bruno P.

“…Translation initiation factor 2 (IF2) promotes 30S initiation complex (IC) formation and 50S subunit joining, which produces the 70S IC. The architecture of…”
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Visualization of chemical modifications in the human 80S ribosome structure by Natchiar, S. Kundhavai, Myasnikov, Alexander G., Kratzat, Hanna, Hazemann, Isabelle, Klaholz, Bruno P.

“…Chemical modifications of human ribosomal RNA (rRNA) are introduced during biogenesis and have been implicated in the dysregulation of protein synthesis, as is…”
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Structure of the human 80S ribosome by Khatter, Heena, Myasnikov, Alexander G., Natchiar, S. Kundhavai, Klaholz, Bruno P.

“…Ribosomes are translational machineries that catalyse protein synthesis. Ribosome structures from various species are known at the atomic level, but obtaining…”
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