Search Results - "Mwenda, Nkatha"

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    Early Animal Origin of BACE1 APP/Aβ Proteolytic Function

    Early Animal Origin of BACE1 APP/Aβ Proteolytic Function by Langeland, James A, Baumann, Lillian, DeYoung, Eva M, Varella, Raphaela Angelina, Mwenda, Nkatha, Aguirre, Alejandro, Moore, D Blaine

    Published in Biology (Basel, Switzerland) (01-05-2024)
    “…Alzheimer's disease is characterized, in part, by the accumulation of β-amyloid (Aβ) in the brain. Aβ is produced via the proteolysis of APP by BACE1 and…”
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    Rescue of α-synuclein aggregation in Parkinson’s patient neurons by synergistic enhancement of ER proteostasis and protein trafficking

    Rescue of α-synuclein aggregation in Parkinson’s patient neurons by synergistic enhancement of ER proteostasis and protein trafficking by Stojkovska, Iva, Wani, Willayat Y., Zunke, Friederike, Belur, Nandkishore R., Pavlenko, Egor A., Mwenda, Nkatha, Sharma, Karan, Francelle, Laetitia, Mazzulli, Joseph R.

    Published in Neuron (Cambridge, Mass.) (02-02-2022)
    “…Neurodegenerative disorders are characterized by a collapse in proteostasis, as shown by the accumulation of insoluble protein aggregates in the brain…”
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