Search Results - "Myöhänen, S"

Methylation-Specific PCR: A Novel PCR Assay for Methylation Status of CpG Islands by Herman, James G., Graff, Jeremy R., Myöhänen, Sanna, Nelkin, Barry D., Baylin, Stephen B.

“…Precise mapping of DNA methylation patterns in CpG islands has become essential for understanding diverse biological processes such as the regulation of…”
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Synergy of demethylation and histone deacetylase inhibition in the re-expression of genes silenced in cancer by Baylin, Stephen B, Cameron, Elizabeth E, Bachman, Kurtis E, Myöhänen, Sanna, Herman, James G

“…Densely methylated DNA associates with transcriptionally repressive chromatin characterized by the presence of underacetylated histones. Recently, these two…”
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Sequence-specific DNA Binding Activity of RNA Helicase A to the p16 Promoter by Myöhänen, Sanna, Baylin, Stephen B.

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Mapping patterns of CpG island methylation in normal and neoplastic cells implicates both upstream and downstream regions in de novo methylation by Graff, J R, Herman, J G, Myöhänen, S, Baylin, S B, Vertino, P M

“…Promoter region CpG island methylation is associated with tumor suppressor gene silencing in neoplasia. GenBank sequence analyses revealed that a number of CpG…”
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Hypermethylation of the APC (adenomatous Polyposis Coli) gene promoter region in human colorectal carcinoma by Hiltunen, Mikko O., Alhonen, Leena, Koistinaho, Jari, Myöhänen, Sanna, Pääkkönen, Matti, Marin, Sinikka, Kosma, Veli‐Matti, Jänne, Juhani

“…Germline mutations of the putative tumor suppressor gene APC are associated in high frequency with the familial adenomatous polyposis, predisposing the…”
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Epigenetics of latent Epstein-Barr virus genomes: high resolution methylation analysis of the bidirectional promoter region of latent membrane protein 1 and 2B genes by Takacs, M, Salamon, D, Myöhänen, S, Li, H, Segesdi, J, Ujvari, D, Uhlig, J, Niller, H H, Wolf, H, Berencsi, G, Minarovits, J

“…We analysed the methylation patterns of CpG dinucleotides in a bidirectional promoter region (LRS, LMP 1 regulatory sequences) of latent Epstein-Barr virus…”
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Hypermethylation of the WT1 and calcitonin gene promoter regions at chromosome 11p in human colorectal cancer by HILTUNEN, M. O, KOISTINAHO, J, ALHONEN, L, MYÖHÄNEN, S, MARIN, S, KOSMA, V.-M, PÄÄKKÖNEN, M, JÄNNE, J

“…The short arm of the chromosome 11, known to harbour a number of putative and established tumour-suppressor genes, is frequently hypermethylated in various…”
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De novo DNA methylation at nonrandom founder sites 5' from an unmethylated minimal origin of DNA replication in latent Epstein-Barr virus genomes by Salamon, D, Takacs, M, Myöhänen, S, Marcsek, Z, Berencsi, G, Minarovits, J

“…Latent episomal genomes of Epstein-Barr virus, a human gammaherpesvirus, represent a suitable model system for studying replication and methylation of…”
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Generation of Transgenic Dairy Cattle from Transgene-Analyzed and Sexed Embryos Produced In Vitro by Hyttinen, Juha-Matti, Peura, Teija, Tolvanen, Minna, Aalto, Jussi, Alhonen, Leena, Sinervirta, Riitta, Halmekytö, Maria, Myöhänen, Sanna, Jänne, Juhani

“…We have generated a transgenic calf from in vitro produced bovine embryos which had undergone transgene analysis and sexing prior to the embryo transfer…”
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Kinds of mutations induced by 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone (MX) in the hprt gene of Chinese hamster ovary cells by Hyttinen, Juha M.T., Myöhänen, Sanna, Jansson, Kristian

“…The kinds of mutations induced by 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone (MX) in the protein coding region of the hprt gene of Chinese hamster…”
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High-level expression of bovine β-lactoglobulin gene in transgenic mice by Hyttinen, Juha-Matti, Korhonen, Veli-Pekka, Hiltunen, Mikko O, Myöhänen, Sanna, Jänne, Juhani

“…To study the expression of the bovine β-lactoglobulin (BLG) gene we isolated the BLG gene from a genomic library and introduced it into murine germline. Bovine…”
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Hypermethylation can selectively silence individual p16ink4A alleles in neoplasia by MYÖHÄNEN, S. K, BAYLIN, S. B, HERMAN, J. G

“…Inactivation of p16ink4A and other tumor suppressor genes has been associated with promoter region hypermethylation in neoplasia. However, direct proof for…”
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Hypermethylation of calcitonin gene regulatory sequences in human breast cancer as revealed by genomic sequencing by Hakkarainen, Mika, Wahlfors, Jarmo, Myöhänen, Sanna, Hiltunen, Mikko O., Eskelinen, Matti, Johansson, Risto, Jänne, Juhani

“…DNA methylation has been studied intensively during the past years in order to elucidate its role in the regulation of gene expression, gene imprinting and…”
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Molecular cloning of a cDNA encoding human spermine synthase by Korhonen, V P, Halmekytö, M, Kauppinen, L, Myöhänen, S, Wahlfors, J, Keinänen, T, Hyvönen, T, Alhonen, L, Eloranta, T, Jänne, J

“…We have isolated and sequenced cDNA clones that encode human spermine synthase (EC 2.5.1.22). The total length of the sequenced cDNA was 1,612 nucleotides,…”
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Automated fluorescent primer extension by Myöhänen, S, Wahlfors, J

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Tissue-specific expression of the diazepam-binding inhibitor in Drosophila melanogaster: cloning, structure, and localization of the gene by Kolmer, M, Roos, C, Tirronen, M, Myoehaenen, S, Alho, H

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Analysis of methylation patterns in the regulatory region of the latent Epstein-Barr virus promoter BCR2 by automated fluorescent genomic sequencing by Takacs, M, Myöhänen, S, Altiok, E, Minarovits, J

“…We analyzed the methylation patterns of CpG dinucleotides in the regulatory region of the latent Epstein-Barrvirus (EBV) promoter BCR2 (also called C promoter,…”
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Transgenic mice aberrantly expressing human ornithine decarboxylase gene by HALMEKYTO, M, HYTTINEN, J.-M, JANNE, J, SINERVIRTA, R, UTRIAINEN, M, MYOHANEN, S, VOIPIO, H.-M, WAHLFORS, J, SYRJANEN, S, SYRJANEN, K, ALHONEN, L

“…We have generated transgenic mice carrying human ornithine decarboxylase gene. Two different transgene constructs were used: (i) a 5'-truncated human ornithine…”
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Transgenic mice over-expressing the human spermidine synthase gene by KAUPPINEN, L, MYÖHÄNEN, S, HALMEKYTÖ, M, ALHONEN, L, JÄNNE, J

“…We have generated a transgenic mouse line harbouring the functional (chromosome-1-derived) human spermidine synthase (EC 2.5.1.16) gene in their genome. The…”
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Sequence-specific DNA Binding Activity of RNA Helicase A to the p16INK4a Promoter by Myöhänen, Sanna, Baylin, Stephen B.

“…p16INK4a is frequently altered in human cancer, often through epigenetically mediated transcriptional silencing. However, little is known about the…”
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