Search Results - "Mwai, Kennedy"

Distinct kinetics of antibodies to 111 Plasmodium falciparum proteins identifies markers of recent malaria exposure by Yman, Victor, Tuju, James, White, Michael T., Kamuyu, Gathoni, Mwai, Kennedy, Kibinge, Nelson, Asghar, Muhammad, Sundling, Christopher, Sondén, Klara, Murungi, Linda, Kiboi, Daniel, Kimathi, Rinter, Chege, Timothy, Chepsat, Emily, Kiyuka, Patience, Nyamako, Lydia, Osier, Faith H. A., Färnert, Anna

“…Strengthening malaria surveillance is a key intervention needed to reduce the global disease burden. Reliable serological markers of recent malaria exposure…”
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Phagocytosis of Plasmodium falciparum ring-stage parasites predicts protection against malaria by Musasia, Fauzia K., Nkumama, Irene N., Frank, Roland, Kipkemboi, Victor, Schneider, Martin, Mwai, Kennedy, Odera, Dennis O., Rosenkranz, Micha, Fürle, Kristin, Kimani, Domitila, Tuju, James, Njuguna, Patricia, Hamaluba, Mainga, Kapulu, Melissa C., Wardemann, Hedda, Osier, Faith H. A.

“…Ring-infected erythrocytes are the predominant asexual stage in the peripheral circulation but are rarely investigated in the context of acquired immunity…”
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Bi-isotype immunoglobulins enhance antibody-mediated neutrophil activity against Plasmodium falciparum parasites by Ogwang, Rodney, Murugu, Lewis, Nkumama, Irene N, Nyamako, Lydia, Kai, Oscar, Mwai, Kennedy, Murungi, Linda, Idro, Richard, Bejon, Philip, Tuju, James, Kinyanjui, Sam Muchina, Osier, Faith H A

“…Malaria remains a major global health priority, and monoclonal antibodies (mAbs) are emerging as potential new tools to support efforts to control the disease…”
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Seven-year kinetics of RTS, S/AS01-induced anti-CSP antibodies in young Kenyan children by Mugo, Robert M, Mwai, Kennedy, Mwacharo, Jedidah, Shee, Faiz M, Musyoki, Jennifer N, Wambua, Juliana, Otieno, Edward, Bejon, Philip, Ndungu, Francis M

“…RTS,S/AS01, the leading malaria vaccine has been recommended by the WHO for widespread immunization of children at risk. RTS,S/AS01-induced anti-CSP IgG…”
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Age, Spatial, and Temporal Variations in Hospital Admissions with Malaria in Kilifi County, Kenya: A 25-Year Longitudinal Observational Study by Mogeni, Polycarp, Williams, Thomas N, Fegan, Gregory, Nyundo, Christopher, Bauni, Evasius, Mwai, Kennedy, Omedo, Irene, Njuguna, Patricia, Newton, Charles R, Osier, Faith, Berkley, James A, Hammitt, Laura L, Lowe, Brett, Mwambingu, Gabriel, Awuondo, Ken, Mturi, Neema, Peshu, Norbert, Snow, Robert W, Noor, Abdisalan, Marsh, Kevin, Bejon, Philip

“…Encouraging progress has been seen with reductions in Plasmodium falciparum malaria transmission in some parts of Africa. Reduced transmission might lead to…”
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Hepcidin regulation in Kenyan children with severe malaria and non-typhoidal Salmonella bacteremia by Abuga, Kelvin M, Muriuki, John Muthii, Uyoga, Sophie M, Mwai, Kennedy, Makale, Johnstone, Mogire, Reagan M, Macharia, Alex W, Mohammed, Shebe, Muthumbi, Esther, Mwarumba, Salim, Mturi, Neema, Bejon, Philip, Scott, J Anthony G, Nairz, Manfred, Williams, Thomas N, Atkinson, Sarah H

“…Malaria and invasive non-typhoidal Salmonella (NTS) are life-threatening infections that often co-exist in African children. The iron-regulatory hormone…”
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Malaria attributable fractions with changing transmission intensity: Bayesian latent class vs logistic models by Mwai, Kennedy, Nkumama, Irene, Thairu, Amos, Mburu, James, Odera, Dennis, Kimathi, Rinter, Nyamako, Lydia, Tuju, James, Kinyanjui, Samson, Musenge, Eustasius, Osier, Faith

“…Abstract Background Asymptomatic carriage of malaria parasites is common in high transmission intensity areas and confounds clinical case definitions for…”
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A space-time analysis of recurrent malnutrition-related hospitalisations in Kilifi, Kenya for children under-5 years by Wambui, Kennedy Mwai, Musenge, Eustasius

“…Globally, malnutrition underlies 45% of under-5 s mortality, mainly from potentiating common infections such as diarrhoea and pneumonia. Malnutrition as a…”
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Characterization of Naturally Acquired Immunity to a Panel of Antigens Expressed in Mature P. falciparum Gametocytes by Muthui, Michelle K, Takashima, Eizo, Omondi, Brian R, Kinya, Christine, Muasya, William I, Nagaoka, Hikaru, Mwai, Kennedy W, Orindi, Benedict, Wambua, Juliana, Bousema, Teun, Drakeley, Chris, Blagborough, Andrew M, Marsh, Kevin, Bejon, Philip, Kapulu, Melissa C

“…Naturally acquired immune responses against antigens expressed on the surface of mature gametocytes develop in individuals living in malaria-endemic areas…”
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Characterization of Anopheles gambiae D7 salivary proteins as markers of human-mosquito bite contact by Oseno, Brenda, Marura, Faith, Ogwang, Rodney, Muturi, Martha, Njunge, James, Nkumama, Irene, Mwakesi, Robert, Mwai, Kennedy, Rono, Martin K, Mwakubambanya, Ramadhan, Osier, Faith, Tuju, James

“…Malaria is transmitted when infected Anopheles mosquitoes take a blood meal. During this process, the mosquitoes inject a cocktail of bioactive proteins that…”
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Age-dependent acquisition of IgG antibodies to Shigella serotypes-a retrospective analysis of seroprevalence in Kenyan children with implications for infant vaccination by Kapulu, Melissa C, Muthumbi, Esther, Otieno, Edward, Rossi, Omar, Ferruzzi, Pietro, Necchi, Francesca, Acquaviva, Alessandra, Martin, Laura B, Orindi, Benedict, Mwai, Kennedy, Kibet, Hillary, Mwanzu, Alfred, Bigogo, Godfrey M, Verani, Jennifer R, Mbae, Cecilia, Nyundo, Christopher, Agoti, Charles N, Nakakana, Usman Nasir, Conti, Valentino, Bejon, Philip, Kariuki, Samuel, Scott, J Anthony G, Micoli, Francesca, Podda, Audino

“…Shigellosis mainly affects children under 5 years of age living in low- and middle-income countries, who are the target population for vaccination. There are,…”
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Serum immunoglobulin G and mucosal immunoglobulin A antibodies from prepandemic samples collected in Kilifi, Kenya, neutralize SARS-CoV-2 in vitro by Nyagwange, James, Kutima, Bernadette, Mwai, Kennedy, Karanja, Henry K., Gitonga, John N., Mugo, Daisy, Sein, Yiakon, Wright, Daniel, Omuoyo, Donwilliams O., Nyiro, Joyce U., Tuju, James, Nokes, D. James, Agweyu, Ambrose, Bejon, Philip, Ochola-Oyier, Lynette I., Scott, J． Anthony G., Lambe, Teresa, Nduati, Eunice, Agoti, Charles, Warimwe, George M.

“…•SARS-CoV-2 spike reactive serum immunoglobulin G antibodies are present in prepandemic samples.•SARS-CoV-2 spike reactive mucosal immunoglobulin A antibodies…”
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Characterization of a novel Plasmodium falciparum merozoite surface antigen and potential vaccine target by Niaré, Karamoko, Chege, Timothy, Rosenkranz, Micha, Mwai, Kennedy, Saßmannshausen, Zoe, Odera, Dennis, Nyamako, Lydia, Tuju, James, Alfred, Tiono, Waitumbi, John N, Ogutu, Bernhards, Sirima, Sodiomon B, Awandare, Gordon, Kouriba, Bourema, Rayner, Julian C, Osier, Faith H A

“…Detailed analyses of genetic diversity, antigenic variability, protein localization and immunological responses are vital for the prioritization of novel…”
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KILchip v1.0: A Novel Plasmodium falciparum Merozoite Protein Microarray to Facilitate Malaria Vaccine Candidate Prioritization by Kamuyu, Gathoni, Tuju, James, Kimathi, Rinter, Mwai, Kennedy, Mburu, James, Kibinge, Nelson, Chong Kwan, Marisa, Hawkings, Sam, Yaa, Reuben, Chepsat, Emily, Njunge, James M, Chege, Timothy, Guleid, Fatuma, Rosenkranz, Micha, Kariuki, Christopher K, Frank, Roland, Kinyanjui, Samson M, Murungi, Linda M, Bejon, Philip, Färnert, Anna, Tetteh, Kevin K A, Beeson, James G, Conway, David J, Marsh, Kevin, Rayner, Julian C, Osier, Faith H A

“…Passive transfer studies in humans clearly demonstrated the protective role of IgG antibodies against malaria. Identifying the precise parasite antigens that…”
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protGear: A protein microarray data pre-processing suite by Mwai, Kennedy, Kibinge, Nelson, Tuju, James, Kamuyu, Gathoni, Kimathi, Rinter, Mburu, James, Chepsat, Emily, Nyamako, Lydia, Chege, Timothy, Nkumama, Irene, Kinyanjui, Samson, Musenge, Eustasius, Osier, Faith

“…[Display omitted] Protein microarrays are versatile tools for high throughput study of the human proteome, but systematic and non-systematic sources of bias…”
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Gametocyte carriage in an era of changing malaria epidemiology: A 19-year analysis of a malaria longitudinal cohort by Muthui, Michelle K., Mogeni, Polycarp, Mwai, Kennedy, Nyundo, Christopher, Macharia, Alex, Williams, Thomas N., Nyangweso, George, Wambua, Juliana, Mwanga, Daniel, Marsh, Kevin, Bejon, Philip, Kapulu, Melissa C.

“…Background: Interventions to block malaria transmission from humans to mosquitoes are currently in development. To be successfully implemented, key populations…”
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Breadth of Fc-mediated effector function correlates with clinical immunity following human malaria challenge by Nkumama, Irene N, Ogwang, Rodney, Odera, Dennis, Musasia, Fauzia, Mwai, Kennedy, Nyamako, Lydia, Murungi, Linda, Tuju, James, Fürle, Kristin, Rosenkranz, Micha, Kimathi, Rinter, Njuguna, Patricia, Hamaluba, Mainga, Kapulu, Melissa C, Frank, Roland, Osier, Faith H A

“…Malaria is a life-threatening disease of global health importance, particularly in sub-Saharan Africa. The growth inhibition assay (GIA) is routinely used to…”
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Antibodies to PfEMP1 and variant surface antigens: Protection after controlled human malaria infection in semi-immune Kenyan adults by Kinyua, Ann W., Turner, Louise, Kimingi, Hannah W., Mwai, Kennedy, Mwikali, Kioko, Andisi, Cheryl, Sim, B. Kim Lee, Bejon, Philip, Kapulu, Melissa C., Kinyanjui, Samson M., Lavstsen, Thomas, Abdi, Abdirahman I.

“…Acquisition of antibodies to Plasmodium falciparum variant surface antigens (VSA) expressed on infected red blood cells (iRBCs) is associated with naturally…”
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Anti-merozoite antibodies induce natural killer cell effector function and are associated with immunity against malaria by Odera, Dennis O, Tuju, James, Mwai, Kennedy, Nkumama, Irene N, Fürle, Kristin, Chege, Timothy, Kimathi, Rinter, Diehl, Stefan, Musasia, Fauzia K, Rosenkranz, Micha, Njuguna, Patricia, Hamaluba, Mainga, Kapulu, Melissa C, Frank, Roland, Osier, Faith H A, Abdi, Abdirahman I, Chi, Primus Che, de Laurent, Zaydah, Jao, Irene, Kamuya, Dorcas, Kamuyu, Gathoni, Makale, Johnstone, Murungi, Linda, Musyoki, Jennifer, Muthui, Michelle, Mwacharo, Jedidah, Kariuki, Silvia, Mwanga, Daniel, Mwongeli, Joyce, Ndungu, Francis, Njue, Maureen, Nyangweso, George, Kimani, Domitila, Ngoi, Joyce M, Musembi, Janet, Ngoto, Omar, Otieno, Edward, Ooko, Michael, Shangala, Jimmy, Wambua, Juliana, Mohammed, Khadija Said, Omuoyo, Donwilliams, Mosobo, Moses, Kibinge, Nelson, Kinyanjui, Sam, Bejon, Philip, Lowe, Brett, Marsh, Kevin, Marsh, Vicki, Abebe, Yonas, Billingsley, Peter F, Sim, Betty Kim Lee, Hoffman, Stephen L, James, Eric R, Richie, Thomas L, Audi, Agnes, Olewe, Fredrick, Oloo, James, Ongecha, John, Ongas, Martin O, Koskei, Nelly, Bull, Peter C, Hodgson, Susanne H, Kivisi, Cheryl, Imwong, Mallika, Murphy, Sean C, Ogutu, Bernhards, Tarning, Joel, Winterberg, Markus, Williams, Thomas N

“…Natural killer (NK) cells are potent immune effectors that can be activated via antibody-mediated Fc receptor engagement. Using multiparameter flow cytometry,…”
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Comparative performance of WANTAI ELISA for total immunoglobulin to receptor binding protein and an ELISA for IgG to spike protein in detecting SARS-CoV-2 antibodies in Kenyan populations by Nyagwange, James, Kutima, Bernadette, Mwai, Kennedy, Karanja, Henry K., Gitonga, John N., Mugo, Daisy, Uyoga, Sophie, Tuju, James, Ochola-Oyier, Lynette I., Ndungu, Francis, Bejon, Philip, Agweyu, Ambrose, Adetifa, Ifedayo M.O., Scott, J.Anthony G., Warimwe, George M.

“…•Both assays discriminate SARS-CoV-2 seropositive and seronegative individuals.•Both assays correctly estimate seroprevalence in a wide range of…”
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