Search Results - "Muzikant, A L"

Magnetic resonance myocardial fiber-orientation mapping with direct histological correlation by Hsu, E W, Muzikant, A L, Matulevicius, S A, Penland, R C, Henriquez, C S

“…Functional properties of the myocardium are mediated by the tissue structure. Consequently, proper physiological studies and modeling necessitate a precise…”
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Influence of transmural repolarization gradients on the electrophysiology and pharmacology of ventricular myocardium. Cellular basis for the Brugada and long–QT syndromes by Antzelevitch, C., Nesterenko, V. V., Muzikant, A. L., Rice, J. J., Chen, G., Colatsky, T.

“…Ventricular myocardium comprises at least three electrophysiologically distinct cell types: epicardial, endocardial and M cells. Epicardial and M cells, but…”
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Bipolar stimulation of a three-dimensional bidomain incorporating rotational anisotropy by Muzikant, A.L., Henriquez, C.S.

“…A bidomain model of cardiac tissue was used to examine the effect of transmural fiber rotation during bipolar stimulation in three-dimensional (3-D)…”
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Validation of three-dimensional conduction models using experimental mapping: are we getting closer? by Muzikant, A.L., Henriquez, C.S.

“…The anisotropic material properties, irregular geometry, and specialized conduction system of the heart all affect the three-dimensional (3D) spread of…”
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Anisotropy, fiber curvature, and bath loading effects on activation in thin and thick cardiac tissue preparations: simulations in a three-dimensional bidomain model by Henriquez, C S, Muzikant, A L, Smoak, C K

“…A modeling study is presented to explore the effects of tissue conductivity, fiber orientation, and presence of an adjoining extracellular volume conductor on…”
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Paced activation mapping reveals organization of myocardial fibers: a simulation study by Muzikant, A L, Henriquez, C S

“…A three-dimensional bidomain model of a block section of both the right and left ventricular walls that included rotational anisotropy and fiber curvature was…”
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Region specific modeling of cardiac muscle: comparison of simulated and experimental potentials by Muzikant, Adam L, Hsu, Edward W, Wolf, Patrick D, Henriquez, Craig S

“…This article investigates the quantitative predictive capabilities of region-specific models by comparing experimental electrograms obtained from in vivo…”
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Models for profiling the potential QT prolongation risk of drugs by Muzikant, Adam L, Penland, R Christian

“…The appearance of QT prolongation and arrhythmic events associated with a compound undergoing clinical trials can greatly hamper drug development programs…”
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