Search Results - "Muzi Falconi, Marco"

One, No One, and One Hundred Thousand: The Many Forms of Ribonucleotides in DNA by Nava, Giulia Maria, Grasso, Lavinia, Sertic, Sarah, Pellicioli, Achille, Muzi Falconi, Marco, Lazzaro, Federico

“…In the last decade, it has become evident that RNA is frequently found in DNA. It is now well established that single embedded ribonucleoside monophosphates…”
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DNA Nucleotide Excision Repair-Dependent Signaling to Checkpoint Activation by Marini, Federica, Nardo, Tiziana, Giannattasio, Michele, Minuzzo, Mario, Stefanini, Miria, Plevani, Paolo, Falconi, Marco Muzi

“…Eukaryotic cells respond to a variety of DNA insults by triggering a common signal transduction cascade, known as checkpoint response, which temporarily halts…”
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Roles and regulation of Haspin kinase and its impact on carcinogenesis by Quadri, Roberto, Sertic, Sarah, Muzi-Falconi, Marco

“…Cancer therapy is based on the selective clearance of malignant cells without severely damaging healthy tissues, and current clinical practice is constantly in…”
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Histone methyltransferase Dot1 and Rad9 inhibit single-stranded DNA accumulation at DSBs and uncapped telomeres by Lazzaro, Federico, Sapountzi, Vasileia, Granata, Magda, Pellicioli, Achille, Vaze, Moreshwar, Haber, James E, Plevani, Paolo, Lydall, David, Muzi-Falconi, Marco

“…Cells respond to DNA double‐strand breaks (DSBs) and uncapped telomeres by recruiting checkpoint and repair factors to the site of lesions. Single‐stranded DNA…”
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Mutations in the mitochondrial protease gene AFG3L2 cause dominant hereditary ataxia SCA28 by Taroni, Franco, Di Bella, Daniela, Lazzaro, Federico, Brusco, Alfredo, Plumari, Massimo, Battaglia, Giorgio, Pastore, Annalisa, Finardi, Adele, Cagnoli, Claudia, Tempia, Filippo, Frontali, Marina, Veneziano, Liana, Sacco, Tiziana, Boda, Enrica, Brussino, Alessandro, Bonn, Florian, Castellotti, Barbara, Baratta, Silvia, Mariotti, Caterina, Gellera, Cinzia, Fracasso, Valentina, Magri, Stefania, Langer, Thomas, Plevani, Paolo, Di Donato, Stefano, Muzi-Falconi, Marco

“…Franco Taroni and colleagues report the identification of mutations in AFG3L2 that cause dominant spinocerebellar ataxia type 28. Along with paraplegin, AFG3L2…”
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Tau and DNA Damage in Neurodegeneration by Colnaghi, Luca, Rondelli, Diego, Muzi-Falconi, Marco, Sertic, Sarah

“…Neurodegenerative disorders are a family of incurable conditions. Among them, Alzheimer's disease and tauopathies are the most common. Pathological features of…”
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Reduction of hRNase H2 activity in Aicardi-Goutières syndrome cells leads to replication stress and genome instability by Pizzi, Sara, Sertic, Sarah, Orcesi, Simona, Cereda, Cristina, Bianchi, Marika, Jackson, Andrew P, Lazzaro, Federico, Plevani, Paolo, Muzi-Falconi, Marco

“…Aicardi-Goutières syndrome (AGS) is an inflammatory encephalopathy caused by defective nucleic acids metabolism. Over 50% of AGS mutations affect RNase H2 the…”
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Phosphorylation of H3-Thr3 by Haspin Is Required for Primary Cilia Regulation by Quadri, Roberto, Sertic, Sarah, Ghilardi, Anna, Rondelli, Diego, Gallo, Guido Roberto, Del Giacco, Luca, Muzi-Falconi, Marco

“…Primary cilia are commonly found on most quiescent, terminally differentiated cells and play a major role in the regulation of the cell cycle, cell motility,…”
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Exploring the pH Sensitivity of Poly(allylamine) Phosphate Supramolecular Nanocarriers for Intracellular siRNA Delivery by Andreozzi, Patrizia, Diamanti, Eleftheria, Py-Daniel, Karen Rapp, Cáceres-Vélez, Paolin Rocio, Martinelli, Chiara, Politakos, Nikolaos, Escobar, Ane, Muzi-Falconi, Marco, Azevedo, Ricardo, Moya, Sergio E

“…Silencing RNA (siRNA) technologies emerge as a promising therapeutic tool for the treatment of multiple diseases. An ideal nanocarrier (NC) for siRNAs should…”
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Spotlight on G-Quadruplexes: From Structure and Modulation to Physiological and Pathological Roles by Dell'Oca, Maria Chiara, Quadri, Roberto, Bernini, Giulia Maria, Menin, Luca, Grasso, Lavinia, Rondelli, Diego, Yazici, Ozge, Sertic, Sarah, Marini, Federica, Pellicioli, Achille, Muzi-Falconi, Marco, Lazzaro, Federico

“…G-quadruplexes or G4s are non-canonical secondary structures of nucleic acids characterized by guanines arranged in stacked tetraplex arrays. Decades of…”
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RNase H and Postreplication Repair Protect Cells from Ribonucleotides Incorporated in DNA by Lazzaro, Federico, Novarina, Daniele, Amara, Flavio, Watt, Danielle L., Stone, Jana E., Costanzo, Vincenzo, Burgers, Peter M., Kunkel, Thomas A., Plevani, Paolo, Muzi-Falconi, Marco

“…The chemical identity and integrity of the genome is challenged by the incorporation of ribonucleoside triphosphates (rNTPs) in place of deoxyribonucleoside…”
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The DNA Damage Checkpoint Response Requires Histone H2B Ubiquitination by Rad6-Bre1 and H3 Methylation by Dot1 by Giannattasio, Michele, Lazzaro, Federico, Plevani, Paolo, Muzi-Falconi, Marco

“…The cellular response to DNA lesions entails the recruitment of several checkpoint and repair factors to damaged DNA, and chromatin modifications may play a…”
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Human exonuclease 1 connects nucleotide excision repair (NER) processing with checkpoint activation in response to UV irradiation by Sertic, Sarah, Pizzi, Sara, Cloney, Ross, Lehmann, Alan R, Marini, Federica, Plevani, Paolo, Muzi-Falconi, Marco

“…UV light induces DNA lesions, which are removed by nucleotide excision repair (NER). Exonuclease 1 (EXO1) is highly conserved from yeast to human and is…”
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gRASping Depolarization: Contribution of RAS GTPases to Mitotic Polarity Clusters Resolution by Quadri, Roberto, Sertic, Sarah, Muzi-Falconi, Marco

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Sensing of replication stress and Mec1 activation act through two independent pathways involving the 9-1-1 complex and DNA polymerase ε by Puddu, Fabio, Piergiovanni, Gabriele, Plevani, Paolo, Muzi-Falconi, Marco

“…Following DNA damage or replication stress, budding yeast cells activate the Rad53 checkpoint kinase, promoting genome stability in these challenging…”
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Phosphorylation of the Budding Yeast 9-1-1 Complex Is Required for Dpb11 Function in the Full Activation of the UV-Induced DNA Damage Checkpoint by Puddu, Fabio, Granata, Magda, Di Nola, Lisa, Balestrini, Alessia, Piergiovanni, Gabriele, Lazzaro, Federico, Giannattasio, Michele, Plevani, Paolo, Muzi-Falconi, Marco

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Detection of ribonucleotides embedded in DNA by Nanopore sequencing by Grasso, Lavinia, Fonzino, Adriano, Manzari, Caterina, Leonardi, Tommaso, Picardi, Ernesto, Gissi, Carmela, Lazzaro, Federico, Pesole, Graziano, Muzi-Falconi, Marco

“…Ribonucleotides represent the most common non-canonical nucleotides found in eukaryotic genomes. The sources of chromosome-embedded ribonucleotides and the…”
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The DNA replication checkpoint response stabilizes stalled replication forks by Foiani, Marco, Lopes, Massimo, Cotta-Ramusino, Cecilia, Pellicioli, Achille, Liberi, Giordano, Plevani, Paolo, Muzi-Falconi, Marco, Newlon, Carol S

“…In response to DNA damage and blocks to replication, eukaryotes activate the checkpoint pathways that prevent genomic instability and cancer by coordinating…”
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14-3-3 Proteins regulate exonuclease 1-dependent processing of stalled replication forks by Engels, Kim, Giannattasio, Michele, Muzi-Falconi, Marco, Lopes, Massimo, Ferrari, Stefano

“…Replication fork integrity, which is essential for the maintenance of genome stability, is monitored by checkpoint-mediated phosphorylation events. 14-3-3…”
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A Haspin-ARHGAP11A axis regulates epithelial morphogenesis through Rho-ROCK dependent modulation of LIMK1-Cofilin by Quadri, Roberto, Rotondo, Giuseppe, Sertic, Sarah, Pozzi, Sara, dell’Oca, Maria Chiara, Guerrini, Luisa, Muzi-Falconi, Marco

“…Throughout mitosis, a plethora of processes must be efficiently concerted to ensure cell proliferation and tissue functionality. The mitotic spindle does not…”
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